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ONTOLOGY REPORT - ANNOTATIONS

Term:glycosaminoglycan biosynthetic process
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Accession:GO:0006024 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.
Synonyms:exact_synonym: glycosaminoglycan anabolism;   glycosaminoglycan biosynthesis;   glycosaminoglycan formation;   glycosaminoglycan synthesis

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glycosaminoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3galt6 Beta-1,3-galactosyltransferase 6 involved_in ISO
IBA		 (PMID:11551958)
PMID:21873635
(MGI:2152770|PMID:11551958)		 RGD PMID:11551958, PMID:21873635 MGI:2152770, RGD:13792537 NCBI chr 5:173,423,475...173,425,611
Ensembl chr 5:173,423,475...173,425,611 		JBrowse link
G B3gat3 beta-1,3-glucuronyltransferase 3 involved_in ISO (PMID:24425863), (PMID:25893793) RGD PMID:24425863 PMID:25893793 NCBI chr 1:225,120,061...225,126,579
Ensembl chr 1:225,120,061...225,126,579 		JBrowse link
G B4galt7 beta-1,4-galactosyltransferase 7 involved_in ISO
ISS		 (PMID:10438455)
GO_REF:0000024		 RGD
UniProt		 PMID:10438455 GO_REF:0000024 NCBI chr17:9,549,605...9,558,672
Ensembl chr17:9,550,028...9,558,634 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 involved_in ISO (PMID:12907669) RGD PMID:12907669 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068 		JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in ISO (PMID:12907669) RGD PMID:12907669 NCBI chr 3:82,602,784...82,734,557
Ensembl chr 3:82,602,785...82,734,533 		JBrowse link
G Hexa hexosaminidase subunit alpha involved_in ISO (PMID:25645918) RGD PMID:25645918 NCBI chr 8:64,325,435...64,350,775
Ensembl chr 8:64,325,435...64,350,773 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IMP RGD PMID:11903042 RGD:1581762 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381 		JBrowse link
G Pxylp1 2-phosphoxylose phosphatase 1 involved_in ISO
IBA
ISS		 (PMID:24425863)
PMID:21873635
GO_REF:0000024		 RGD
UniProt		 PMID:24425863, PMID:21873635, PMID:21873635 GO_REF:0000024, RGD:13792537, RGD:13792537 NCBI chr 8:104,724,728...104,790,639
Ensembl chr 8:104,724,743...104,790,639 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845 		JBrowse link
G Xylt1 xylosyltransferase 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:186,939,698...187,264,758
Ensembl chr 1:187,149,453...187,261,632 		JBrowse link
G Xylt2 xylosyltransferase 2 ISO MGI:3714171 (MGI:3713963|PMID:17517600) RGD PMID:17517600 MGI:3713963 NCBI chr10:82,386,003...82,399,485
Ensembl chr10:82,386,005...82,399,485 		JBrowse link
chondroitin sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07032202.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 Ensembl chr18:54,206,651...54,207,523 JBrowse link
G Chpf chondroitin polymerizing factor involved_in ISO
IBA		 (PMID:12761225)
PMID:21873635
MGI:2681120|MGI:5464019 (MGI:5462280|PMID:22952873), (MGI:5462286|PMID:22952769)		 RGD PMID:12761225 PMID:22952769 PMID:22952873, PMID:21873635, PMID:21873635 MGI:5462280 MGI:5462286, RGD:13792537, RGD:13792537 NCBI chr 9:82,669,199...82,673,898
Ensembl chr 9:82,669,204...82,673,898 		JBrowse link
G Chpf2 chondroitin polymerizing factor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 4:7,108,461...7,113,940
Ensembl chr 4:7,108,462...7,113,919 		JBrowse link
G Chst11 carbohydrate sulfotransferase 11 involved_in ISO (PMID:11056388)
MGI:1926002 (MGI:1354846|PMID:10722746), (MGI:4941099|PMID:21138417)		 RGD PMID:10722746 PMID:11056388 PMID:21138417 MGI:1354846 MGI:4941099 NCBI chr 7:26,641,856...26,890,503
Ensembl chr 7:26,645,422...26,859,716 		JBrowse link
G Chst12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) RGD PMID:10781601 NCBI chr12:16,199,975...16,218,404
Ensembl chr12:16,200,019...16,201,632 		JBrowse link
G Chst13 carbohydrate sulfotransferase 13 involved_in ISO (PMID:12080076) RGD PMID:12080076 NCBI chr 4:122,223,846...122,244,848
Ensembl chr 4:122,224,535...122,237,754 		JBrowse link
G Chst3 carbohydrate sulfotransferase 3 involved_in IEA
ISO
IBA		 GO_REF:0000107
(PMID:9883891)
PMID:21873635
MGI:2176247 (MGI:1206144|PMID:9597547), (MGI:2156294|PMID:11696535)		 Ensembl
RGD		 PMID:9597547 PMID:9883891 PMID:11696535, PMID:21873635, PMID:21873635 GO_REF:0000107 MGI:1206144 MGI:2156294, RGD:13792537, RGD:13792537 NCBI chr20:29,731,828...29,768,656
Ensembl chr20:29,731,816...29,738,506 		JBrowse link
G Chst7 carbohydrate sulfotransferase 7 involved_in ISO
IBA		 (PMID:10781596)
PMID:21873635		 RGD PMID:10781596, PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr  X:2,623,018...2,657,155
Ensembl chr  X:2,623,024...2,657,155 		JBrowse link
G Chsy1 chondroitin sulfate synthase 1 involved_in ISO
IBA		 (PMID:11514575)
PMID:21873635
MGI:106576 (MGI:5462286|PMID:22952769)		 RGD PMID:11514575 PMID:22952769, PMID:21873635 MGI:5462286, RGD:13792537 NCBI chr 1:127,010,587...127,071,570
Ensembl chr 1:127,010,588...127,071,570 		JBrowse link
G Chsy3 chondroitin sulfate synthase 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr18:54,243,626...54,497,475
Ensembl chr18:54,243,949...54,496,585 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in ISO
IBA		 (PMID:11514575), (PMID:12163485)
PMID:21873635		 RGD PMID:11514575 PMID:12163485, PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr16:22,704,318...23,075,071
Ensembl chr16:22,979,444...23,074,798 		JBrowse link
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 4:150,148,626...150,185,062
Ensembl chr 4:150,153,844...150,185,044 		JBrowse link
G Slc35d1 solute carrier family 35 member D1 ISO MGI:3774133 (MGI:3771453|PMID:17952091) RGD PMID:17952091 MGI:3771453 NCBI chr 5:122,700,396...122,746,815
Ensembl chr 5:122,699,587...122,746,839 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:2675908|PMID:14505572)		 UniProt
Ensembl
RGD		 PMID:14505572 GO_REF:0000024 GO_REF:0000107 MGI:2675908 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845 		JBrowse link
G Xylt1 xylosyltransferase 1 involved_in IEA
ISO		 GO_REF:0000041
(MGI:5544658|PMID:24161523)		 UniProt
RGD		 PMID:24161523 GO_REF:0000041 MGI:5544658 NCBI chr 1:186,939,698...187,264,758
Ensembl chr 1:187,149,453...187,261,632 		JBrowse link
G Xylt2 xylosyltransferase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr10:82,386,003...82,399,485
Ensembl chr10:82,386,005...82,399,485 		JBrowse link
dermatan sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chst12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) RGD PMID:10781601 NCBI chr12:16,199,975...16,218,404
Ensembl chr12:16,200,019...16,201,632 		JBrowse link
G Chst14 carbohydrate sulfotransferase 14 involved_in ISO (PMID:11470797) RGD PMID:11470797 NCBI chr 3:110,734,105...110,736,162
Ensembl chr 3:110,734,105...110,736,162 		JBrowse link
G Dse dermatan sulfate epimerase involved_in ISO (PMID:16505484) RGD PMID:16505484 NCBI chr20:27,703,738...27,784,982
Ensembl chr20:27,703,732...27,782,586 		JBrowse link
heparin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:19297368)		 Ensembl
RGD		 PMID:19297368 GO_REF:0000107 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 ISO MGI:108050 (MGI:1888607|PMID:10926768), (MGI:3050709|PMID:15161920), (MGI:3051956|PMID:15177029), (MGI:4360160|PMID:18480751), (MGI:6406739|PMID:21310272), (MGI:6406770|PMID:21148566) RGD PMID:10926768 PMID:15161920 PMID:15177029 PMID:18480751 PMID:21148566 PMID:21310272 MGI:1888607 MGI:3050709 MGI:3051956 MGI:4360160 MGI:6406739 MGI:6406770 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068 		JBrowse link
G Ext2 exostosin glycosyltransferase 2 ISO MGI:894663 (MGI:6406739|PMID:21310272) RGD PMID:21310272 MGI:6406739 NCBI chr 3:82,602,784...82,734,557
Ensembl chr 3:82,602,785...82,734,533 		JBrowse link
G Glce glucuronic acid epimerase involved_in IEA
ISO		 GO_REF:0000041
(MGI:2135754|PMID:11279150)		 UniProt
RGD		 PMID:11279150 GO_REF:0000041 MGI:2135754 NCBI chr 8:67,006,588...67,073,723
Ensembl chr 8:67,006,592...67,040,005 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr18:55,951,497...56,014,107
Ensembl chr18:55,955,389...55,992,885 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr15:3,995,797...4,006,491
Ensembl chr15:3,996,048...4,006,491 		JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:227,736,491...227,903,657
Ensembl chr 2:227,738,650...227,890,077 		JBrowse link
G Ndst4 N-deacetylase and N-sulfotransferase 4 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:229,170,781...229,496,732
Ensembl chr 2:229,196,616...229,496,516 		JBrowse link
G NEWGENE_1304700 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr15:3,750,058...3,760,616
Ensembl chr15:3,754,262...3,760,663 		JBrowse link
G Slc10a7 solute carrier family 10, member 7 involved_in ISO (PMID:30082715)
(MGI:6198941|PMID:30082715)		 RGD PMID:30082715 MGI:6198941 NCBI chr19:32,857,984...33,081,359
Ensembl chr19:32,855,343...33,080,998 		JBrowse link
G Xylt2 xylosyltransferase 2 involved_in IEA
ISO		 GO_REF:0000107
MGI:3714171 (MGI:3713963|PMID:17517600)		 Ensembl
RGD		 PMID:17517600 GO_REF:0000107 MGI:3713963 NCBI chr10:82,386,003...82,399,485
Ensembl chr10:82,386,005...82,399,485 		JBrowse link
hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd3 cyclin D3 IMP RGD PMID:19276076 RGD:2316018 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943 		JBrowse link
G Has1 hyaluronan synthase 1 involved_in ISO
IBA		 (MGI:1351415|PMID:10617644)
PMID:21873635		 RGD PMID:10617644, PMID:21873635, PMID:21873635 MGI:1351415, RGD:13792537, RGD:13792537 NCBI chr 1:59,720,612...59,732,409
Ensembl chr 1:59,720,612...59,732,409 		JBrowse link
G Has2 hyaluronan synthase 2 involved_in IEA
ISO
IEP
IBA		 GO_REF:0000041
(PMID:17324121), (PMID:22016393)
PMID:19635555
PMID:21873635
(MGI:1861536|PMID:10930438)		 UniProt
RGD		 PMID:10930438 PMID:17324121 PMID:22016393, PMID:19635555, PMID:21873635, PMID:19635555 GO_REF:0000041 MGI:1861536, RGD:8553259, RGD:13792537, RGD:8553259 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049 		JBrowse link
G Has3 hyaluronan synthase 3 involved_in ISO
IBA		 (PMID:16900089)
PMID:21873635
(MGI:86804|PMID:9060470)		 RGD PMID:9060470 PMID:16900089, PMID:21873635, PMID:21873635 MGI:86804, RGD:13792537, RGD:13792537 NCBI chr19:39,063,298...39,077,745
Ensembl chr19:39,063,998...39,077,722 		JBrowse link
G Hyal1 hyaluronidase 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:21829529)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:21829529 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:116,332,834...116,337,522
Ensembl chr 8:116,332,796...116,335,435 		JBrowse link
G Il1b interleukin 1 beta involved_in IEA
ISO		 GO_REF:0000107
(PMID:15100360)		 Ensembl
RGD		 PMID:15100360 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
keratan sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chst5 carbohydrate sulfotransferase 5 involved_in ISO
IBA		 (PMID:11278593)
PMID:21873635
(MGI:1934540|PMID:11278593)		 RGD PMID:11278593, PMID:21873635, PMID:21873635 MGI:1934540, RGD:13792537, RGD:13792537 NCBI chr19:44,115,065...44,136,092
Ensembl chr19:44,115,120...44,135,387 		JBrowse link
negative regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 involved_in ISO (PMID:23509262), (PMID:24251095) RGD PMID:23509262 PMID:24251095 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335 		JBrowse link
G Cltc clathrin heavy chain involved_in ISS
ISO		 GO_REF:0000024
(PMID:23509262), (PMID:24251095)		 UniProt
RGD		 PMID:23509262 PMID:24251095 GO_REF:0000024 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in IEA
ISO		 GO_REF:0000107
MGI:1856877 (MGI:5320806|PMID:22383528)		 Ensembl
RGD		 PMID:22383528 GO_REF:0000107 MGI:5320806 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS		 (PMID:17324121)
GO_REF:0000024		 RGD
UniProt		 PMID:17324121 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
positive regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor involved_in ISO (PMID:17324121) RGD PMID:17324121 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Has2 hyaluronan synthase 2 IDA
IMP		 RGD PMID:12186949, PMID:17080198 RGD:9588629, RGD:9588632 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:17324121)		 Ensembl
RGD		 PMID:17324121 GO_REF:0000107 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:17324121)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:17324121 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:17080198 RGD:9588632 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448 		JBrowse link
regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 ISO MGI:1856877 (MGI:5320806|PMID:22383528) RGD PMID:22383528 MGI:5320806 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    metabolic process 12140
      organic substance metabolic process 11646
        macromolecule metabolic process 10055
          aminoglycan metabolic process 122
            aminoglycan biosynthetic process 62
              glycosaminoglycan biosynthetic process 49
                chondroitin sulfate biosynthetic process 16
                dermatan sulfate biosynthetic process 3
                galactosaminoglycan biosynthetic process 0
                heparin biosynthetic process 11
                hyaluronan biosynthetic process + 14
                keratan sulfate biosynthetic process 1
                peptidoglycan biosynthetic process + 0
paths to the root