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small cell lung carcinoma pathway - Ontology Report - Rat Genome Database

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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:small cell lung carcinoma pathway
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Accession:PW:0000704 term browser browse the term
Definition:Small cell lung cancer is an aggressive type of lung cancer. Several pathways appear to be deregulated and they include the intrinsic apoptotic pathway, PI3K-Akt signaling and changes in oncogene transcription factors such as Myc and p53.
Synonyms:exact_synonym: oat cell carcinoma of lung pathway;   small cell carcinoma of lung pathway;   small cell lung cancer pathway;   small cell neuroendocrine carcinoma of lung pathway
 related_synonym: KEGG:05222;   SCLC pathway;   small cell lung neoplasm pathway

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small cell lung carcinoma pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 IEA KEGG hsa:05222 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 IEA KEGG hsa:05222 NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536 		JBrowse link
G AKT3 AKT serine/threonine kinase 3 IEA KEGG hsa:05222 NCBI chr 1:243,488,233...243,851,079
Ensembl chr 1:243,488,233...243,851,079 		JBrowse link
G APAF1 apoptotic peptidase activating factor 1 IEA KEGG hsa:05222 NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433 		JBrowse link
G BCL2 BCL2 apoptosis regulator IEA KEGG hsa:05222 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 IEA KEGG hsa:05222 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 IEA KEGG hsa:05222 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 IEA KEGG hsa:05222 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G CASP9 caspase 9 IEA KEGG hsa:05222 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CCND1 cyclin D1 IEA KEGG hsa:05222 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNE1 cyclin E1 IEA KEGG hsa:05222 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CCNE2 cyclin E2 IEA KEGG hsa:05222 NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678 		JBrowse link
G CDK2 cyclin dependent kinase 2 IEA KEGG hsa:05222 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDK4 cyclin dependent kinase 4 IEA KEGG hsa:05222 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013 		JBrowse link
G CDK6 cyclin dependent kinase 6 IEA KEGG hsa:05222 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B IEA KEGG hsa:05222 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B IEA KEGG hsa:05222 NCBI chr 9:22,002,903...22,009,313
Ensembl chr 9:22,002,903...22,009,305 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex IEA KEGG hsa:05222 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G CKS1B CDC28 protein kinase regulatory subunit 1B IEA KEGG hsa:05222 NCBI chr 1:154,974,681...154,979,251
Ensembl chr 1:154,974,653...154,979,251 		JBrowse link
G COL4A1 collagen type IV alpha 1 chain IEA KEGG hsa:05222 NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,202 		JBrowse link
G COL4A2 collagen type IV alpha 2 chain IEA KEGG hsa:05222 NCBI chr13:110,307,284...110,513,209
Ensembl chr13:110,305,812...110,513,209 		JBrowse link
G COL4A4 collagen type IV alpha 4 chain IEA KEGG hsa:05222 NCBI chr 2:226,967,360...227,164,488
Ensembl chr 2:227,002,714...227,164,453 		JBrowse link
G COL4A5 collagen type IV alpha 5 chain IEA KEGG hsa:05222 NCBI chr  X:108,439,838...108,697,545
Ensembl chr  X:108,439,838...108,697,545 		JBrowse link
G COL4A6 collagen type IV alpha 6 chain IEA KEGG hsa:05222 NCBI chr  X:108,155,614...108,439,458
Ensembl chr  X:108,155,607...108,439,497 		JBrowse link
G CYCS cytochrome c, somatic IEA KEGG hsa:05222 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G E2F1 E2F transcription factor 1 IEA KEGG hsa:05222 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385 		JBrowse link
G E2F2 E2F transcription factor 2 IEA KEGG hsa:05222 NCBI chr 1:23,505,212...23,531,233
Ensembl chr 1:23,506,438...23,531,233 		JBrowse link
G E2F3 E2F transcription factor 3 IEA KEGG hsa:05222 NCBI chr 6:20,401,879...20,493,714
Ensembl chr 6:20,401,879...20,493,714 		JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase IEA KEGG hsa:05222 NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459 		JBrowse link
G FN1 fibronectin 1 IEA KEGG hsa:05222 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG hsa:05222 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma IEA KEGG hsa:05222 NCBI chr  X:154,541,238...154,565,046
Ensembl chr  X:154,541,199...154,565,046 		JBrowse link
G ITGA2 integrin subunit alpha 2 IEA KEGG hsa:05222 NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779 		JBrowse link
G ITGA2B integrin subunit alpha 2b IEA KEGG hsa:05222 NCBI chr17:44,372,181...44,389,649
Ensembl chr17:44,372,180...44,389,649 		JBrowse link
G ITGA3 integrin subunit alpha 3 IEA KEGG hsa:05222 NCBI chr17:50,056,110...50,090,481
Ensembl chr17:50,055,968...50,090,481 		JBrowse link
G ITGA6 integrin subunit alpha 6 IEA KEGG hsa:05222 NCBI chr 2:172,427,336...172,506,459
Ensembl chr 2:172,234,216...172,506,459 		JBrowse link
G ITGAV integrin subunit alpha V IEA KEGG hsa:05222 NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,010...186,680,901 		JBrowse link
G ITGB1 integrin subunit beta 1 IEA KEGG hsa:05222 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792 		JBrowse link
G LAMA1 laminin subunit alpha 1 IEA KEGG hsa:05222 NCBI chr18:6,941,742...7,117,797
Ensembl chr18:6,941,742...7,117,797 		JBrowse link
G LAMA2 laminin subunit alpha 2 IEA KEGG hsa:05222 NCBI chr 6:128,883,138...129,516,566
Ensembl chr 6:128,883,138...129,516,566 		JBrowse link
G LAMA3 laminin subunit alpha 3 IEA KEGG hsa:05222 NCBI chr18:23,689,453...23,955,066
Ensembl chr18:23,689,453...23,956,222 		JBrowse link
G LAMA4 laminin subunit alpha 4 IEA KEGG hsa:05222 NCBI chr 6:112,107,931...112,254,985
Ensembl chr 6:112,107,931...112,254,939 		JBrowse link
G LAMA5 laminin subunit alpha 5 IEA KEGG hsa:05222 NCBI chr20:62,309,065...62,367,312
Ensembl chr20:62,307,955...62,367,312 		JBrowse link
G LAMB1 laminin subunit beta 1 IEA KEGG hsa:05222 NCBI chr 7:107,923,799...108,003,161
Ensembl chr 7:107,923,799...108,003,213 		JBrowse link
G LAMB2 laminin subunit beta 2 IEA KEGG hsa:05222 NCBI chr 3:49,121,114...49,133,050
Ensembl chr 3:49,121,114...49,133,118 		JBrowse link
G LAMB3 laminin subunit beta 3 IEA KEGG hsa:05222 NCBI chr 1:209,614,870...209,652,425
Ensembl chr 1:209,614,870...209,652,425 		JBrowse link
G LAMB4 laminin subunit beta 4 IEA KEGG hsa:05222 NCBI chr 7:108,011,662...108,130,361
Ensembl chr 7:108,023,548...108,130,361 		JBrowse link
G LAMC1 laminin subunit gamma 1 IEA KEGG hsa:05222 NCBI chr 1:183,023,420...183,145,592
Ensembl chr 1:183,023,420...183,145,592 		JBrowse link
G LAMC2 laminin subunit gamma 2 IEA KEGG hsa:05222 NCBI chr 1:183,186,264...183,258,968
Ensembl chr 1:183,186,238...183,245,127 		JBrowse link
G LAMC3 laminin subunit gamma 3 IEA KEGG hsa:05222 NCBI chr 9:131,009,174...131,094,473
Ensembl chr 9:131,009,174...131,094,473 		JBrowse link
G MAX MYC associated factor X IEA KEGG hsa:05222 NCBI chr14:65,006,101...65,102,695
Ensembl chr14:65,006,174...65,102,695 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor IEA KEGG hsa:05222 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 IEA KEGG hsa:05222 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha IEA KEGG hsa:05222 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 IEA KEGG hsa:05222 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PIAS1 protein inhibitor of activated STAT 1 IEA KEGG hsa:05222 NCBI chr15:68,054,315...68,193,847
Ensembl chr15:68,054,309...68,198,603 		JBrowse link
G PIAS2 protein inhibitor of activated STAT 2 IEA KEGG hsa:05222 NCBI chr18:46,803,218...46,920,145
Ensembl chr18:46,803,218...46,920,160 		JBrowse link
G PIAS3 protein inhibitor of activated STAT 3 IEA KEGG hsa:05222 NCBI chr 1:145,848,522...145,859,081
Ensembl chr 1:145,848,522...145,859,836 		JBrowse link
G PIAS4 protein inhibitor of activated STAT 4 IEA KEGG hsa:05222 NCBI chr19:4,007,736...4,039,386
Ensembl chr19:4,007,736...4,039,386 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IEA KEGG hsa:05222 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093 		JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta IEA KEGG hsa:05222 NCBI chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,336...138,834,928 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IEA KEGG hsa:05222 NCBI chr 1:9,627,258...9,729,114
Ensembl chr 1:9,629,889...9,729,114 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IEA KEGG hsa:05222 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG hsa:05222 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821 		JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG hsa:05222 NCBI chr19:18,153,163...18,170,532
Ensembl chr19:18,153,163...18,170,540 		JBrowse link
G PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG hsa:05222 NCBI chr 1:46,040,140...46,174,901
Ensembl chr 1:46,040,140...46,133,036 		JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 IEA KEGG hsa:05222 NCBI chr17:8,878,916...8,965,707
Ensembl chr17:8,878,911...8,965,712 		JBrowse link
G PTEN phosphatase and tensin homolog IEA KEGG hsa:05222 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 IEA KEGG hsa:05222 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTK2 protein tyrosine kinase 2 IEA KEGG hsa:05222 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216 		JBrowse link
G RARB retinoic acid receptor beta IEA KEGG hsa:05222 NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:24,687,887...25,597,932 		JBrowse link
G RB1 RB transcriptional corepressor 1 IEA KEGG hsa:05222 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit IEA KEGG hsa:05222 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RXRA retinoid X receptor alpha IEA KEGG hsa:05222 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585 		JBrowse link
G RXRB retinoid X receptor beta IEA KEGG hsa:05222 NCBI chr 6:33,193,588...33,200,853
Ensembl chr 6:33,193,588...33,200,665 		JBrowse link
G RXRG retinoid X receptor gamma IEA KEGG hsa:05222 NCBI chr 1:165,400,922...165,445,126
Ensembl chr 1:165,400,922...165,445,355 		JBrowse link
G SKP2 S-phase kinase associated protein 2 IEA KEGG hsa:05222 NCBI chr 5:36,152,111...36,193,530
Ensembl chr 5:36,151,989...36,196,849 		JBrowse link
G TP53 tumor protein p53 IEA KEGG hsa:05222 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TRAF1 TNF receptor associated factor 1 IEA KEGG hsa:05222 NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173 		JBrowse link
G TRAF2 TNF receptor associated factor 2 IEA KEGG hsa:05222 NCBI chr 9:136,881,958...136,926,607
Ensembl chr 9:136,881,912...136,926,607 		JBrowse link
G TRAF3 TNF receptor associated factor 3 IEA KEGG hsa:05222 NCBI chr14:102,777,449...102,911,500
Ensembl chr14:102,777,449...102,911,500 		JBrowse link
G TRAF4 TNF receptor associated factor 4 IEA KEGG hsa:05222 NCBI chr17:28,744,011...28,750,956
Ensembl chr17:28,744,011...28,750,956 		JBrowse link
G TRAF5 TNF receptor associated factor 5 IEA KEGG hsa:05222 NCBI chr 1:211,326,635...211,374,946
Ensembl chr 1:211,326,615...211,374,946 		JBrowse link
G TRAF6 TNF receptor associated factor 6 IEA KEGG hsa:05222 NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272 		JBrowse link
G XIAP X-linked inhibitor of apoptosis IEA KEGG hsa:05222 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
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  pathway 5957
    disease pathway 2076
      cancer pathway 389
        thoracic cancer pathway 115
          respiratory tract cancer pathway 115
            lung cancer pathway 115
              small cell lung carcinoma pathway 85
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