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ONTOLOGY REPORT - ANNOTATIONS

Term:glycosaminoglycan biosynthetic process
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Accession:GO:0006024 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.
Synonyms:exact_synonym: glycosaminoglycan anabolism;   glycosaminoglycan biosynthesis;   glycosaminoglycan formation;   glycosaminoglycan synthesis


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glycosaminoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3galt6 Beta-1,3-galactosyltransferase 6 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:11551958)
GO_REF:0000033		 RGD
GO_Central		 PMID:11551958 GO_REF:0000033 NCBI chr 5:171,866,428...171,868,564
Ensembl chr 5:166,584,202...166,586,338 		JBrowse link
G B3gat1 beta-1,3-glucuronyltransferase 1 involved_in ISO
IEA		 MGI:3759445 (PMID:12032138), (PMID:26659409)
GO_REF:0000107		 RGD
Ensembl		 PMID:12032138 PMID:26659409 GO_REF:0000107 NCBI chr 8:25,087,123...25,114,692
Ensembl chr 8:25,087,547...25,113,395 		JBrowse link
G B3gat3 beta-1,3-glucuronyltransferase 3 involved_in ISO (PMID:24425863), (PMID:25893793)
MGI:5697553 (PMID:20164174), (PMID:21771787)		 RGD PMID:20164174 PMID:21771787 PMID:24425863 PMID:25893793 NCBI chr 1:215,246,453...215,253,033
Ensembl chr 1:205,817,378...205,837,807 		JBrowse link
G B4galt7 beta-1,4-galactosyltransferase 7 involved_in ISO
IEA		 (PMID:10438455)
GO_REF:0000107
UniProtKB:Q9UBV7 (PMID:20809901), (PMID:33208938)		 RGD
Ensembl		 PMID:10438455 PMID:20809901 PMID:33208938 GO_REF:0000107 NCBI chr17:9,023,667...9,032,742
Ensembl chr17:9,018,935...9,027,573 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 involved_in ISO
IEA		 (PMID:12907669)
GO_REF:0000107		 RGD
Ensembl		 PMID:12907669 GO_REF:0000107 NCBI chr 7:86,265,651...86,544,488
Ensembl chr 7:84,375,784...84,655,357 		JBrowse link
G Ext2 exostosin glycosyltransferase 2 involved_in ISO
IEA		 (PMID:12907669)
GO_REF:0000107		 RGD
Ensembl		 PMID:12907669 GO_REF:0000107 NCBI chr 3:79,665,414...79,798,077
Ensembl chr 3:79,665,415...79,798,059 		JBrowse link
G Has1 hyaluronan synthase 1 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397 		JBrowse link
G Has2 hyaluronan synthase 2 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Has3 hyaluronan synthase 3 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr19:34,768,421...34,782,170
Ensembl chr19:34,771,982...34,782,592 		JBrowse link
G Hexa hexosaminidase subunit alpha involved_in ISO
IEA		 (PMID:25645918)
GO_REF:0000107		 RGD
Ensembl		 PMID:25645918 GO_REF:0000107 NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013 		JBrowse link
G Hs3st1 heparan sulfate-glucosamine 3-sulfotransferase 1 involved_in ISO
IEA		 (PMID:8900198), (PMID:9988768)
(PMID:15060080)
GO_REF:0000107		 RGD
Ensembl		 PMID:8900198 PMID:9988768 PMID:15060080 GO_REF:0000107 NCBI chr14:75,398,101...75,429,628
Ensembl chr14:71,185,682...71,223,248 		JBrowse link
G Hs3st2 heparan sulfate-glucosamine 3-sulfotransferase 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:9988768)		 UniProt
RGD		 PMID:9988768 GO_REF:0000024 NCBI chr 1:175,956,161...176,077,400
Ensembl chr 1:175,956,157...176,077,399 		JBrowse link
G Hs3st3a1 heparan sulfate-glucosamine 3-sulfotransferase 3A1 involved_in ISO
IEA		 (PMID:15304505), (PMID:9988768)
GO_REF:0000107		 RGD
Ensembl		 PMID:9988768 PMID:15304505 GO_REF:0000107 NCBI chr10:49,593,208...49,679,854
Ensembl chr10:49,094,026...49,180,676 		JBrowse link
G Hs3st3b1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 involved_in ISO
IEA		 (PMID:9988768)
GO_REF:0000107		 RGD
Ensembl		 PMID:9988768 GO_REF:0000107 NCBI chr10:48,561,473...48,593,970
Ensembl chr10:48,561,473...48,593,970 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IMP RGD PMID:11903042 RGD:1581762 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pxylp1 2-phosphoxylose phosphatase 1 involved_in ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(PMID:24425863)		 UniProt
Ensembl
GO_Central
RGD		 PMID:24425863 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:106,299,303...106,364,603
Ensembl chr 8:97,419,776...97,485,064 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:43,202,480...43,226,002
Ensembl chr14:42,848,854...42,872,354 		JBrowse link
G Xylt1 xylosyltransferase 1 involved_in ISO MGI:5563785 (PMID:24161523) RGD PMID:24161523 NCBI chr 1:181,078,222...181,361,047
Ensembl chr 1:171,643,925...171,926,783 		JBrowse link
G Xylt2 xylosyltransferase 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 MGI:3714171 (PMID:17517600)
GO_REF:0000107		 RGD
Ensembl		 PMID:17517600 GO_REF:0000107 NCBI chr10:80,102,776...80,116,346
Ensembl chr10:79,606,007...79,619,391 		JBrowse link
chondroitin sulfate proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3galt6 Beta-1,3-galactosyltransferase 6 involved_in ISO (PMID:23664118) RGD PMID:23664118 NCBI chr 5:171,866,428...171,868,564
Ensembl chr 5:166,584,202...166,586,338 		JBrowse link
G B3gat1 beta-1,3-glucuronyltransferase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:25,087,123...25,114,692
Ensembl chr 8:25,087,547...25,113,395 		JBrowse link
G B3gat2 beta-1,3-glucuronyltransferase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:26,167,174...26,250,153
Ensembl chr 9:26,167,174...26,250,153 		JBrowse link
G B3gat3 beta-1,3-glucuronyltransferase 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:25893793)
(PMID:21763480)		 RGD PMID:21763480 PMID:25893793 NCBI chr 1:215,246,453...215,253,033
Ensembl chr 1:205,817,378...205,837,807 		JBrowse link
G Chpf chondroitin polymerizing factor involved_in IEA
ISO		 GO_REF:0000107
(PMID:12716890), (PMID:12761225)		 Ensembl
RGD		 PMID:12716890 PMID:12761225 GO_REF:0000107 NCBI chr 9:76,963,178...76,967,878
Ensembl chr 9:76,963,184...76,967,878 		JBrowse link
G Chst11 carbohydrate sulfotransferase 11 involved_in ISO (PMID:11056388) RGD PMID:11056388 NCBI chr 7:22,412,121...22,630,577
Ensembl chr 7:20,528,100...20,743,111 		JBrowse link
G Chst12 carbohydrate sulfotransferase 12 involved_in ISO (PMID:10781601) RGD PMID:10781601 NCBI chr12:14,110,631...14,129,099
Ensembl chr12:14,110,393...14,129,057 		JBrowse link
G Chst13 carbohydrate sulfotransferase 13 involved_in IEA
ISO		 GO_REF:0000107
(PMID:12080076)		 Ensembl
RGD		 PMID:12080076 GO_REF:0000107 NCBI chr 4:122,824,022...122,837,940
Ensembl chr 4:122,824,022...122,838,019 		JBrowse link
G Chst3 carbohydrate sulfotransferase 3 involved_in IDA
ISO
IEA
ISS		 (PMID:15215498), (PMID:9883891)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:9883891 PMID:15215498 PMID:16495484 GO_REF:0000024 GO_REF:0000107, RGD:1600854 NCBI chr20:28,114,386...28,152,046
Ensembl chr20:28,114,404...28,121,807 		JBrowse link
G Chst7 carbohydrate sulfotransferase 7 involved_in IEA
ISO		 GO_REF:0000107
(PMID:10781596)		 Ensembl
RGD		 PMID:10781596 GO_REF:0000107 NCBI chr  X:2,396,260...2,432,828
Ensembl chr  X:2,393,874...2,432,840 		JBrowse link
G Chsy1 chondroitin sulfate synthase 1 acts_upstream_of_or_within
involved_in		 IEA
ISO		 GO_REF:0000107
(PMID:11514575)
(PMID:12716890)		 Ensembl
RGD		 PMID:11514575 PMID:12716890 GO_REF:0000107 NCBI chr 1:129,100,088...129,161,167
Ensembl chr 1:119,686,350...119,750,601 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:11514575), (PMID:12163485)		 Ensembl
RGD		 PMID:11514575 PMID:12163485 GO_REF:0000107 NCBI chr16:25,761,946...26,097,306
Ensembl chr16:21,235,784...21,330,319 		JBrowse link
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:11788602)
GO_REF:0000107
MGI:1927166 (PMID:21138417)		 RGD
Ensembl		 PMID:11788602 PMID:21138417 GO_REF:0000107 NCBI chr 4:151,271,774...151,308,856
Ensembl chr 4:151,277,645...151,308,839 		JBrowse link
G Cytl1 cytokine like 1 acts_upstream_of_or_within ISO
IEA		 (PMID:17644814)
GO_REF:0000107		 RGD
Ensembl		 PMID:17644814 GO_REF:0000107 NCBI chr14:73,053,876...73,058,886
Ensembl chr14:73,053,877...73,058,886 		JBrowse link
G Igf1 insulin-like growth factor 1 acts_upstream_of_or_within ISO (PMID:17644814) RGD PMID:17644814 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Pxylp1 2-phosphoxylose phosphatase 1 involved_in ISO
IEA
IBA
ISS		 (PMID:24425863)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000024		 RGD
Ensembl
GO_Central
UniProt		 PMID:24425863 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:106,299,303...106,364,603
Ensembl chr 8:97,419,776...97,485,064 		JBrowse link
G Slc35b2 solute carrier family 35 member B2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:35325049)		 Ensembl
RGD		 PMID:35325049 GO_REF:0000107 NCBI chr 9:15,438,594...15,442,227
Ensembl chr 9:15,438,594...15,442,234 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase involved_in IEA
ISS		 GO_REF:0000107
GO_REF:0000024		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr14:43,202,480...43,226,002
Ensembl chr14:42,848,854...42,872,354 		JBrowse link
G Xylt1 xylosyltransferase 1 involved_in ISO
IBA
ISS		 (PMID:17189265)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:17189265 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:181,078,222...181,361,047
Ensembl chr 1:171,643,925...171,926,783 		JBrowse link
G Xylt2 xylosyltransferase 2 involved_in ISO
IEA
IBA
ISS		 (PMID:17189265), (PMID:26027496)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000024		 RGD
Ensembl
GO_Central
UniProt		 PMID:17189265 PMID:26027496 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:80,102,776...80,116,346
Ensembl chr10:79,606,007...79,619,391 		JBrowse link
hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 involved_in IEA
ISO		 GO_REF:0000107
(PMID:17540771)		 Ensembl
RGD		 PMID:17540771 GO_REF:0000107 NCBI chr11:93,975,579...94,071,659
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Ccnd3 cyclin D3 IMP RGD PMID:19276076 RGD:2316018 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Has1 hyaluronan synthase 1 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:10455188), (PMID:8626618)
(PMID:10617644)		 GO_Central
Ensembl
RGD		 PMID:8626618 PMID:10455188 PMID:10617644 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397 		JBrowse link
G Has2 hyaluronan synthase 2 involved_in IEP
IEA
ISO
IBA		 PMID:19635555
GO_REF:0000107
(PMID:10455188), (PMID:10930438), (PMID:8798545)
GO_REF:0000033
(PMID:17324121), (PMID:20507985), (PMID:22016393), (PMID:30394292)
GO_REF:0000041		 Ensembl
RGD
GO_Central
UniProt		 PMID:8798545 PMID:10455188 PMID:10930438 PMID:17324121 PMID:20507985 More... GO_REF:0000033 GO_REF:0000041 GO_REF:0000107, RGD:8553259 NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Has3 hyaluronan synthase 3 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:16900089)
(PMID:9060470)
(PMID:10455188)
GO_REF:0000033		 RGD
GO_Central		 PMID:9060470 PMID:10455188 PMID:16900089 GO_REF:0000033 NCBI chr19:34,768,421...34,782,170
Ensembl chr19:34,771,982...34,782,592 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:15100360) RGD PMID:15100360 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
negative regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 involved_in ISO
IEA		 (PMID:23509262), (PMID:24251095)
GO_REF:0000107		 RGD
Ensembl		 PMID:23509262 PMID:24251095 GO_REF:0000107 NCBI chr 1:104,520,789...104,550,655
Ensembl chr 1:95,384,309...95,414,147 		JBrowse link
G Cltc clathrin heavy chain involved_in ISO
IEA
ISS		 (PMID:23509262), (PMID:24251095)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:23509262 PMID:24251095 GO_REF:0000024 GO_REF:0000107 NCBI chr10:72,014,984...72,073,308
Ensembl chr10:71,517,663...71,573,737 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO
IEA		 MGI:1856877 (PMID:22383528)
GO_REF:0000107		 RGD
Ensembl		 PMID:22383528 GO_REF:0000107 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
IEA
ISS		 (PMID:17324121)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17324121 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
positive regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor involved_in ISO
IEA		 (PMID:17324121)
GO_REF:0000107		 RGD
Ensembl		 PMID:17324121 GO_REF:0000107 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Has2 hyaluronan synthase 2 IDA
IMP		 RGD PMID:12186949 PMID:17080198 RGD:9588629, RGD:9588632 NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in ISO
IEA		 (PMID:17324121)
GO_REF:0000107		 RGD
Ensembl		 PMID:17324121 GO_REF:0000107 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in ISO
ISS
IEA		 (PMID:17324121)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:17324121 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:17080198 RGD:9588632 NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO
IEA		 MGI:1856877 (PMID:22383528)
GO_REF:0000107		 RGD
Ensembl		 PMID:22383528 GO_REF:0000107 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        macromolecule metabolic process 9996
          aminoglycan metabolic process 96
            aminoglycan biosynthetic process 52
              glycosaminoglycan biosynthetic process 43
                chondroitin sulfate proteoglycan biosynthetic process + 20
                hyaluronan biosynthetic process + 14
                peptidoglycan biosynthetic process + 0
paths to the root