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ONTOLOGY REPORT - ANNOTATIONS

Term:hyaluronan biosynthetic process
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Accession:GO:0030213 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
Synonyms:exact_synonym: hyaluronan anabolism;   hyaluronan biosynthesis;   hyaluronan formation;   hyaluronan synthesis
 xref: Reactome:R-HSA-2142850 "Hyaluronan biosynthesis and export"


show annotations for term's descendants           Sort by:
hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 involved_in IEA
ISO		 GO_REF:0000107
(PMID:17540771)		 Ensembl
RGD		 PMID:17540771 GO_REF:0000107 NCBI chr11:93,975,579...94,071,659
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Ccnd3 cyclin D3 IMP RGD PMID:19276076 RGD:2316018 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Has1 hyaluronan synthase 1 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:10455188), (PMID:8626618)
(PMID:10617644)		 GO_Central
Ensembl
RGD		 PMID:8626618 PMID:10455188 PMID:10617644 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397 		JBrowse link
G Has2 hyaluronan synthase 2 involved_in IEP
IEA
ISO
IBA		 PMID:19635555
GO_REF:0000107
(PMID:10455188), (PMID:10930438), (PMID:8798545)
GO_REF:0000033
(PMID:17324121), (PMID:20507985), (PMID:22016393), (PMID:30394292)
GO_REF:0000041		 Ensembl
RGD
GO_Central
UniProt		 PMID:8798545 PMID:10455188 PMID:10930438 PMID:17324121 PMID:20507985 More... GO_REF:0000033 GO_REF:0000041 GO_REF:0000107, RGD:8553259 NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Has3 hyaluronan synthase 3 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:16900089)
(PMID:9060470)
(PMID:10455188)
GO_REF:0000033		 RGD
GO_Central		 PMID:9060470 PMID:10455188 PMID:16900089 GO_REF:0000033 NCBI chr19:34,768,421...34,782,170
Ensembl chr19:34,771,982...34,782,592 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:15100360) RGD PMID:15100360 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
negative regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 involved_in ISO
IEA		 (PMID:23509262), (PMID:24251095)
GO_REF:0000107		 RGD
Ensembl		 PMID:23509262 PMID:24251095 GO_REF:0000107 NCBI chr 1:104,520,789...104,550,655
Ensembl chr 1:95,384,309...95,414,147 		JBrowse link
G Cltc clathrin heavy chain involved_in ISO
IEA
ISS		 (PMID:23509262), (PMID:24251095)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:23509262 PMID:24251095 GO_REF:0000024 GO_REF:0000107 NCBI chr10:72,014,984...72,073,308
Ensembl chr10:71,517,663...71,573,737 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO
IEA		 MGI:1856877 (PMID:22383528)
GO_REF:0000107		 RGD
Ensembl		 PMID:22383528 GO_REF:0000107 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
IEA
ISS		 (PMID:17324121)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17324121 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
positive regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor involved_in ISO
IEA		 (PMID:17324121)
GO_REF:0000107		 RGD
Ensembl		 PMID:17324121 GO_REF:0000107 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Has2 hyaluronan synthase 2 IDA
IMP		 RGD PMID:12186949 PMID:17080198 RGD:9588629, RGD:9588632 NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in ISO
IEA		 (PMID:17324121)
GO_REF:0000107		 RGD
Ensembl		 PMID:17324121 GO_REF:0000107 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in ISO
ISS
IEA		 (PMID:17324121)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:17324121 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:17080198 RGD:9588632 NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO
IEA		 MGI:1856877 (PMID:22383528)
GO_REF:0000107		 RGD
Ensembl		 PMID:22383528 GO_REF:0000107 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        macromolecule metabolic process 9996
          aminoglycan metabolic process 96
            aminoglycan biosynthetic process 52
              glycosaminoglycan biosynthetic process 43
                hyaluronan biosynthetic process 14
                  negative regulation of hyaluronan biosynthetic process 4
                  positive regulation of hyaluronan biosynthetic process 5
                  regulation of hyaluronan biosynthetic process + 9
paths to the root