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ONTOLOGY REPORT - ANNOTATIONS

Term:heparin proteoglycan biosynthetic process
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Accession:GO:0030210 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate).
Synonyms:exact_synonym: heparin anabolism;   heparin biosynthesis;   heparin formation;   heparin synthesis
 related_synonym: heparan sulfate biosynthetic process


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heparin proteoglycan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 involved_in ISO
IEA 		(PMID:19297368)
GO_REF:0000107 		RGD
Ensembl		 PMID:19297368 GO_REF:0000107 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within_positive_effect IEA
ISO 		GO_REF:0000107
MGI:108050 (PMID:21148566), (PMID:21310272)
(PMID:10926768), (PMID:15161920), (PMID:15177029), (PMID:18480751) 		Ensembl
RGD		 PMID:10926768 PMID:15161920 PMID:15177029 PMID:18480751 PMID:21148566 More... GO_REF:0000107 NCBI chr 7:86,265,651...86,544,488
Ensembl chr 7:86,259,900...86,544,567 		JBrowse link
G Ext2 exostosin glycosyltransferase 2 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:894663 (PMID:21310272) 		Ensembl
RGD		 PMID:21310272 GO_REF:0000107 NCBI chr 3:100,120,776...100,253,424
Ensembl chr 3:100,120,776...100,253,596 		JBrowse link
G Glce glucuronic acid epimerase involved_in IEA
ISO 		GO_REF:0000041
GO_REF:0000107
(PMID:11279150) 		UniProt
Ensembl
RGD		 PMID:11279150 GO_REF:0000041 GO_REF:0000107 NCBI chr 8:71,441,607...71,507,639
Ensembl chr 8:71,441,616...71,507,587 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr18:56,407,308...56,470,007
Ensembl chr18:56,411,200...56,448,612 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr15:3,612,775...3,623,061
Ensembl chr15:3,612,775...3,623,061 		JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:214,386,804...214,552,739
Ensembl chr 2:214,389,447...214,539,164 		JBrowse link
G Ndst4 N-deacetylase and N-sulfotransferase 4 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:216,461,542...216,794,035
Ensembl chr 2:216,461,543...216,794,035 		JBrowse link
G Slc10a7 solute carrier family 10, member 7 involved_in ISO
IEA 		(PMID:30082715)
GO_REF:0000107 		RGD
Ensembl		 PMID:30082715 GO_REF:0000107 NCBI chr19:46,087,440...46,311,753
Ensembl chr19:46,049,631...46,311,753 		JBrowse link
G Xylt2 xylosyltransferase 2 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3714171 (PMID:17517600) 		Ensembl
RGD		 PMID:17517600 GO_REF:0000107 NCBI chr10:80,102,776...80,116,346
Ensembl chr10:80,102,873...80,116,257 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      metabolic process 11533
        carbohydrate derivative metabolic process 1021
          glycoprotein metabolic process 383
            proteoglycan metabolic process 105
              heparin proteoglycan metabolic process 17
                heparin proteoglycan biosynthetic process 10
                  glycosaminoglycan-protein linkage region biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      metabolic process 11533
        macromolecule metabolic process 9453
          protein metabolic process 4859
            glycoprotein metabolic process 383
              glycoprotein biosynthetic process 315
                protein O-linked glycosylation 145
                  protein O-linked glycosylation via xylose 58
                    heparin proteoglycan biosynthetic process 10
                      glycosaminoglycan-protein linkage region biosynthetic process 0
paths to the root