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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Sodium salicylate
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Accession:CHEBI:9180 term browser browse the term
Definition:An organic molecular entity that has formula C7H5O3.Na.
Synonyms:related_synonym: Formula=C7H5O3.Na;   InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1;   InChIKey=ABBQHOQBGMUPJH-UHFFFAOYSA-M;   SMILES=[Na+].Oc1ccccc1C([O-])=O
 xref: CAS:54-21-7;   KEGG:C07587;   KEGG:D00566
 xref_mesh: MESH:D012980


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Sodium salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa5 annexin A5 increases activity ISO Sodium Salicylate results in increased activity of ANXA5 protein CTD PMID:10090950 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Casp1 caspase 1 increases activity
multiple interactions		 EXP Sodium Salicylate results in increased activity of CASP1 protein
Sodium Salicylate inhibits the reaction [Paraquat results in decreased activity of CASP1 protein]		 CTD PMID:17561093 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 EXP
ISO		 Sodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP3 protein]
Sodium Salicylate results in increased expression of CASP3 mRNA
Sodium Salicylate promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of CASP3 mRNA]
Sodium Salicylate results in increased activity of CASP3 protein		 CTD PMID:10090950 PMID:17561093 PMID:29117515 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 EXP Sodium Salicylate results in increased activity of CASP8 protein
Sodium Salicylate inhibits the reaction [Paraquat results in increased activity of CASP8 protein]		 CTD PMID:17561093 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases activity ISO Sodium Salicylate results in decreased activity of CDKN1A protein CTD PMID:15190207 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO Sodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:10993886 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Foxo3 forkhead box O3 decreases phosphorylation
increases expression		 ISO Sodium Salicylate results in decreased phosphorylation of FOXO3 protein
Sodium Salicylate results in increased expression of FOXO3 protein		 CTD PMID:21303813 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gsn gelsolin increases cleavage ISO Sodium Salicylate results in increased cleavage of GSN protein CTD PMID:10090950 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Sodium Salicylate results in increased expression of H2AX mRNA CTD PMID:29117515 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Sodium Salicylate results in increased activity of HSF1 protein CTD PMID:10328874 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B affects expression ISO Sodium Salicylate affects the expression of HSPA1B protein CTD PMID:16184763 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] CTD PMID:10328874 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma decreases expression ISO Sodium Salicylate results in decreased expression of IFNG protein CTD PMID:21303813 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Sodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:10993886 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression
multiple interactions		 ISO Sodium Salicylate results in decreased expression of IKBKB protein modified form
Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein]		 CTD PMID:21303813 PMID:23504962 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] CTD PMID:10328874 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Sodium Salicylate results in decreased expression of IL1B protein
Sodium Salicylate results in decreased expression of IL1B mRNA		 CTD PMID:10328874 PMID:21303813 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Sodium Salicylate affects the reaction [IL4 results in increased activity of STAT6 protein]; Sodium Salicylate inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] CTD PMID:19767084 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO Sodium Salicylate results in decreased expression of IL6 protein
Sodium Salicylate inhibits the reaction [Palmitates results in increased secretion of IL6 protein]		 CTD PMID:21303813 PMID:23504962 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] CTD PMID:23504962 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] CTD PMID:23504962 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression		 EXP Sodium Salicylate inhibits the reaction [Paraquat results in increased expression of JUN protein]
Sodium Salicylate results in decreased expression of JUN protein		 CTD PMID:17561093 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO		 Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein		 CTD PMID:10357911 PMID:10993886 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:10357911 PMID:10993886 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Sodium Salicylate results in increased expression of MCL1 protein CTD PMID:10090950 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases localization
multiple interactions		 EXP
ISO		 Sodium Salicylate results in decreased localization of NFKB1 protein
Sodium Salicylate inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]		 CTD PMID:9281604 PMID:17259377 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:16936242 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 ISO Sodium Salicylate results in decreased expression of NOS2 protein
[Sodium Salicylate results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide		 CTD PMID:10860828 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases phosphorylation
multiple interactions		 ISO Sodium Salicylate results in increased phosphorylation of NOS3 protein
Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]]		 CTD PMID:21303813 PMID:23504962 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
increases expression
multiple interactions		 ISO Sodium Salicylate results in increased cleavage of PARP1 protein
Sodium Salicylate results in increased expression of PARP1 mRNA
Sodium Salicylate inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of PARP1 mRNA]		 CTD PMID:9694730 PMID:10090950 PMID:29117515 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pepd peptidase D decreases activity ISO Sodium Salicylate results in decreased activity of PEPD protein CTD PMID:16991207 NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
decreases activity
multiple interactions		 ISO Sodium Salicylate results in increased expression of PTGS2 mRNA; Sodium Salicylate results in increased expression of PTGS2 protein
Sodium Salicylate results in decreased activity of PTGS2 protein
12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; 12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein]; [PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; [PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein]; Hydrogen Peroxide affects the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein]; Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]		 CTD PMID:12538810 PMID:14742690 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases localization		 ISO
EXP		 Sodium Salicylate inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]
Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Sodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of RELA protein]
Sodium Salicylate results in decreased localization of RELA protein		 CTD PMID:9281604 PMID:10328874 PMID:17259377 PMID:23504962 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO Sodium Salicylate inhibits the reaction [SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]; Sodium Salicylate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein CTD PMID:10993886 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
increases expression		 ISO Sodium Salicylate results in decreased expression of SCARB1 protein
Sodium Salicylate results in increased expression of SCARB1 protein		 CTD PMID:16816107 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Slc26a5 solute carrier family 26 member 5 increases expression EXP Sodium Salicylate results in increased expression of SLC26A5 mRNA; Sodium Salicylate results in increased expression of SLC26A5 protein CTD PMID:19173110 NCBI chr 4:13,210,260...13,249,289
Ensembl chr 4:13,210,260...13,249,289 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Sodium Salicylate results in increased expression of SOD2 protein CTD PMID:21303813 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Sodium Salicylate affects the reaction [IL4 results in increased activity of STAT6 protein]; Sodium Salicylate inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] CTD PMID:19767084 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 Sodium Salicylate inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sodium Salicylate inhibits the reaction [Palmitates results in increased secretion of TNF protein]
Sodium Salicylate results in decreased expression of TNF protein		 CTD PMID:9281604 PMID:10328874 PMID:10357911 PMID:17568627 PMID:21303813 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Sodium Salicylate inhibits the reaction [Paraquat results in increased expression of TP53 protein] CTD PMID:17561093 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
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  CHEBI ontology 19841
    chemical entity 19839
      atom 19839
        nonmetal atom 19777
          carbon atom 19733
            organic molecular entity 19733
              Sodium salicylate 40
Path 2
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  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            Sodium salicylate 40
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