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ONTOLOGY REPORT - ANNOTATIONS


Term:keratan sulfate biosynthetic process
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Accession:GO:0018146 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.
Synonyms:exact_synonym: keratan sulfate anabolism;   keratan sulfate biosynthesis;   keratan sulfate formation;   keratan sulfate synthesis;   keratan sulphate biosynthesis;   keratan sulphate biosynthetic process
 xref: RESID:AA0247



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keratan sulfate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gnt7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 involved_in ISO
ISS
(PMID:17690104)
(MGI:6151274|PMID:29625490)
GO_REF:0000024
RGD
UniProt
PMID:17690104 PMID:29625490 GO_REF:0000024 MGI:6151274 NCBI chr 9:86,956,220...86,960,171
Ensembl chr 9:86,956,220...86,960,170
JBrowse link
G B4galt4 beta-1,4-galactosyltransferase 4 involved_in ISO
ISS
(PMID:17690104), (PMID:32827291)
GO_REF:0000024
RGD
UniProt
PMID:17690104 PMID:32827291 GO_REF:0000024 NCBI chr11:61,995,807...62,021,751
Ensembl chr11:61,995,814...62,021,671
JBrowse link
G Chst1 carbohydrate sulfotransferase 1 involved_in ISO
ISS
(PMID:17690104)
GO_REF:0000024
RGD
UniProt
PMID:17690104 GO_REF:0000024 NCBI chr 3:78,552,059...78,574,740
Ensembl chr 3:78,548,525...78,574,883
JBrowse link
G Chst5 carbohydrate sulfotransferase 5 involved_in ISO
IBA
(MGI:1934540|PMID:11278593)
(PMID:11278593), (PMID:17690104)
GO_REF:0000033
RGD
GO_Central
PMID:11278593 PMID:17690104 GO_REF:0000033 MGI:1934540 NCBI chr19:39,860,729...39,881,019
Ensembl chr19:39,860,501...39,881,064
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11455
      cellular metabolic process 9554
        sulfur compound metabolic process 318
          sulfur compound biosynthetic process 143
            keratan sulfate biosynthetic process 4
Path 2
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11455
      macromolecule metabolic process 9273
        aminoglycan metabolic process 116
          glycosaminoglycan metabolic process 102
            mucopolysaccharide metabolic process 83
              keratan sulfate metabolic process 5
                keratan sulfate biosynthetic process 4
paths to the root