CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: phthalaldehyde
Accession: CHEBI:70851
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Definition: A dialdehyde in which two formyl groups are attached to adjacent carbon centres on a benzene ring.
Synonyms: exact_synonym: benzene-1,2-dicarbaldehyde
related_synonym: 1,2-Benzenedicarboxaldehyde; 1,2-Diformylbenzene; Formula=C8H6O2; InChI=1S/C8H6O2/c9-5-7-3-1-2-4-8(7)6-10/h1-6H; InChIKey=ZWLUXSQADUDCSB-UHFFFAOYSA-N; OPA; OPTA; Phthalaldialdehyde; Phthaldialdehyde; Phthalic aldehyde; Phthalic dialdehyde; Phthalic dicarboxaldehyde; Phthalyldicarboxaldehyde; SMILES=O=Cc1ccccc1C=O; o-Phthaldehyde; o-Phthaldialdehyde; o-Phthalicdicarboxaldehyde; o-phthalaldehyde
xref: CAS:643-79-8
xref_mesh: MESH:D009764
xref: MetaCyc:CPD-15790; PMID:22125154; PMID:22142597; PMID:22209913; PMID:22265492; PMID:22274813; PMID:22302311; PMID:22362604; PMID:22365687; PMID:22386808; PMID:22387681; PMID:22456683; PMID:22475518; PMID:22565021; PMID:22655374; PMID:22679834; PMID:22727326; PMID:22750687; PMID:22919412; PMID:22940347; PMID:22953887; PMID:22980868; PMID:23017876; PMID:23018892; PMID:23055332; PMID:23084889; PMID:23099097; Reaxys:878317; Wikipedia:Phthalaldehyde
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Aicda
activation-induced cytidine deaminase
affects expression
ISO
o-Phthalaldehyde affects the expression of AICDA mRNA
CTD
PMID:22302311
NCBI chr 4:157,446,120...157,455,958
Ensembl chr 4:155,774,132...155,783,972
G
Akr1c3
aldo-keto reductase family 1, member C3
affects expression
ISO
o-Phthalaldehyde affects the expression of AKR1C18 mRNA
CTD
PMID:22302311
NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873
G
Ccl9
C-C motif chemokine ligand 9
affects expression
ISO
o-Phthalaldehyde affects the expression of CCL6 mRNA
CTD
PMID:22302311
NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,366,487...68,371,369
G
Ccna2
cyclin A2
affects expression
ISO
o-Phthalaldehyde affects the expression of CCNA2 mRNA
CTD
PMID:22302311
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
G
Ccnb1
cyclin B1
affects expression
ISO
o-Phthalaldehyde affects the expression of CCNB1 mRNA
CTD
PMID:22302311
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
G
Ccne2
cyclin E2
affects expression
ISO
o-Phthalaldehyde affects the expression of CCNE2 mRNA
CTD
PMID:22302311
NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:24,284,922...24,297,632
G
Ccr4
C-C motif chemokine receptor 4
affects expression
ISO
o-Phthalaldehyde affects the expression of CCR4 mRNA
CTD
PMID:22302311
NCBI chr 8:123,054,505...123,060,244
Ensembl chr 8:114,176,974...114,178,056
G
Cd207
CD207 molecule
affects expression
ISO
o-Phthalaldehyde affects the expression of CD207 mRNA
CTD
PMID:22302311
NCBI chr 4:116,155,229...116,161,587
Ensembl chr 4:116,155,212...116,161,518
G
Cd5l
Cd5 molecule-like
affects expression
ISO
o-Phthalaldehyde affects the expression of CD5L mRNA
CTD
PMID:22302311
NCBI chr 2:175,088,915...175,099,928
Ensembl chr 2:172,790,934...172,829,753
G
Cd83
CD83 molecule
affects expression
ISO
o-Phthalaldehyde affects the expression of CD83 mRNA
CTD
PMID:22302311
NCBI chr17:21,093,281...21,113,223
Ensembl chr17:20,887,309...20,907,083
G
Cdc20
cell division cycle 20
affects expression
ISO
o-Phthalaldehyde affects the expression of CDC20 mRNA
CTD
PMID:22302311
NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:131,966,215...131,970,512
G
Cdc25c
cell division cycle 25C
affects expression
ISO
o-Phthalaldehyde affects the expression of CDC25C mRNA
CTD
PMID:22302311
NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185
G
Cdk1
cyclin-dependent kinase 1
affects expression
ISO
o-Phthalaldehyde affects the expression of CDK1 mRNA
CTD
PMID:22302311
NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
G
Clec7a
C-type lectin domain containing 7A
affects expression
ISO
o-Phthalaldehyde affects the expression of CLEC7A mRNA
CTD
PMID:22302311
NCBI chr 4:164,588,737...164,599,953
Ensembl chr 4:162,902,732...162,913,897
G
Col8a1
collagen type VIII alpha 1 chain
affects expression
ISO
o-Phthalaldehyde affects the expression of COL8A1 mRNA
CTD
PMID:22302311
NCBI chr11:56,245,998...56,378,586
Ensembl chr11:42,777,628...42,906,424
G
Cphx1
cytoplasmic polyadenylated homeobox 1
affects expression
ISO
o-Phthalaldehyde affects the expression of CPHX1 mRNA
CTD
PMID:22302311
NCBI chr16:1,533,883...1,537,248
Ensembl chr16:1,528,440...1,537,082
G
Ctla4
cytotoxic T-lymphocyte-associated protein 4
affects expression
ISO
o-Phthalaldehyde affects the expression of CTLA4 mRNA
CTD
PMID:22302311
NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:62,319,312...62,324,963
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases expression
ISO
o-Phthalaldehyde results in decreased expression of CYP1A1 mRNA
CTD
PMID:20112102
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases expression
ISO
o-Phthalaldehyde results in decreased expression of CYP2E1 mRNA
CTD
PMID:20112102
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
G
Dio1
iodothyronine deiodinase 1
decreases activity
ISO
o-Phthalaldehyde results in decreased activity of DIO1 protein
CTD
PMID:30561685
NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:122,074,279...122,090,970
G
Dio2
iodothyronine deiodinase 2
decreases activity
ISO
o-Phthalaldehyde results in decreased activity of DIO2 protein
CTD
PMID:30561685
NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:109,665,523...109,679,809
G
Dio3
iodothyronine deiodinase 3
decreases activity
ISO
o-Phthalaldehyde results in decreased activity of DIO3 protein
CTD
PMID:30561685
NCBI chr 6:135,107,072...135,108,933
Ensembl chr 6:129,285,749...129,286,660
G
E2f1
E2F transcription factor 1
affects expression
ISO
o-Phthalaldehyde affects the expression of E2F1 mRNA
CTD
PMID:22302311
NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361
G
Fabp7
fatty acid binding protein 7
affects expression
ISO
o-Phthalaldehyde affects the expression of FABP7 mRNA
CTD
PMID:22302311
NCBI chr20:37,667,125...37,673,299
Ensembl chr20:37,123,193...37,126,880
G
Fxyd4
FXYD domain-containing ion transport regulator 4
affects expression
ISO
o-Phthalaldehyde affects the expression of FXYD4 mRNA
CTD
PMID:22302311
NCBI chr 4:152,782,181...152,786,118
Ensembl chr 4:151,109,779...151,113,637
G
Gzmb
granzyme B
affects expression
ISO
o-Phthalaldehyde affects the expression of GZMB mRNA
CTD
PMID:22302311
NCBI chr15:34,459,007...34,462,469
Ensembl chr15:30,173,603...30,346,814
G
Ifng
interferon gamma
increases expression
ISO
o-Phthalaldehyde results in increased expression of IFNG mRNA
CTD
PMID:21785612
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
G
Il10
interleukin 10
increases expression
ISO
o-Phthalaldehyde results in increased expression of IL10 mRNA
CTD
PMID:21785612
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
G
Il12b
interleukin 12B
affects expression
ISO
o-Phthalaldehyde affects the expression of IL12B mRNA
CTD
PMID:22302311
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
G
Il13
interleukin 13
increases expression
ISO
o-Phthalaldehyde results in increased expression of IL13 mRNA
CTD
PMID:21785612
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737
G
Il1b
interleukin 1 beta
increases expression
ISO
o-Phthalaldehyde results in increased expression of IL1B mRNA
CTD
PMID:21785612
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Il21
interleukin 21
affects expression
ISO
o-Phthalaldehyde affects the expression of IL21 mRNA
CTD
PMID:22302311
NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:120,119,444...120,126,996
G
Il2ra
interleukin 2 receptor subunit alpha
affects expression
ISO
o-Phthalaldehyde affects the expression of IL2RA mRNA
CTD
PMID:22302311
NCBI chr17:71,759,802...71,808,475
Ensembl chr17:66,849,974...66,898,697
G
Il4
interleukin 4
affects expression increases expression
ISO
o-Phthalaldehyde affects the expression of IL4 mRNA o-Phthalaldehyde results in increased expression of IL4 mRNA; o-Phthalaldehyde results in increased expression of IL4 protein
CTD
PMID:19110043 PMID:20176622 PMID:21785612 PMID:22302311
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
G
Il5
interleukin 5
increases expression
ISO
o-Phthalaldehyde results in increased expression of IL5 mRNA
CTD
PMID:19110043 PMID:21785612
NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213
G
Itgav
integrin subunit alpha V
affects expression
ISO
o-Phthalaldehyde affects the expression of ITGAV mRNA
CTD
PMID:22302311
NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:68,838,189...68,926,639
G
Iyd
iodotyrosine deiodinase
multiple interactions
ISO
o-Phthalaldehyde inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]
CTD
PMID:33352258
NCBI chr 1:42,410,099...42,425,414
Ensembl chr 1:40,004,041...40,019,319
G
Lgals7
galectin 7
affects expression
ISO
o-Phthalaldehyde affects the expression of LGALS7 mRNA
CTD
PMID:22302311
NCBI chr 1:93,275,092...93,279,529
Ensembl chr 1:84,150,252...84,152,015
G
Mki67
marker of proliferation Ki-67
affects expression
ISO
o-Phthalaldehyde affects the expression of MKI67 mRNA
CTD
PMID:22302311
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
G
Nts
neurotensin
affects expression
ISO
o-Phthalaldehyde affects the expression of NTS mRNA
CTD
PMID:22302311
NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:37,564,533...37,574,423
G
Thbs1
thrombospondin 1
affects expression
ISO
o-Phthalaldehyde affects the expression of THBS1 mRNA
CTD
PMID:22302311
NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440
G
Thbs4
thrombospondin 4
affects expression
ISO
o-Phthalaldehyde affects the expression of THBS4 mRNA
CTD
PMID:22302311
NCBI chr 2:25,718,219...25,760,345
Ensembl chr 2:23,983,158...24,026,313
G
Timd2
T-cell immunoglobulin and mucin domain containing 2
affects expression
ISO
o-Phthalaldehyde affects the expression of TIMD2 mRNA
CTD
PMID:22302311
NCBI chr10:31,561,563...31,602,515
Ensembl chr10:31,060,326...31,094,623
G
Timp1
TIMP metallopeptidase inhibitor 1
affects expression
ISO
o-Phthalaldehyde affects the expression of TIMP1 mRNA
CTD
PMID:22302311
NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664
G
Tnf
tumor necrosis factor
increases expression
ISO
o-Phthalaldehyde results in increased expression of TNF mRNA
CTD
PMID:21785612
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
affects activity
ISO
o-Phthalaldehyde affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
G
Trpm6
transient receptor potential cation channel, subfamily M, member 6
affects expression
ISO
o-Phthalaldehyde affects the expression of TRPM6 mRNA
CTD
PMID:22302311
NCBI chr 1:225,559,528...225,747,106
Ensembl chr 1:216,170,038...216,320,520
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