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ONTOLOGY REPORT - ANNOTATIONS

Term:calcineurin-mediated signaling
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Accession:GO:0097720 term browser browse the term
Definition:Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression.
Synonyms:exact_synonym: calcineurin-mediated signalling
 related_synonym: calcineurin signaling


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calcineurin-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 involved_in ISO (PMID:8631777) RGD PMID:8631777 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 involved_in ISO (PMID:8631777) RGD PMID:8631777 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287 		JBrowse link
G Calm3 calmodulin 3 involved_in ISO (PMID:8631777) RGD PMID:8631777 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IMP RGD PMID:25057110 RGD:12904895 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G ENSRNOG00000067514 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr  X:145,949,526...145,951,349 JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 IMP RGD PMID:25057110 RGD:12904895 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 IMP RGD PMID:25057110 RGD:12904895 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in ISO
IEA		 (PMID:11005320)
GO_REF:0000002		 RGD
InterPro		 PMID:11005320 GO_REF:0000002 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000002
(PMID:11005320)		 UniProt
GO_Central
InterPro
RGD		 PMID:11005320 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981 		JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832 		JBrowse link
G Ppp3r2 protein phosphatase 3, regulatory subunit B, beta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:64,026,903...64,027,898
Ensembl chr 5:64,026,903...64,032,548 		JBrowse link
calcineurin-NFAT signaling cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrb2 adhesion G protein-coupled receptor B2 involved_in ISO (PMID:28891236) RGD PMID:28891236 NCBI chr 5:142,299,190...142,362,540
Ensembl chr 5:142,331,329...142,362,540 		JBrowse link
G Akap5 A-kinase anchoring protein 5 involved_in ISO (PMID:33941685) RGD PMID:33941685 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A IMP RGD PMID:21273244 RGD:401940178 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(PMID:18347059)		 Ensembl
RGD		 PMID:18347059 GO_REF:0000107 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(PMID:18347059)		 Ensembl
RGD		 PMID:18347059 GO_REF:0000107 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfam1 NFAT activating protein with ITAM motif 1 involved_in ISO (PMID:12615919) RGD PMID:12615919 NCBI chr 7:114,139,318...114,175,395
Ensembl chr 7:114,139,345...114,175,442 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:14979875)
GO_REF:0000033
(PMID:19233265)		 RGD
GO_Central		 PMID:14979875 PMID:19233265 GO_REF:0000033 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:107164 (PMID:18676376)
GO_REF:0000033		 RGD
GO_Central		 PMID:18676376 GO_REF:0000033 NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:107164|MGI:107172 (PMID:18676376), (PMID:19179536)
GO_REF:0000033		 RGD
GO_Central		 PMID:18676376 PMID:19179536 GO_REF:0000033 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:107172 (PMID:19179536)
GO_REF:0000033		 RGD
GO_Central		 PMID:19179536 GO_REF:0000033 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 involved_in ISO (PMID:33941685) RGD PMID:33941685 NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:15955804), (PMID:19154138), (PMID:22343722), (PMID:22688515), (PMID:23468591), (PMID:26248042)
MGI:102463|MGI:103296 (PMID:18676376), (PMID:19188439), (PMID:21427212), (PMID:9017603), (PMID:9515963), (PMID:9515964)
GO_REF:0000033		 RGD
GO_Central		 PMID:9017603 PMID:9515963 PMID:9515964 PMID:15955804 PMID:18676376 More... GO_REF:0000033 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta involved_in ISO (PMID:19154138), (PMID:22688515) RGD PMID:19154138 PMID:22688515 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981 		JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma involved_in ISO (PMID:19154138) RGD PMID:19154138 NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832 		JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:22688515)
GO_REF:0000033
MGI:103296|MGI:1920431 (PMID:19179536)		 RGD
GO_Central		 PMID:19179536 PMID:22688515 GO_REF:0000033 NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907 		JBrowse link
G Rcan1 regulator of calcineurin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1858219|MGI:3641540 (PMID:16648267)		 Ensembl
RGD		 PMID:16648267 GO_REF:0000107 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045 		JBrowse link
G Rcan2 regulator of calcineurin 2 acts_upstream_of_or_within ISO MGI:1890564|MGI:3641543 (PMID:16648267) RGD PMID:16648267 NCBI chr 9:16,959,478...17,174,823
Ensembl chr 9:16,959,480...17,174,856 		JBrowse link
G Tbc1d10c TBC1 domain family, member 10C acts_upstream_of ISO MGI:5578034 (PMID:23109291) RGD PMID:23109291 NCBI chr 1:201,476,258...201,484,876
Ensembl chr 1:201,477,157...201,564,920 		JBrowse link
G Tprg1l tumor protein p63 regulated 1-like acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:31787876)
GO_REF:0000107		 RGD
Ensembl		 PMID:31787876 GO_REF:0000107 NCBI chr 5:164,722,151...164,725,358
Ensembl chr 5:164,710,285...164,725,425 		JBrowse link
negative regulation of calcineurin-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppia peptidylprolyl isomerase A IDA RGD PMID:19832699 RGD:7247324 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
negative regulation of calcineurin-NFAT signaling cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO (PMID:24234654) RGD PMID:24234654 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012 		JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO
IMP		 (PMID:15955804), (PMID:19287093), (PMID:25147342)
(PMID:25147342)		 RGD PMID:15955804 PMID:19287093 PMID:25147342 PMID:19287093 RGD:10047333 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246 		JBrowse link
G Chp1 calcineurin-like EF-hand protein 1 involved_in ISO
IBA
ISS		 (PMID:10593895)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:10593895 GO_REF:0000024 GO_REF:0000033 NCBI chr 3:106,536,009...106,571,255
Ensembl chr 3:106,536,004...106,571,251 		JBrowse link
G Cmya5 cardiomyopathy associated 5 acts_upstream_of_or_within ISO MGI:107164 (PMID:21427212) RGD PMID:21427212 NCBI chr 2:24,279,520...24,378,253
Ensembl chr 2:24,279,528...24,378,364 		JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 involved_in ISO (PMID:16511445) RGD PMID:16511445 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106 		JBrowse link
G Fhl2 four and a half LIM domains 2 involved_in ISO
IBA
IEA
IMP		 (PMID:22851699)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:22851699 PMID:22851699 GO_REF:0000033 GO_REF:0000107, RGD:13601990 NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISO
IEA
ISS		 (PMID:9072970)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:9072970 GO_REF:0000024 GO_REF:0000107 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Homer2 homer scaffold protein 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:18218901)		 UniProt
Ensembl
RGD		 PMID:18218901 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:135,558,977...135,659,780
Ensembl chr 1:135,567,414...135,659,772 		JBrowse link
G Homer3 homer scaffold protein 3 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:18218901)		 UniProt
Ensembl
RGD		 PMID:18218901 GO_REF:0000024 GO_REF:0000107 NCBI chr16:19,132,177...19,142,739
Ensembl chr16:19,132,162...19,142,680 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:18347059)		 Ensembl
RGD		 PMID:18347059 GO_REF:0000107 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:18347059)		 Ensembl
RGD		 PMID:18347059 GO_REF:0000107 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myoz1 myozenin 1 involved_in ISO (PMID:18846255) RGD PMID:18846255 NCBI chr15:3,644,333...3,651,584
Ensembl chr15:3,644,368...3,652,884 		JBrowse link
G Myoz2 myozenin 2 involved_in ISO (PMID:15543153) RGD PMID:15543153 NCBI chr 2:211,141,463...211,168,187
Ensembl chr 2:211,141,463...211,168,221 		JBrowse link
G Prnp prion protein involved_in ISO (PMID:20145049) RGD PMID:20145049 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Rcan1 regulator of calcineurin 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:12809556)		 UniProt
Ensembl
RGD		 PMID:12809556 GO_REF:0000024 GO_REF:0000107 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045 		JBrowse link
G Tbc1d10c TBC1 domain family, member 10C acts_upstream_of_or_within ISO MGI:5578034 (PMID:23109291) RGD PMID:23109291 NCBI chr 1:201,476,258...201,484,876
Ensembl chr 1:201,477,157...201,564,920 		JBrowse link
positive regulation of calcineurin-NFAT signaling cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap5 A-kinase anchoring protein 5 involved_in IMP PMID:22343722 UniProt PMID:22343722 RGD:13507305 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578 		JBrowse link
G Akap6 A-kinase anchoring protein 6 involved_in IMP PMID:16306226 BHF-UCL PMID:16306226 RGD:2312613 NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738 		JBrowse link
G C16h10orf71 similar to human chromosome 10 open reading frame 71 involved_in IMP
ISO
IBA		 PMID:28717008
(PMID:28717008)
GO_REF:0000033		 RGD
GO_Central		 PMID:28717008 PMID:28717008 GO_REF:0000033, RGD:13602000 NCBI chr16:7,910,597...7,961,900
Ensembl chr16:7,910,433...7,961,958 		JBrowse link
G Camta1 calmodulin binding transcription activator 1 involved_in ISO (PMID:23853098) RGD PMID:23853098 NCBI chr 5:161,510,283...162,356,902
Ensembl chr 5:161,510,283...162,356,723 		JBrowse link
G Cherp calcium homeostasis endoplasmic reticulum protein involved_in ISO (PMID:12656674) RGD PMID:12656674 NCBI chr16:17,367,455...17,380,507
Ensembl chr16:17,367,455...17,380,507 		JBrowse link
G Chp2 calcineurin-like EF hand protein 2 involved_in ISO
IBA
IEA
ISS		 (PMID:18815128)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:18815128 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:176,757,945...176,772,443
Ensembl chr 1:176,757,876...176,772,139 		JBrowse link
G Cib1 calcium and integrin binding 1 involved_in ISO
IBA
IEA
IMP		 (PMID:20639889)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:20639889 PMID:20639889 GO_REF:0000033 GO_REF:0000107, RGD:8554486 NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:96083 (PMID:19179536)		 Ensembl
RGD		 PMID:19179536 GO_REF:0000107 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA		 (PMID:19654000)
GO_REF:0000107		 RGD
Ensembl		 PMID:19654000 GO_REF:0000107 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 involved_in ISO (PMID:20026769) RGD PMID:20026769 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046 		JBrowse link
G Nrg1 neuregulin 1 acts_upstream_of_or_within ISO MGI:95411 (PMID:19179536) RGD PMID:19179536 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Ptbp1 polypyrimidine tract binding protein 1 involved_in ISO (PMID:23853098) RGD PMID:23853098 NCBI chr 7:9,842,574...9,852,332
Ensembl chr 7:9,842,574...9,852,397 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 involved_in ISO (PMID:22688515) RGD PMID:22688515 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Sppl3 signal peptide peptidase like 3 involved_in ISO (PMID:25384971) RGD PMID:25384971 NCBI chr12:41,515,635...41,600,079
Ensembl chr12:41,515,640...41,600,126 		JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within ISO (PMID:16803872) RGD PMID:16803872 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
regulation of calcineurin-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc8a2 solute carrier family 8 member A2 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(PMID:29274751)		 Ensembl
RGD		 PMID:29274751 GO_REF:0000107 NCBI chr 1:76,816,583...76,852,928
Ensembl chr 1:76,808,725...76,847,072 		JBrowse link
regulation of calcineurin-NFAT signaling cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec7a C-type lectin domain containing 7A acts_upstream_of_or_within ISO (PMID:19136564) RGD PMID:19136564 NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897 		JBrowse link
G Efhb EF hand domain family, member B involved_in ISO (PMID:30481768) RGD PMID:30481768 NCBI chr 9:6,372,191...6,441,678
Ensembl chr 9:6,372,194...6,441,919 		JBrowse link
G Mir1 microRNA 1 acts_upstream_of_or_within ISO (PMID:19188439) RGD PMID:19188439 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mir1b microRNA 1b acts_upstream_of_or_within ISO (PMID:6466370) RGD PMID:6466370 NCBI chr 3:167,487,117...167,487,201
Ensembl chr 3:167,487,117...167,487,201 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 acts_upstream_of_or_within ISO (PMID:19188439) RGD PMID:19188439 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:19136564)		 Ensembl
RGD		 PMID:19136564 GO_REF:0000107 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      signal transduction 7180
        intracellular signal transduction 3073
          intracellular signaling cassette 2002
            calcium-mediated signaling 245
              calcineurin-mediated signaling 61
                calcineurin-NFAT signaling cascade + 51
                negative regulation of calcineurin-mediated signaling + 17
                positive regulation of calcineurin-mediated signaling + 15
                regulation of calcineurin-mediated signaling + 39
Path 2
Term Annotations click to browse term
  biological_process 20069
    biological regulation 13555
      regulation of biological process 13132
        signaling 7740
          signal transduction 7180
            intracellular signal transduction 3073
              intracellular signaling cassette 2002
                calcium-mediated signaling 245
                  calcineurin-mediated signaling 61
                    calcineurin-NFAT signaling cascade + 51
                    negative regulation of calcineurin-mediated signaling + 17
                    positive regulation of calcineurin-mediated signaling + 15
                    regulation of calcineurin-mediated signaling + 39
paths to the root