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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Gastrodin
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Accession:CHEBI:80828 term browser browse the term
Definition:A glycoside that has formula C13H18O7.
Synonyms:related_synonym: 4-(Hydroxymethyl)phenyl-beta-D-glucopyranoside;   Formula=C13H18O7;   InChI=1S/C13H18O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1;   InChIKey=PUQSUZTXKPLAPR-UJPOAAIJSA-N;   SMILES=OC[C@H]1O[C@@H](Oc2ccc(CO)cc2)[C@H](O)[C@@H](O)[C@@H]1O
 xref: CAS:62499-27-8;   KEGG:C16964
 xref_mesh: MESH:C045345


show annotations for term's descendants           Sort by:
Gastrodin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA] CTD PMID:26634892 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:26634892 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO gastrodin inhibits the reaction [Glutamic Acid results in increased expression of ACSL4 protein] CTD PMID:31698019 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO		 gastrodin inhibits the reaction [Glucose results in increased expression of BAX protein] CTD PMID:33764184 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 gastrodin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; gastrodin promotes the reaction [RELA protein binds to BCL2 promoter]
gastrodin results in increased expression of BCL2 mRNA		 CTD PMID:23578476 PMID:33764184 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO gastrodin results in increased expression of BCL2L1 mRNA CTD PMID:23578476 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 affects activity
multiple interactions		 ISO
EXP		 gastrodin affects the activity of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]]; [gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]; gastrodin inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]; Lithium Chloride affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]]		 CTD PMID:23578476 PMID:33645131 PMID:33764184 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 affects activity ISO gastrodin affects the activity of CASP9 protein CTD PMID:23578476 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [gastrodin inhibits the reaction [Glucose results in decreased activity of CAT protein]]; gastrodin inhibits the reaction [Glucose results in decreased activity of CAT protein]; NFE2L2 protein affects the reaction [gastrodin inhibits the reaction [Glucose results in decreased activity of CAT protein]] CTD PMID:33764184 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:26634892 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] CTD PMID:26634892 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO
EXP		 [Glucose co-treated with gastrodin] affects the expression of GCLC mRNA CTD PMID:33764184 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO
EXP		 [Glucose co-treated with gastrodin] affects the expression of GCLM mRNA CTD PMID:33764184 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP gastrodin inhibits the reaction [Rotenone results in increased expression of GJA1 mRNA]; gastrodin inhibits the reaction [Rotenone results in increased expression of GJA1 protein]; gastrodin inhibits the reaction [Rotenone results in increased phosphorylation of GJA1 protein] CTD PMID:23783886 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of GPX4 mRNA]; gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of GPX4 protein] CTD PMID:31698019 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Gastrodin inhibits the reaction [Complete Freund's adjuvant increases expression of Gria1 protein in the anterior cingulate cortex] RGD PMID:27816787 RGD:405650587 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions		 ISO
EXP		 gastrodin results in increased phosphorylation of GSK3B protein
gastrodin inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]		 CTD PMID:33764184 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of HMGB1 protein] CTD PMID:31468582 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 gastrodin results in increased expression of HMOX1 protein
[gastrodin co-treated with Dietary Fats] results in increased expression of HMOX1 protein; gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of HMOX1 protein]
[gastrodin co-treated with Oleic Acid] results in increased expression of HMOX1 protein; dorsomorphin inhibits the reaction [[gastrodin co-treated with Oleic Acid] results in increased expression of HMOX1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]]; [gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]; gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in decreased expression of HMOX1 protein]; Lithium Chloride affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]]		 CTD PMID:26634892 PMID:31468582 PMID:31698019 PMID:33645131 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases expression
multiple interactions		 EXP Gastrodin increases expression of Htr1a protein in the hippocampal formation
Gastrodin inhibits the reaction [3,3' -Iminodipropionitrile decreases expression of Htr1a protein in the hippocampal formation]		 RGD PMID:26899441 PMID:25817367 RGD:405866358, RGD:405866362 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Ifng interferon gamma affects expression ISO gastrodin affects the expression of IFNG protein CTD PMID:23578476 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of IL1B protein]; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL1B protein] CTD PMID:30790395 PMID:31468582 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 affects expression
multiple interactions
increases expression		 ISO gastrodin affects the expression of IL2 protein
gastrodin promotes the reaction [RELA protein binds to IL2 promoter]
gastrodin results in increased expression of IL2 mRNA		 CTD PMID:23578476 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 affects expression ISO gastrodin affects the expression of IL4 protein CTD PMID:23578476 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 gastrodin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]
dorsomorphin inhibits the reaction [gastrodin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA]]; gastrodin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA]
gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of IL6 protein]; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL6 protein]		 CTD PMID:26634892 PMID:30790395 PMID:31468582 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK8 protein] CTD PMID:30790395 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO
EXP		 gastrodin inhibits the reaction [Glucose results in decreased phosphorylation of MTOR protein] CTD PMID:33764184 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of MYD88 protein] CTD PMID:30790395 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO
EXP		 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [[Glucose co-treated with gastrodin] affects the localization of NFE2L2 protein]; [gastrodin co-treated with Dietary Fats] results in increased phosphorylation of NFE2L2 protein; [Glucose co-treated with gastrodin] affects the localization of NFE2L2 protein; gastrodin affects the reaction [Glutamic Acid affects the localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [gastrodin inhibits the reaction [Glucose results in decreased activity of CAT protein]]
[gastrodin co-treated with Oleic Acid] results in increased phosphorylation of and affects the localization of NFE2L2 protein; dorsomorphin inhibits the reaction [[gastrodin co-treated with Oleic Acid] results in increased phosphorylation of and affects the localization of NFE2L2 protein]; gastrodin results in increased phosphorylation of and affects the localization of NFE2L2 protein
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [[Glucose co-treated with gastrodin] affects the localization of NFE2L2 protein]; [Glucose co-treated with gastrodin] affects the localization of NFE2L2 protein; gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [gastrodin inhibits the reaction [Glucose results in decreased activity of CAT protein]]
gastrodin results in increased expression of NFE2L2 protein		 CTD PMID:26634892 PMID:31468582 PMID:31698019 PMID:33764184 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased phosphorylation of NFKBIA protein] CTD PMID:31468582 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]]; [gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]; Lithium Chloride affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]] CTD PMID:33645131 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO
EXP		 [Glucose co-treated with gastrodin] affects the expression of PRDX1 mRNA CTD PMID:33764184 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in increased expression of PTGS2 mRNA]; gastrodin inhibits the reaction [Glutamic Acid results in increased expression of PTGS2 mRNA]; gastrodin inhibits the reaction [Glutamic Acid results in increased expression of PTGS2 protein]
dorsomorphin inhibits the reaction [gastrodin inhibits the reaction [Oleic Acid results in increased expression of PTGS2 mRNA]]; gastrodin inhibits the reaction [Oleic Acid results in increased expression of PTGS2 mRNA]		 CTD PMID:26634892 PMID:31698019 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 gastrodin promotes the reaction [RELA protein binds to BCL2 promoter]; gastrodin promotes the reaction [RELA protein binds to IL2 promoter]
gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased phosphorylation of RELA protein]; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein]		 CTD PMID:23578476 PMID:30790395 PMID:31468582 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO
EXP		 gastrodin inhibits the reaction [Glucose results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:33764184 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of SLC40A1 protein] CTD PMID:31698019 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in decreased expression of SOD1 mRNA]
gastrodin inhibits the reaction [Oleic Acid results in decreased expression of SOD1 mRNA]		 CTD PMID:26634892 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO gastrodin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:26634892 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO gastrodin results in increased phosphorylation of STK11 protein CTD PMID:26634892 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TLR4 protein] CTD PMID:30790395 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 gastrodin inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]
dorsomorphin inhibits the reaction [gastrodin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]]; gastrodin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]
gastrodin inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of TNF protein]; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TNF protein]		 CTD PMID:26634892 PMID:30790395 PMID:31468582 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions EXP
ISO		 [Glucose co-treated with gastrodin] affects the expression of TXNRD1 mRNA CTD PMID:33764184 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    chemical entity 19867
      atom 19888
        nonmetal atom 19789
          oxygen atom 19549
            oxygen molecular entity 19529
              organooxygen compound 19180
                carbohydrates and carbohydrate derivatives 15283
                  carbohydrate derivative 14317
                    glycosyl compound 13080
                      glycoside 11832
                        Gastrodin 42
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            heteroorganic entity 19502
                              organochalcogen compound 19264
                                organooxygen compound 19180
                                  carbohydrates and carbohydrate derivatives 15283
                                    carbohydrate 15304
                                      carbohydrate derivative 14317
                                        glycosyl compound 13080
                                          glycoside 11832
                                            Gastrodin 42
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