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ONTOLOGY REPORT - ANNOTATIONS


Term:hyaluronan biosynthetic process
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Accession:GO:0030213 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
Synonyms:exact_synonym: hyaluronan anabolism;   hyaluronan biosynthesis;   hyaluronan formation;   hyaluronan synthesis


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hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd3 cyclin D3 IMP RGD PMID:19276076 RGD:2316018 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Has1 hyaluronan synthase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:1351415|PMID:10617644)
RGD PMID:10617644, PMID:21873635 MGI:1351415, RGD:13792537 NCBI chr 1:59,720,612...59,732,409
Ensembl chr 1:59,720,612...59,732,409
JBrowse link
G Has2 hyaluronan synthase 2 involved_in IEP
ISO
IEA
IBA
PMID:19635555
(MGI:1861536|PMID:10930438)
GO_REF:0000041
PMID:21873635
(PMID:17324121), (PMID:22016393)
RGD
UniProt
PMID:10930438 PMID:17324121 PMID:22016393, PMID:19635555, PMID:21873635 GO_REF:0000041 MGI:1861536, RGD:8553259, RGD:13792537 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Has3 hyaluronan synthase 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:86804|PMID:9060470)
(PMID:16900089)
RGD PMID:9060470 PMID:16900089, PMID:21873635 MGI:86804, RGD:13792537 NCBI chr19:39,063,298...39,077,745
Ensembl chr19:39,063,998...39,077,722
JBrowse link
G Hyal1 hyaluronidase 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:21829529)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:21829529 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:116,332,834...116,337,522
Ensembl chr 8:116,332,796...116,335,435
JBrowse link
G Il1b interleukin 1 beta involved_in ISO
IEA
(PMID:15100360)
GO_REF:0000107
RGD
Ensembl
PMID:15100360 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
negative regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 involved_in ISO (PMID:23509262), (PMID:24251095) RGD PMID:23509262 PMID:24251095 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335
JBrowse link
G Cltc clathrin heavy chain involved_in ISO
ISS
(PMID:23509262), (PMID:24251095)
GO_REF:0000024
RGD
UniProt
PMID:23509262 PMID:24251095 GO_REF:0000024 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856877 (MGI:5320806|PMID:22383528)
Ensembl
RGD
PMID:22383528 GO_REF:0000107 MGI:5320806 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS
(PMID:17324121)
GO_REF:0000024
RGD
UniProt
PMID:17324121 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
positive regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor involved_in ISO (PMID:17324121) RGD PMID:17324121 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Has2 hyaluronan synthase 2 IDA
IMP
RGD PMID:12186949, PMID:17080198 RGD:9588629, RGD:9588632 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in ISO
IEA
(PMID:17324121)
GO_REF:0000107
RGD
Ensembl
PMID:17324121 GO_REF:0000107 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in ISO
ISS
IEA
(PMID:17324121)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:17324121 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:17080198 RGD:9588632 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
regulation of hyaluronan biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO MGI:1856877 (MGI:5320806|PMID:22383528) RGD PMID:22383528 MGI:5320806 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    metabolic process 11911
      organic substance metabolic process 11425
        macromolecule metabolic process 9877
          aminoglycan metabolic process 119
            aminoglycan biosynthetic process 61
              glycosaminoglycan biosynthetic process 48
                hyaluronan biosynthetic process 14
                  negative regulation of hyaluronan biosynthetic process 4
                  positive regulation of hyaluronan biosynthetic process 5
                  regulation of hyaluronan biosynthetic process + 9
Path 2
Term Annotations click to browse term
  biological_process 19634
    metabolic process 11911
      nitrogen compound metabolic process 10103
        organonitrogen compound metabolic process 6905
          aminoglycan metabolic process 119
            glycosaminoglycan metabolic process 100
              mucopolysaccharide metabolic process 79
                hyaluronan metabolic process 36
                  hyaluronan biosynthetic process 14
                    negative regulation of hyaluronan biosynthetic process 4
                    positive regulation of hyaluronan biosynthetic process 5
                    regulation of hyaluronan biosynthetic process + 9
paths to the root