.
roflumilast - Ontology Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:roflumilast
go back to main search page
Accession:CHEBI:47657 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid with the amino group of 3,5-dichloropyridin-4-amine. Used for treatment of bronchial asthma and chronic obstructive pulmonary disease.
Synonyms:related_synonym: 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE;   Daliresp;   Formula=C17H14Cl2F2N2O3;   InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24);   InChIKey=MNDBXUUTURYVHR-UHFFFAOYSA-N;   SMILES=FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl;   roflumilastum
 alt_id: MESH:C424423
 xref: CAS:162401-32-3;   Drug_Central:3531;   KEGG:D05744
 xref_mesh: MESH:C424423
 xref: PDBeChem:ROF;   PMID:21778965;   PMID:21913898;   PMID:21965226;   PMID:22041526;   PMID:22258322;   PMID:22284994;   PMID:22306235;   PMID:22364166;   PMID:22385203;   PMID:22421519;   PMID:22425388;   PMID:22433610;   PMID:22452977;   PMID:22500119;   PMID:22605906;   PMID:22723325;   PMID:22790061;   PMID:22791991;   PMID:22833385;   PMID:22952743;   PMID:22955248;   PMID:22997924;   Patent:US2008181876;   Patent:US2008221111;   Patent:WO2008017827;   Patent:WO2008090355;   Reaxys:9802592;   Wikipedia:Roflumilast

1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
X
Y

show annotations for term's descendants           Sort by:
roflumilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:39197814 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; RAPGEF3 mutant form inhibits the reaction [Roflumilast results in increased phosphorylation of AKT1 protein]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein] CTD PMID:18276108 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein] CTD PMID:31301536 NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540 		JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO
EXP		 Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein] CTD PMID:31301536 NCBI chr15:99,488,909...99,492,710
Ensembl chr15:99,488,663...99,492,710 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Roflumilast inhibits the reaction [Rotenone results in increased expression of ATF6 protein] CTD PMID:37105514 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340 		JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions		 ISO Roflumilast results in increased expression of BAX mRNA; Roflumilast results in increased expression of BAX protein
[Cisplatin co-treated with Roflumilast] results in increased expression of BAX mRNA; Cisplatin promotes the reaction [Roflumilast results in increased expression of BAX mRNA]; Cisplatin promotes the reaction [Roflumilast results in increased expression of BAX protein]; Roflumilast promotes the reaction [Cisplatin results in increased expression of BAX protein]
Roflumilast inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Roflumilast inhibits the reaction [Cisplatin results in increased expression of BAX protein]		 CTD PMID:33757793 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression		 ISO Roflumilast inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Roflumilast inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
Roflumilast results in decreased expression of BCL2 mRNA; Roflumilast results in decreased expression of BCL2 protein
Cisplatin promotes the reaction [Roflumilast results in decreased expression of BCL2 mRNA]; Cisplatin promotes the reaction [Roflumilast results in decreased expression of BCL2 protein]; Roflumilast promotes the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Roflumilast promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]		 CTD PMID:33757793 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions ISO Roflumilast inhibits the reaction [Rotenone results in decreased expression of BDNF protein] CTD PMID:36706892 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity
decreases expression		 ISO Roflumilast results in increased expression of CASP3 mRNA
Roflumilast inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Roflumilast inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; Roflumilast inhibits the reaction [Rotenone results in increased expression of CASP3 protein]
[Cisplatin co-treated with Roflumilast] results in increased expression of CASP3 mRNA; Cisplatin promotes the reaction [Roflumilast results in increased activity of CASP3 protein]; Cisplatin promotes the reaction [Roflumilast results in increased expression of CASP3 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased activity of CASP3 protein]
Roflumilast results in decreased expression of CASP3 protein		 CTD PMID:33757793 PMID:37105514 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase multiple interactions ISO Roflumilast inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Roflumilast inhibits the reaction [Rotenone results in decreased activity of CAT protein] CTD PMID:33757793 PMID:36706892 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:21913898 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:21913898 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein] CTD PMID:21913898 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein] CTD PMID:39197814 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CDKN1A protein] CTD PMID:39197814 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions EXP
ISO		 Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein] CTD PMID:31301536 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Cnn1 calponin 1 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CNN1 protein] CTD PMID:39197814 NCBI chr 9:22,010,501...22,020,517
Ensembl chr 9:22,010,512...22,020,926 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions EXP
ISO		 Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of COL1A1 mRNA]; Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of COL1A1 protein]
Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]		 CTD PMID:39197814 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation		 ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; Roflumilast inhibits the reaction [Rotenone results in decreased phosphorylation of CREB1 protein]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]
Roflumilast results in increased phosphorylation of CREB1 protein		 CTD PMID:18276108 PMID:36706892 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein] CTD PMID:21913898 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Roflumilast inhibits the reaction [Rotenone results in increased expression of DDIT3 protein] CTD PMID:37105514 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Fap fibroblast activation protein multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of FAP protein] CTD PMID:39197814 NCBI chr 2:62,331,280...62,404,365
Ensembl chr 2:62,331,287...62,404,419 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP
ISO		 Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of FN1 protein]
Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]		 CTD PMID:39197814 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased activity of GLB1 protein] CTD PMID:39197814 NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Roflumilast inhibits the reaction [Rotenone results in decreased expression of HMOX1 protein]; Roflumilast promotes the reaction [Cisplatin results in increased activity of HMOX1 protein]; Roflumilast promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]
Cisplatin promotes the reaction [Roflumilast results in increased expression of HMOX1 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]		 CTD PMID:33757793 PMID:37105514 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Roflumilast inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:33757793 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Roflumilast inhibits the reaction [Rotenone results in increased expression of IL6 protein] CTD PMID:36706892 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO		 Roflumilast inhibits the reaction [Hypochlorous Acid results in increased phosphorylation of MAPK1 protein]
KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]]		 CTD PMID:39197814 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP		 KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]]
Roflumilast inhibits the reaction [Hypochlorous Acid results in increased phosphorylation of MAPK3 protein]		 CTD PMID:39197814 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions		 ISO Roflumilast results in increased expression of NFE2L2 mRNA
[Roflumilast co-treated with Rotenone] results in increased expression of and results in increased localization of NFE2L2 protein; Roflumilast promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]
Cisplatin promotes the reaction [Roflumilast results in increased expression of NFE2L2 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]		 CTD PMID:33757793 PMID:37105514 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO Roflumilast inhibits the reaction [Rotenone results in decreased expression of NGF protein] CTD PMID:36706892 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein] CTD PMID:39197814 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions		 ISO Roflumilast results in increased expression of NQO1 mRNA
Roflumilast promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]
Cisplatin promotes the reaction [Roflumilast results in increased expression of NQO1 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]		 CTD PMID:33757793 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Pde3a phosphodiesterase 3A, cGMP inhibited decreases activity ISO Roflumilast results in decreased activity of PDE3A protein CTD PMID:15901792 NCBI chr 6:141,194,995...141,452,588
Ensembl chr 6:141,194,995...141,453,174 		JBrowse link
G Pde3b phosphodiesterase 3B, cGMP-inhibited decreases activity ISO Roflumilast results in decreased activity of PDE3B protein CTD PMID:15901792 NCBI chr 7:114,014,388...114,137,173
Ensembl chr 7:114,014,516...114,138,486 		JBrowse link
G Pde4a phosphodiesterase 4A, cAMP specific decreases activity
multiple interactions		 ISO Roflumilast results in decreased activity of PDE4A protein
Roflumilast inhibits the reaction [Rotenone results in increased activity of PDE4A protein]		 CTD PMID:15901792 PMID:36706892 NCBI chr 9:21,076,998...21,124,544
Ensembl chr 9:21,073,005...21,124,544 		JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific decreases activity
multiple interactions		 ISO
EXP		 Roflumilast results in decreased activity of PDE4B protein
Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of PDE4B protein alternative form]
Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of PDE4B protein alternative form]		 CTD PMID:15901792 PMID:39197814 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456 		JBrowse link
G Pde4c phosphodiesterase 4C, cAMP specific decreases activity ISO Roflumilast results in decreased activity of PDE4C protein CTD PMID:15901792 NCBI chr 8:71,176,485...71,203,835
Ensembl chr 8:71,176,369...71,203,835 		JBrowse link
G Pde4d phosphodiesterase 4D, cAMP specific decreases activity ISO Roflumilast results in decreased activity of PDE4D protein CTD PMID:15901792 NCBI chr13:108,790,711...110,092,503
Ensembl chr13:108,586,482...110,089,995 		JBrowse link
G Pde7a phosphodiesterase 7A decreases activity ISO Roflumilast results in decreased activity of PDE7A protein CTD PMID:15901792 NCBI chr 3:19,277,272...19,365,486
Ensembl chr 3:19,277,272...19,365,486 		JBrowse link
G Pde8b phosphodiesterase 8B decreases activity ISO Roflumilast results in decreased activity of PDE8B protein CTD PMID:15901792 NCBI chr13:95,160,962...95,386,904
Ensembl chr13:95,160,962...95,386,844 		JBrowse link
G Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in decreased expression of PPM1A protein] CTD PMID:39197814 NCBI chr12:72,804,231...72,846,593
Ensembl chr12:72,804,229...72,846,593 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma multiple interactions ISO Roflumilast inhibits the reaction [Rotenone results in increased expression of PPP1CC protein] CTD PMID:36706892 NCBI chr 5:122,296,338...122,313,336
Ensembl chr 5:122,296,341...122,313,336 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B multiple interactions ISO Roflumilast inhibits the reaction [Rotenone results in decreased phosphorylation of PPP1R1B protein] CTD PMID:36706892 NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622 		JBrowse link
G Prkaca protein kinase, cAMP dependent, catalytic, alpha multiple interactions ISO Roflumilast inhibits the reaction [Rotenone results in decreased expression of PRKACA protein] CTD PMID:36706892 NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072 		JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 multiple interactions
increases expression		 ISO RAPGEF3 mutant form inhibits the reaction [Roflumilast results in increased phosphorylation of AKT1 protein]
Roflumilast results in increased expression of RAPGEF3 protein		 CTD PMID:18276108 NCBI chr15:97,637,886...97,666,300
Ensembl chr15:97,642,651...97,665,853 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
decreases expression		 ISO Cisplatin promotes the reaction [Roflumilast results in decreased expression of RELA mRNA]
Roflumilast inhibits the reaction [Cisplatin results in increased expression of RELA mRNA]; Roflumilast inhibits the reaction [Rotenone results in increased expression of RELA protein]		 CTD PMID:33757793 PMID:36706892 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein] CTD PMID:39197814 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO
EXP		 KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]
Roflumilast inhibits the reaction [Hypochlorous Acid results in increased phosphorylation of SMAD3 protein]		 CTD PMID:39197814 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Snca synuclein, alpha multiple interactions
increases degradation		 ISO Roflumilast inhibits the reaction [Rotenone results in increased expression of SNCA protein]
Roflumilast results in increased degradation of SNCA protein		 CTD PMID:37105514 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO		 Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of TGFB1 mRNA]
KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]]; KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]]; KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Roflumilast inhibits the reaction [TGFB1 protein results in decreased expression of PPM1A protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased activity of GLB1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CDKN1A protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CNN1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of FAP protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of PDE4B protein alternative form]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]		 CTD PMID:39197814 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Roflumilast inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Roflumilast inhibits the reaction [Rotenone results in increased expression of TNF protein]		 CTD PMID:21913898 PMID:33757793 PMID:36706892 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22327
    role 22313
      application 21950
        anti-asthmatic agent 9342
          anti-asthmatic drug 8766
            roflumilast 52
Path 2
Term Annotations click to browse term
  CHEBI ontology 22327
    subatomic particle 22322
      composite particle 22322
        hadron 22322
          baryon 22322
            nucleon 22322
              atomic nucleus 22322
                atom 22322
                  main group element atom 22209
                    p-block element atom 22209
                      carbon group element atom 22015
                        carbon atom 21958
                          organic molecular entity 21958
                            heteroorganic entity 21604
                              organochalcogen compound 21109
                                organooxygen compound 20946
                                  carbon oxoacid 19736
                                    carboxylic acid 19732
                                      carboacyl group 18298
                                        univalent carboacyl group 18298
                                          carbamoyl group 18112
                                            carboxamide 18112
                                              monocarboxylic acid amide 15891
                                                arenecarboxamide 8301
                                                  benzamides 8301
                                                    roflumilast 52
paths to the root