Pcmt1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pcmt1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase 1) Rattus norvegicus
Analyze
Symbol: Pcmt1
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
RGD ID: 3268
Description: Enables S-methyltransferase activity and protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Involved in several processes, including S-adenosylmethionine catabolic process; cellular response to hypoxia; and negative regulation of cardiac muscle cell apoptotic process. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and perikaryon. Biomarker of high grade glioma. Orthologous to human PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase); PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: L-isoaspartyl protein carboxyl methyltransferase; MGC95039; PCM; PIMT; protein L-isoaspartyl/D-aspartyl methyltransferase; protein-beta-aspartate methyltransferase; Protein-L-isoaspartate (D-aspartate) O-methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813,932,161 - 3,980,751 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl13,932,161 - 3,964,848 (-)EnsemblGRCr8
mRatBN7.212,111,756 - 2,160,354 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12,111,763 - 2,159,201 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx11,761,587 - 1,794,261 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.017,761,985 - 7,794,661 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012,043,688 - 2,076,362 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd13,401,070 - 3,433,938 (-)NCBI
Lyon_Normotensive12,718,554 - 2,751,422 (-)NCBI
Lyon_Hypertensive13,884,687 - 3,917,555 (-)NCBI
F344_StmMcwi12,272,346 - 2,305,206 (-)NCBI
Rnor_6.011,734,863 - 1,767,759 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl11,736,276 - 1,767,618 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.013,432,543 - 3,464,945 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.412,287,981 - 2,304,638 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1659,884 - 692,976 (-)NCBICelera
RGSC_v3.112,287,981 - 2,304,638 (-)NCBI
Cytogenetic Map1p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
chloropicrin  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
fructose  (EXP)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
LDN-193189  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
N-acetyl-L-cysteine  (ISO)
nefazodone  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tamibarotene  (ISO)
tetrachloromethane  (EXP)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Immunochemical characterization of L-isoaspartyl-protein carboxyl methyltransferase from mammalian tissues. Boivin D, etal., Biochem J. 1995 Aug 1;309 ( Pt 3):993-8.
2. Asparaginyl deamidation-methylation of rat ventricular myosin light chains. Cassidy EM, etal., J Mol Cell Cardiol. 1991 May;23(5):589-601.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: effects on protein-L-isoaspartyl methyltransferase activity. Kharbanda KK, etal., J Hepatol. 2007 Jun;46(6):1119-25. Epub 2007 Feb 16.
6. Embryonic genes expressed in Alzheimer's disease brains. Kondo T, etal., Neurosci Lett. 1996 May 17;209(3):157-60.
7. Expression and activity of l-isoaspartyl methyltransferase decrease in stage progression of human astrocytic tumors. Lapointe M, etal., Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):93-103.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Tissue-specific expression of isoaspartyl protein carboxyl methyltransferase gene in rat brain and testis. Mizobuchi M, etal., J Neurochem 1994 Jan;62(1):322-8.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Primary structure of rat brain protein carboxyl methyltransferase deduced from cDNA sequence. Sato M, etal., Biochem Biophys Res Commun 1989 May 30;161(1):342-7.
14. Protein L-isoaspartyl methyltransferase: developmentally regulated gene expression and protein localization in the central nervous system of aged rat. Shirasawa T, etal., Neurosci Lett. 1995 Mar 16;188(1):37-40.
15. Detection and characterization of a protein isoaspartyl methyltransferase which becomes trapped in the extracellular space during blood vessel injury. Weber DJ and McFadden PN, J Protein Chem. 1997 May;16(4):257-67.
16. Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1. Yan G, etal., Int J Cardiol. 2013 Oct 9;168(4):3291-9. doi: 10.1016/j.ijcard.2013.04.045. Epub 2013 May 3.
Additional References at PubMed
PMID:12023972   PMID:12477932   PMID:12943661   PMID:15489334   PMID:16959769   PMID:23376485   PMID:23533145   PMID:24358311   PMID:24769233   PMID:25468996   PMID:26973341  


Genomics

Comparative Map Data
Pcmt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813,932,161 - 3,980,751 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl13,932,161 - 3,964,848 (-)EnsemblGRCr8
mRatBN7.212,111,756 - 2,160,354 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12,111,763 - 2,159,201 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx11,761,587 - 1,794,261 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.017,761,985 - 7,794,661 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012,043,688 - 2,076,362 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd13,401,070 - 3,433,938 (-)NCBI
Lyon_Normotensive12,718,554 - 2,751,422 (-)NCBI
Lyon_Hypertensive13,884,687 - 3,917,555 (-)NCBI
F344_StmMcwi12,272,346 - 2,305,206 (-)NCBI
Rnor_6.011,734,863 - 1,767,759 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl11,736,276 - 1,767,618 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.013,432,543 - 3,464,945 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.412,287,981 - 2,304,638 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1659,884 - 692,976 (-)NCBICelera
RGSC_v3.112,287,981 - 2,304,638 (-)NCBI
Cytogenetic Map1p13NCBI
PCMT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386149,749,695 - 149,811,421 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6149,749,197 - 149,811,422 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh376150,070,831 - 150,132,557 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366150,112,658 - 150,174,249 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346150,163,078 - 150,224,670NCBI
Celera6150,806,092 - 150,867,242 (+)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6147,636,598 - 147,698,401 (+)NCBIHuRef
CHM1_16150,335,452 - 150,397,161 (+)NCBICHM1_1
T2T-CHM13v2.06150,949,463 - 151,010,794 (+)NCBIT2T-CHM13v2.0
Pcmt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,503,608 - 7,556,922 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl107,503,611 - 7,556,900 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38107,627,845 - 7,681,337 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,629,373 - 7,681,136 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37107,350,034 - 7,383,382 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36107,320,426 - 7,353,440 (-)NCBIMGSCv36mm8
Celera107,508,777 - 7,541,151 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.26NCBI
Pcmt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543911,480,101 - 11,531,839 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495543911,480,094 - 11,531,842 (-)NCBIChiLan1.0ChiLan1.0
PCMT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25169,770,737 - 169,829,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16167,664,782 - 167,723,466 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06147,564,783 - 147,623,402 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16152,271,206 - 152,329,221 (+)NCBIPanPan1.1PanPan1.1panPan2
PCMT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1140,494,441 - 40,539,453 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl140,494,461 - 40,538,937 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha141,333,804 - 41,378,660 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0140,676,439 - 40,721,295 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl140,676,146 - 40,722,403 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1140,552,247 - 40,597,034 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0140,418,203 - 40,463,029 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0140,758,673 - 40,803,514 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pcmt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1816,421,158 - 16,460,475 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024404946135,425,633 - 135,470,265 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364892,677,484 - 2,722,263 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364892,677,740 - 2,720,387 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCMT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,198,223 - 16,249,531 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1116,202,859 - 16,249,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2118,440,912 - 18,462,186 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCMT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11378,801,216 - 78,860,869 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_023666040197,839,664 - 197,899,385 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11321,808,583 - 21,867,309 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1321,807,710 - 21,866,768 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Pcmt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247858,267,328 - 8,326,550 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247858,263,113 - 8,326,549 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl173,746,306 - 73,803,968 (-)Ensembl
Pcmt1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12229,364,327 - 229,412,691 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Pcmt1
479 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:120
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000019623
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat

Markers in Region
RH130061  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.212,111,812 - 2,112,007 (+)MAPPERmRatBN7.2
Rnor_6.011,734,913 - 1,735,107NCBIRnor6.0
Rnor_5.013,432,593 - 3,432,787UniSTSRnor5.0
RGSC_v3.412,288,031 - 2,288,225UniSTSRGSC3.4
Celera1659,934 - 660,128UniSTS
RH 3.4 Map51057.3UniSTS
Cytogenetic Map1p13UniSTS
RH130661  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.212,112,576 - 2,112,788 (+)MAPPERmRatBN7.2
Rnor_6.011,735,677 - 1,735,888NCBIRnor6.0
Rnor_5.013,433,357 - 3,433,568UniSTSRnor5.0
RGSC_v3.412,288,795 - 2,289,006UniSTSRGSC3.4
Celera1660,698 - 660,909UniSTS
RH 3.4 Map112.3UniSTS
Cytogenetic Map1p13UniSTS
RH140246  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.011,736,221 - 1,736,421NCBIRnor6.0
Rnor_5.013,433,901 - 3,434,101UniSTSRnor5.0
RGSC_v3.412,289,339 - 2,289,532UniSTSRGSC3.4
Celera1661,242 - 661,435UniSTS
RH 3.4 Map119.3UniSTS
Cytogenetic Map1p13UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
276 156 730 1591 4066 1011 1728 133 874 496 856 156 5397 2598 449 3979 38 1392 741 909 160 158

Sequence


Ensembl Acc Id: ENSRNOT00000019623   ⟹   ENSRNOP00000019623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl13,932,161 - 3,964,848 (-)Ensembl
mRatBN7.2 Ensembl12,111,763 - 2,159,201 (-)Ensembl
Rnor_6.0 Ensembl11,736,276 - 1,767,618 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123595   ⟹   ENSRNOP00000103701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl13,932,161 - 3,964,754 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150113   ⟹   ENSRNOP00000108494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl13,932,161 - 3,964,848 (-)Ensembl
RefSeq Acc Id: NM_001398561   ⟹   NP_001385490
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813,932,161 - 3,964,848 (-)NCBI
mRatBN7.212,111,763 - 2,144,455 (-)NCBI
Dahl_SR_JrHsd13,401,070 - 3,433,938 (-)NCBI
Lyon_Normotensive12,718,554 - 2,751,422 (-)NCBI
Lyon_Hypertensive13,884,687 - 3,917,555 (-)NCBI
F344_StmMcwi12,272,346 - 2,305,206 (-)NCBI
RefSeq Acc Id: NM_001398562   ⟹   NP_001385491
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813,932,161 - 3,964,848 (-)NCBI
mRatBN7.212,111,763 - 2,144,455 (-)NCBI
Dahl_SR_JrHsd13,401,070 - 3,433,938 (-)NCBI
Lyon_Normotensive12,718,554 - 2,751,422 (-)NCBI
Lyon_Hypertensive13,884,687 - 3,917,555 (-)NCBI
F344_StmMcwi12,272,346 - 2,305,206 (-)NCBI
RefSeq Acc Id: NM_013073   ⟹   NP_037205
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813,932,161 - 3,964,848 (-)NCBI
mRatBN7.212,111,763 - 2,144,455 (-)NCBI
Dahl_SR_JrHsd13,401,070 - 3,433,938 (-)NCBI
Lyon_Normotensive12,718,554 - 2,751,422 (-)NCBI
Lyon_Hypertensive13,884,687 - 3,917,555 (-)NCBI
F344_StmMcwi12,272,346 - 2,305,206 (-)NCBI
Rnor_6.011,734,863 - 1,767,759 (-)NCBI
Rnor_5.013,432,543 - 3,464,945 (-)NCBI
RGSC_v3.412,287,981 - 2,304,638 (-)RGD
Celera1659,884 - 692,976 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102037   ⟹   XP_038957965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813,932,161 - 3,964,638 (-)NCBI
mRatBN7.212,111,763 - 2,144,368 (-)NCBI
RefSeq Acc Id: XM_039102058   ⟹   XP_038957986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813,932,161 - 3,980,751 (-)NCBI
mRatBN7.212,111,763 - 2,160,354 (-)NCBI
RefSeq Acc Id: XM_063282051   ⟹   XP_063138121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813,932,161 - 3,964,638 (-)NCBI
RefSeq Acc Id: XM_063282056   ⟹   XP_063138126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813,932,161 - 3,963,826 (-)NCBI
RefSeq Acc Id: XM_063282061   ⟹   XP_063138131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813,932,161 - 3,947,645 (-)NCBI
RefSeq Acc Id: NP_037205   ⟸   NM_013073
- Peptide Label: isoform b
- UniProtKB: A0A140TAB9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019623   ⟸   ENSRNOT00000019623
RefSeq Acc Id: XP_038957986   ⟸   XM_039102058
- Peptide Label: isoform X3
- UniProtKB: Q5M7V6 (UniProtKB/Swiss-Prot),   P22062 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957965   ⟸   XM_039102037
- Peptide Label: isoform X1
- UniProtKB: A0ABK0LDS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385491   ⟸   NM_001398562
- Peptide Label: isoform c
- UniProtKB: A0ABK0LTJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385490   ⟸   NM_001398561
- Peptide Label: isoform a
RefSeq Acc Id: XP_063138121   ⟸   XM_063282051
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063138126   ⟸   XM_063282056
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063138131   ⟸   XM_063282061
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000108494   ⟸   ENSRNOT00000150113
Ensembl Acc Id: ENSRNOP00000103701   ⟸   ENSRNOT00000123595

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22062-F1-model_v2 AlphaFold P22062 1-227 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3268 AgrOrtholog
BioCyc Gene G2FUF-62453 BioCyc
Ensembl Genes ENSRNOG00000014330 Ensembl, ENTREZGENE
  ENSRNOG00055009651 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019623 ENTREZGENE
  ENSRNOT00000123595 ENTREZGENE
  ENSRNOT00000150113 ENTREZGENE
  ENSRNOT00055016341 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7123213 IMAGE-MGC_LOAD
InterPro PCMT UniProtKB/Swiss-Prot
  SAM-dependent_MTases UniProtKB/Swiss-Prot
KEGG Report rno:25604 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95039 IMAGE-MGC_LOAD
NCBI Gene 25604 ENTREZGENE
PANTHER PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE UniProtKB/Swiss-Prot
  PTHR11579 UniProtKB/Swiss-Prot
Pfam PCMT UniProtKB/Swiss-Prot
PhenoGen Pcmt1 PhenoGen
PROSITE PCMT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014330 RatGTEx
  ENSRNOG00055009651 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot
UniProt A0A140TAB9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LDS9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LTJ2 ENTREZGENE, UniProtKB/TrEMBL
  P22062 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5M7V6 ENTREZGENE
UniProt Secondary Q5M7V6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pcmt1  Protein-L-isoaspartate (D-aspartate) O-methyltransferase      Symbol and Name status set to approved 70586 APPROVED