Esr1 (estrogen receptor 1) - Rat Genome Database

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Gene: Esr1 (estrogen receptor 1) Rattus norvegicus
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Symbol: Esr1
Name: estrogen receptor 1
RGD ID: 2581
Description: Enables several functions, including phosphatidylinositol 3-kinase regulatory subunit binding activity; promoter-specific chromatin binding activity; and transcription coactivator binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of signal transduction; and reproductive structure development. Located in several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study several diseases, including Parkinsonism; infertility; obesity; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1); PARTICIPATES IN estrogen signaling pathway; insulin-like growth factor signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-terminally-truncated estrogen receptor alpha product-1; Er alpha; ER-alpha; Esr; estradiol receptor; estrogen receptor; estrogen receptor 1 (alpha); Estrogen receptor alpha; estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha i45aL; estrogen receptor alpha i45aS; estrogen receptor alpha i45c; estrogen receptor alpha i56a; estrogen receptor alpha i56b; estrogen receptor alpha i56c; estrogen receptor alpha i56dL; estrogen receptor alpha i56dS; estrogen receptor alpha i56e; estrogen receptor alpha variant delta 4; nuclear receptor subfamily 3 group A member 1; RNESTROR; truncated estrogen receptor product-2; trunctaed estrogen receptor product-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Esr1em1Soar   Esr1em1Bra  
Genetic Models: SD-Esr1em1Bra-/- ACI.SD-Esr1em1Soar SD-Esr1em1Soar
Is Marker For: Strains:   SD  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8143,511,685 - 43,904,454 (+)NCBIGRCr8
mRatBN7.2141,106,335 - 41,499,104 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,210,475 - 41,495,002 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx141,764,020 - 42,022,224 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,751,203 - 48,009,419 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,839,517 - 42,097,729 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0141,192,029 - 41,594,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,192,824 - 41,594,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,534,049 - 42,935,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4135,523,680 - 35,759,891 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1135,526,624 - 35,762,826NCBI
Celera136,921,417 - 37,175,762 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (ISO)
arteriosclerosis  (ISO)
arthrogryposis multiplex congenita-3  (ISO)
atherosclerosis  (ISO)
autosomal dominant Emery-Dreifuss muscular dystrophy 4  (ISO)
autosomal recessive spinocerebellar ataxia 8  (ISO)
bone disease  (ISO)
Bone Fractures  (ISO)
breast cancer  (ISO,ISS)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
carcinoma  (ISO)
cataract 33  (ISO)
cerebellar ataxia  (ISO)
chromosome 6q24-q25 deletion syndrome  (ISO)
Chronic Periodontitis  (ISO)
coronary artery disease  (ISO)
cryptorchidism  (IEP)
Diabetic Nephropathies  (IEP,ISO)
Disease Progression  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
Estrogen Resistance  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IEP,ISO)
Female Infertility  (ISO)
Female Urogenital Diseases  (ISO)
Feminization  (ISO)
Genetic Predisposition to Disease  (ISO)
glomerulonephritis  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (IMP)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
in situ carcinoma  (ISO)
infertility  (IMP)
Knee Osteoarthritis  (ISO)
leiomyoma  (ISO)
leukemia  (ISO)
Leydig cell tumor  (ISO)
Liver Neoplasms  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphangioleiomyomatosis  (ISO)
macular degeneration  (ISO)
male infertility  (ISO)
malignant astrocytoma  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
Metabolic Bone Diseases  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
migraine  (ISO)
mitochondrial metabolism disease  (ISO)
Musculoskeletal Pain  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IMP)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
Neoplastic Cell Transformation  (ISO)
neuroblastoma  (ISO)
obesity  (IDA,ISO)
oligospermia  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Hip  (ISO)
osteoporosis  (IEP,ISO)
Osteoporotic Fractures  (IEP,ISO)
ovarian cancer  (IEP)
Parkinsonism  (IDA)
peritonitis  (IDA)
pleurisy  (IMP)
Postmenopausal Osteoporosis  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (IDA,ISO)
prostatic hypertrophy  (IMP)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
Spinal Cord Injuries  (IEP)
Spinal Fractures  (ISO)
sporadic breast cancer  (ISO)
Subarachnoid Hemorrhage  (IEP)
substance-induced psychosis  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (IDA)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Urination Disorders  (IDA)
Varicose Ulcer  (ISO)
vitiligo  (ISO)
Vulvar Lichen Sclerosus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-bursehernin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(3-phenoxyphenyl)methanol  (ISO)
(E)-thiamethoxam  (ISO)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
(R)-salsolinol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichlorobenzene  (ISO)
1,4-dichlorobenzene  (ISO)
1,4-dithiothreitol  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-Amino-2,4-dibromoanthraquinone  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-Hydroxypyrene  (ISO)
10H-phenothiazine  (ISO)
16alpha-Bromo-17beta-estradiol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-estradiol 3-benzoate  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5'-Tetrabromodiphenyl ether  (ISO)
2,2'-Bisphenol F  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2':5',2''-terthiophene  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,5-trichlorophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,6-diisopropylnaphthalene  (ISO)
2,6-dimethylnaphthalene  (ISO)
2-acetamidofluorene  (EXP)
2-Amino-1,6-dimethylfuro[3,2-e]imidazo[4,5-b]pyridine  (ISO)
2-Aminoanthraquinone  (ISO)
2-benzyl-4-chlorophenol  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-hydroxyestrone  (ISO)
2-methoxyethanol  (EXP)
2-sec-butylphenol  (ISO)
2-tert-butylhydroquinone  (ISO)
2-tert-Butylphenol  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,3'-Dimethylbenzidine  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3,6-diaminoacridine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-iodoprop-2-yn-1-yl butylcarbamate  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-methylquinoline  (ISO)
3-phenoxybenzoic acid  (EXP,ISO)
4'-epidoxorubicin  (ISO)
4'-hydroxydiclofenac  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,4'-thiodiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-Acetyl-6-tert-butyl-1,1-dimethylindane  (ISO)
4-chloro-3,5-dimethylphenol  (ISO)
4-ethylphenol  (ISO)
4-hexylbenzene-1,3-diol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-Hydroxyazobenzene  (EXP)
4-Hydroxybenzophenone  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Hydroxytestosterone  (ISO)
4-methylquinoline  (ISO)
4-nitrophenol  (EXP)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (EXP,ISO)
4-Propylphenol  (EXP,ISO)
4-terpineol  (ISO)
4-tert-Butylcyclohexyl acetate  (ISO)
4-tert-butylphenol  (EXP,ISO)
4-tert-Octylphenol  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
6-methylquinoline  (ISO)
6-oxocampestanol  (ISO)
6-prenylnaringenin  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8-methylquinoline  (ISO)
9-cis-retinoic acid  (EXP,ISO)
9-phenanthrol  (ISO)
acetamide  (EXP)
acetochlor  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alachlor  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldicarb  (ISO)
aldrin  (ISO)
alizarin  (ISO)
all-trans-phytoene  (ISO)
all-trans-phytofluene  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alpha-hexachlorocyclohexane  (EXP,ISO)
alpha-mangostin  (ISO)
alpha-Methylstyrene  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-terpineol  (ISO)
alpha-Zearalanol  (EXP,ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amsacrine  (ISO)
androgen antagonist  (EXP)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3beta,17beta-diol  (ISO)
androstane-3,17-diol  (ISO)
anethole  (EXP,ISO)
anilines  (ISO)
anthracene  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
artesunate  (ISO)
atrazine  (EXP,ISO)
avobenzone  (ISO)
azadirachtin A  (ISO)
azinphos-methyl  (ISO)
Azoxymethane  (ISO)
baicalein  (ISO)
bazedoxifene  (ISO)
bendiocarb  (ISO)
benidipine  (ISO)
benomyl  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzo[d]isothiazol-3-one  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
benzoates  (ISO)
benzophenone  (ISO)
benzophenones  (EXP)
benzothiophene  (ISO)
Benzoyl peroxide  (EXP)
benzyl benzoate  (ISO)
Benzyl parahydroxybenzoate  (ISO)
Benzyl salicylate  (ISO)
berberine  (ISO)
beryllium atom  (EXP)
beryllium dihydride  (EXP)
beryllium(0)  (EXP)
beta-carotene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-tocopherol  (EXP)
beta-Zearalanol  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
biochanin A  (EXP,ISO)
biphenyl  (ISO)
biphenyl-2-ol  (ISO)
biphenyl-4,4'-diol  (ISO)
biphenyl-4-ol  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol A dimethacrylate  (ISO)
Bisphenol A glycidylmethacrylate  (ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (EXP,ISO)
bisphenol F  (EXP,ISO)
bisphenol F diglycidyl ether  (ISO)
Bisphenol Z  (ISO)
bortezomib  (ISO)
brassinolide  (ISO)
bromocriptine  (ISO)
bromoethane  (ISO)
Bromofos  (ISO)
Bromophos-ethyl  (ISO)
bromuconazole  (ISO)
bucladesine  (EXP)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium dihydroxide  (ISO)
camphor  (ISO)
camptothecin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbendazim  (EXP,ISO)
carbon nanotube  (ISO)
carfilzomib  (ISO)
cedrol  (ISO)
chloramphenicol  (ISO)
chlordecone  (ISO)
chlormidazole  (ISO)
chlornitrofen  (ISO)
chlorobenzenes  (ISO)
Chlorobenzilate  (ISO)
chlorogenic acid  (EXP)
chlorohydrocarbon  (ISO)
chloropropylate  (ISO)
chlorpyrifos  (EXP,ISO)
chlorpyrifos-methyl  (ISO)
chromium(6+)  (EXP)
chrysene  (ISO)
chrysin  (ISO)
Ciclesonide  (ISO)
ciclopirox  (ISO)
ciguatoxin CTX1B  (ISO)
cilnidipine  (ISO)
cisplatin  (ISO)
citral  (ISO)
clofibrate  (EXP)
clomiphene  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
conjugated linoleic acid  (ISO)
copper(II) chloride  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
coumaphos  (ISO)
coumarins  (ISO)
coumestrol  (EXP,ISO)
curcumin  (ISO)
cyanazine  (ISO)
Cyanofenphos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cycloprothrin  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (EXP,ISO)
cyhalothrin  (EXP,ISO)
cypermethrin  (EXP,ISO)
cyprodinil  (EXP,ISO)
cyproterone acetate  (ISO)
D-aspartic acid  (EXP)
D-glucose  (EXP,ISO)
daidzein  (EXP,ISO)
danazol  (ISO)
daunorubicin  (ISO)
DDD  (ISO)
DDE  (EXP,ISO)
DDT  (EXP,ISO)
dehydroepiandrosterone  (ISO)
deisopropylatrazine  (ISO)
delta-hexachlorocyclohexane  (ISO)
delta-tocopherol  (EXP)
Deoxymiroestrol  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
diazinon  (ISO)
Dibenzo[a,h]pyrene  (ISO)
dibenzothiophene  (ISO)
dibenzoylmethane  (ISO)
dibromoacetic acid  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (ISO)
dichloromethane  (ISO)
dichlorvos  (ISO)
diclofenac  (ISO)
dicofol  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (EXP,ISO)
dienestrol  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
diheptyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethoate  (ISO)
dimethomorph  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
diniconazole  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (ISO)
Diphenolic acid  (ISO)
diphenylmethanol  (ISO)
dipropyl phthalate  (ISO)
diquat  (ISO)
disodium selenite  (EXP)
disulfiram  (ISO)
Dithiopyr  (ISO)
diuron  (ISO)
dobutamine  (ISO)
dodecylamine  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
EHT 1864  (ISO)
elemental selenium  (EXP)
emamectin benzoate  (EXP)
emetine  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
endrin  (ISO)
enilconazole  (ISO)
enzacamene  (EXP,ISO)
EPN  (ISO)
epoxiconazole  (ISO)
equilin  (EXP,ISO)
equol  (EXP,ISO)
erlotinib hydrochloride  (ISO)
Estradiol dipropionate  (ISO)
estriol  (EXP,ISO)
estrogen  (EXP)
estrone  (EXP,ISO)
Ethalfluralin  (ISO)
ethanol  (EXP,ISO)
ethion  (ISO)
ethisterone  (ISO)
Ethyl cinnamate  (ISO)
ethyl myristate  (ISO)
ethylenediaminetetraacetic acid  (ISO)
Ethylenethiourea  (ISO)
ethylparaben  (EXP,ISO)
etofenprox  (EXP)
etoposide  (ISO)
eugenol  (ISO)
exemestane  (ISO)
farrerol  (EXP)
felodipine  (ISO)
fenamiphos  (ISO)
fenarimol  (ISO)
fenbuconazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
fenvalerate  (EXP,ISO)
finasteride  (EXP,ISO)
fingolimod hydrochloride  (ISO)
fipronil  (EXP,ISO)
flavonoids  (ISO)
fluazifop-butyl  (ISO)
flucythrinate  (ISO)
fludioxonil  (ISO)
flumethrin  (ISO)
Flumetralin  (ISO)
fluoranthene  (EXP,ISO)
fluoxastrobin  (ISO)
flutamide  (EXP,ISO)
flutolanil  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
formestane  (ISO)
formononetin  (ISO)
fructose  (EXP)
fulvestrant  (EXP,ISO)
furan  (ISO)
Fusarielin A  (ISO)
galangin  (EXP)
galaxolide  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (EXP)
gefitinib  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
Geniposidic acid  (EXP)
genistein  (EXP,ISO)
geranial  (ISO)
geraniol  (ISO)
gestodene  (ISO)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glyceollin  (ISO)
glycitein  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
gonadorelin  (ISO)
Goserelin  (ISO)
heptachlor  (EXP,ISO)
Heptachlor epoxide  (ISO)
herbicide  (EXP,ISO)
hexachlorobenzene  (EXP,ISO)
hexachlorophene  (ISO)
hexestrol  (ISO)
hydralazine  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
hydrogencarbonate  (ISO)
hydroquinone  (ISO)
hydroxyflutamide  (ISO)
ibuprofen  (ISO)
icariside II  (ISO)
Icaritin  (ISO)
ICI-164384  (ISO)
idarubicin  (ISO)
imidacloprid  (ISO)
imidazoles  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP,ISO)
indoles  (ISO)
inulin  (ISO)
iodoacetic acid  (ISO)
ipriflavone  (ISO)
iprodione  (ISO)
Isobutylparaben  (EXP,ISO)
isofenphos  (ISO)
isoflavones  (EXP,ISO)
Isopropylparaben  (EXP,ISO)
isoprothiolane  (ISO)
isorhamnetin  (ISO)
Isoxanthohumol  (ISO)
ivermectin  (ISO)
kaempferol  (EXP,ISO)
ketoconazole  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP)
lacidipine  (ISO)
lapatinib  (ISO)
Laurolactam  (ISO)
lead(II) chloride  (ISO)
leptomycin B  (ISO)
leptophos  (ISO)
lercanidipine  (ISO)
letrozole  (ISO)
levonorgestrel  (ISO)
lidocaine  (ISO)
lignin  (EXP)
linalool  (ISO)
linalyl acetate  (ISO)
linuron  (EXP,ISO)
lipopolysaccharide  (ISO)
liquiritigenin  (ISO)
liraglutide  (ISO)
lithium chloride  (ISO)
loratadine  (ISO)
luteolin  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY 117018  (ISO)
LY294002  (ISO)
lycopene  (ISO)
Lynestrenol  (ISO)
M1  (ISO)
malathion  (ISO)
mancozeb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (ISO)
manidipine  (ISO)
masoprocol  (ISO)
medroxyprogesterone acetate  (ISO)
megestrol acetate  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
Melengestrol acetate  (ISO)
menadione  (ISO)
mepanipyrim  (EXP)
mercaptopurine  (EXP)
mercury dichloride  (ISO)
mestranol  (ISO)
metconazole  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methanol  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methiocarb  (ISO)
methomyl  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (EXP,ISO)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (ISO)
methyl laurate  (ISO)
methyl oleate  (ISO)
Methyl palmitate  (EXP,ISO)
methyl salicylate  (ISO)
methylarsonic acid  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (EXP,ISO)
metoclopramide  (ISO)
metolachlor  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
mirex  (ISO)
mithramycin  (ISO)
Mitotane  (EXP,ISO)
MK 571  (ISO)
MK-2206  (ISO)
molibresib  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
Moxestrol  (ISO)
mycophenolic acid  (ISO)
N,N'-diphenyl-1,4-phenylenediamine  (EXP)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-Desmethyltamoxifen  (ISO)
N-hydroxy-PhIP  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
n-propyl gallate  (ISO)
Nafoxidine  (ISO)
nandrolone  (ISO)
Nandrolone decanoate  (EXP)
naphthalene  (ISO)
napropamide  (ISO)
naringin  (EXP)
nebivolol  (ISO)
nicardipine  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nifedipine  (ISO)
nilotinib  (ISO)
nilutamide  (ISO)
nisoldipine  (ISO)
nitrazepam  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
nitroprusside  (ISO)
Nonylphenol  (EXP,ISO)
norethisterone  (EXP,ISO)
Norethynodrel  (ISO)
norgestrel  (EXP,ISO)
notoginsenoside R1  (EXP,ISO)
O-Desmethylangolensin  (ISO)
octadecanoic acid  (ISO)
octamethylcyclotetrasiloxane  (ISO)
octocrylene  (ISO)
okadaic acid  (ISO)
ormeloxifene  (EXP)
oryzalin  (ISO)
ospemifene  (ISO)
Oxadiazon  (ISO)
oxamyl  (ISO)
oxidopamine  (EXP)
oxybenzone  (EXP,ISO)
oxymetholone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP)
parathion  (ISO)
parathion-methyl  (ISO)
pendimethalin  (ISO)
pentachlorophenol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP,ISO)
phenanthrene  (ISO)
Phenethyl salicylate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenolphthalein  (ISO)
phenols  (ISO)
phenothrin  (ISO)
phenthoate  (ISO)
phenyl salicylate  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosalone  (ISO)
phoxim  (ISO)
phthalic acid  (ISO)
phytoestrogen  (EXP,ISO)
picene  (ISO)
picrotoxinin  (ISO)
piperonyl butoxide  (EXP)
Pirarubicin  (ISO)
pirfenidone  (ISO)
pirimicarb  (ISO)
pirimiphos-methyl  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium atom  (ISO)
potassium dichromate  (EXP)
potassium iodide  (EXP)
prallethrin  (ISO)
pregnenolone  (ISO)
procaine  (ISO)
prochloraz  (ISO)
prochlorperazine  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propamocarb  (ISO)
propanil  (ISO)
propargite  (ISO)
propham  (EXP)
propiconazole  (ISO)
propoxur  (ISO)
propylparaben  (EXP,ISO)
propyzamide  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (EXP)
prothiofos  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
purine-6-thiol  (EXP)
pyrazoles  (ISO)
pyrene  (ISO)
pyridaben  (ISO)
Pyridate  (ISO)
pyrimethanil  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quinaldine  (ISO)
quinalphos  (ISO)
quinizarin  (ISO)
quinolin-4-ol  (ISO)
quinolin-6-ol  (ISO)
quinoline  (ISO)
quinoline yellow  (ISO)
ractopamine  (ISO)
radicicol  (ISO)
raloxifene  (EXP,ISO)
resmethrin  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rhapontigenin  (ISO)
ritonavir  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
royal jelly  (ISO)
RU 58668  (ISO)
rubitecan  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
salicylates  (ISO)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
Selamectin  (ISO)
selenium atom  (EXP)
semicarbazide  (ISO)
silibinin  (EXP,ISO)
simazine  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (ISO)
sodium fluoride  (EXP)
sophoraflavanone B  (EXP,ISO)
Sophoricoside  (ISO)
staurosporine  (ISO)
stigmasterol  (ISO)
stilben-4-ol  (ISO)
stilbene-4,4'-diol  (ISO)
streptozocin  (EXP,ISO)
styrenes  (ISO)
succimer  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
superoxide  (ISO)
Swertiamarin  (EXP)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
tartrazine  (ISO)
tea tree oil  (ISO)
tebuconazole  (ISO)
tegaserod  (ISO)
Temsirolimus  (ISO)
teniposide  (ISO)
terbufos  (ISO)
terbutylazine  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
Testosterone propionate  (EXP,ISO)
Tetrachlorobisphenol A  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetrachlorvinphos  (ISO)
tetradifon  (ISO)
tetrahydropalmatine  (EXP,ISO)
tetralin  (ISO)
tetramethrin  (EXP)
tetraphene  (EXP,ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
tibolone  (ISO)
tin(II) chloride (anhydrous)  (ISO)
tiratricol  (ISO)
titanium dioxide  (ISO)
tolclofos-methyl  (ISO)
topotecan  (ISO)
toremifene  (ISO)
toxaphene  (EXP,ISO)
TRAM-34  (ISO)
trans-anethole  (EXP,ISO)
trans-stilbene-4,4'-diol  (ISO)
trenbolone  (ISO)
Tri-2-ethylhexyl trimellitate  (ISO)
triadimefon  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclocarban  (ISO)
triclosan  (EXP,ISO)
trifloxystrobin  (ISO)
trifluralin  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triphenylethylene  (ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
Tris(2-ethylhexyl) phosphate  (ISO)
triticonazole  (ISO)
trovafloxacin  (ISO)
tyrphostin AG 1478  (ISO)
Urolithin A  (ISO)
valinomycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP,ISO)
vincristine  (ISO)
vinyl carbamate  (ISO)
vitamin E  (EXP)
vorinostat  (ISO)
wortmannin  (EXP)
xanthohumol  (ISO)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen metabolic process  (IEA,ISO)
antral ovarian follicle growth  (IEA,ISO)
baculum development  (IEP)
cellular response to estradiol stimulus  (IDA,IEA,ISO)
cellular response to estrogen stimulus  (IBA,IEA,IEP,ISO)
cellular response to wortmannin  (IEP)
decidualization  (IEP)
epithelial cell development  (IEA,ISO)
epithelial cell proliferation involved in mammary gland duct elongation  (IEA,ISO)
estrogen receptor signaling pathway  (IBA,IEA,ISO)
fibroblast proliferation  (IEA,ISO)
male gonad development  (IEA,IEP,ISO)
mammary gland alveolus development  (IEA,ISO)
mammary gland branching involved in pregnancy  (IEA,ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO,ISS)
negative regulation of D-glucose import  (IDA)
negative regulation of DNA-binding transcription factor activity  (ISO,ISS)
negative regulation of gene expression  (IEA,ISO)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of smooth muscle cell apoptotic process  (IMP)
negative regulation of smooth muscle cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of triglyceride metabolic process  (IDA)
nuclear receptor-mediated steroid hormone signaling pathway  (IDA,IEA)
osteoblast development  (IEP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of DNA-binding transcription factor activity  (ISO,ISS)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of epidermal growth factor receptor signaling pathway  (IMP)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (ISO,ISS)
positive regulation of nitric-oxide synthase activity  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,TAS)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (IEA,ISO)
prostate epithelial cord elongation  (IEA,ISO)
protein localization to chromatin  (IEA,ISO)
regulation of branching involved in prostate gland morphogenesis  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of epithelial cell apoptotic process  (IEA,ISO)
regulation of inflammatory response  (IEA,ISO)
regulation of toll-like receptor signaling pathway  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to estradiol  (IEP,ISO)
response to estrogen  (ISO)
RNA polymerase II preinitiation complex assembly  (IEA,ISO)
Sertoli cell development  (IEP)
Sertoli cell proliferation  (IMP)
stem cell differentiation  (IEA,ISO)
steroid hormone receptor signaling pathway  (ISO)
transcription by RNA polymerase II  (ISO)
uterus development  (IEA,ISO)
vagina development  (IEA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutational and polymorphic analysis of the estradiol receptor-alpha gene in men with symptomatic vertebral fractures. Allcroft LC, etal., Calcif Tissue Int. 2002 Nov;71(5):400-5. Epub 2002 Aug 19.
2. The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells. Alyea RA, etal., J Neurochem. 2008 Aug;106(4):1525-33. Epub 2008 May 19.
3. The promoter C specific ERalpha isoform is associated with tamoxifen outcome in breast cancer. Amaral S, etal., Breast Cancer Res Treat. 2009 Nov;118(2):323-31. doi: 10.1007/s10549-008-0241-9. Epub 2008 Nov 15.
4. The dinucleotide (CA) repeat polymorphism of estrogen receptor beta but not the dinucleotide (TA) repeat polymorphism of estrogen receptor alpha is associated with venous ulceration. Ashworth JJ, etal., J Steroid Biochem Mol Biol. 2005 Nov;97(3):266-70. Epub 2005 Sep 8.
5. Opposing roles of ERalpha and ERbeta in the genesis and progression of adenocarcinoma in the rat ventral prostate. Attia DM and Ederveen AG, Prostate. 2012 Jun 15;72(9):1013-22. doi: 10.1002/pros.21507. Epub 2011 Oct 24.
6. Breast cancer, estrogen receptor and ligands. Bai Z and Gust R, Arch Pharm (Weinheim). 2009 Mar;342(3):133-49.
7. The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease. Baraka AM, etal., Life Sci. 2011 May 9;88(19-20):879-85. doi: 10.1016/j.lfs.2011.03.010. Epub 2011 Mar 21.
8. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
9. Aberrant CpG island methylation of the p16(INK4a) and estrogen receptor genes in rat lung tumors induced by particulate carcinogens. Belinsky SA, etal., Carcinogenesis 2002 Feb;23(2):335-9.
10. Association of estrogen receptor alpha gene polymorphisms and lifestyle factors with calcaneal quantitative ultrasound and osteoporosis in postmenopausal Vietnamese women. Binh TQ, etal., J Hum Genet. 2006;51(11):1022-9. Epub 2006 Sep 14.
11. Estrogen receptor-alpha is developmentally regulated during osteoblast differentiation and contributes to selective responsiveness of gene expression. Bodine PV, etal., Endocrinology. 1998 Apr;139(4):2048-57.
12. Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder. Boekhoorn SS, etal., Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1012-7.
13. Preliminary evidence for impaired estrogen receptor-alpha protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis. Braidman I, etal., Bone. 2000 May;26(5):423-7.
14. Association of the estrogen receptor alpha gene polymorphisms with sporadic Alzheimer's disease. Brandi ML, etal., Biochem Biophys Res Commun 1999 Nov 19;265(2):335-8.
15. Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor. Carpino A, etal., Eur J Endocrinol. 2007 Aug;157(2):239-44.
16. Colocalization and hormone regulation of estrogen receptor alpha and N-methyl-D-aspartate receptor in the hypothalamus of female rats. Chakraborty TR, etal., Endocrinology 2003 Jan;144(1):299-305.
17. Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells. Chen YJ, etal., Endocrinology. 2008 Sep;149(9):4658-68. Epub 2008 May 29.
18. Effects of agonists for estrogen receptor alpha and beta on ovariectomy-induced lower urinary tract dysfunction in the rat. Cheng CL and de Groat WC, Am J Physiol Renal Physiol. 2014 Jan;306(2):F181-7. doi: 10.1152/ajprenal.00298.2013. Epub 2013 Nov 20.
19. Callus formation is related to the expression ratios of estrogen receptors-alpha and -beta in ovariectomy-induced osteoporotic fracture healing. Chow SK, etal., Arch Orthop Trauma Surg. 2014 Oct;134(10):1405-16. doi: 10.1007/s00402-014-2070-0. Epub 2014 Aug 2.
20. Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk. Colin EM, etal., J Clin Endocrinol Metab. 2003 Aug;88(8):3777-84.
21. Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation. Conway K, etal., Breast Cancer Res. 2007;9(3):R36.
22. Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoids. Cuzzocrea S, etal., Mol Pharmacol. 2007 Jan;71(1):132-44. Epub 2006 Oct 11.
23. Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose. Dahlman I, etal., Pharmacogenet Genomics. 2008 Nov;18(11):967-75.
24. Association of single nucleotide polymorphisms in estrogen receptor alpha gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population. Dai X, etal., Biomed Res Int. 2014;2014:151457. doi: 10.1155/2014/151457. Epub 2014 Mar 17.
25. Expression of estrogen receptor co-regulators SRC-1, RIP140 and NCoR and their interaction with estrogen receptor in rat uterus, under the influence of ormeloxifene. Daverey A, etal., J Steroid Biochem Mol Biol. 2009 Aug;116(1-2):93-101. Epub 2009 May 19.
26. An estrogen receptor repressor induces cataract formation in transgenic mice. Davis VL, etal., Proc Natl Acad Sci U S A 2002 Jul 9;99(14):9427-32. Epub 2002 Jun 24.
27. Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Day JK, etal., Nutr Cancer. 2001;39(2):226-32.
28. Estrogen receptor expression in cutaneous melanoma: a real-time reverse transcriptase-polymerase chain reaction and immunohistochemical study. de Giorgi V, etal., Arch Dermatol. 2009 Jan;145(1):30-6. doi: 10.1001/archdermatol.2008.537.
29. Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes. Delfosse V, etal., Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14930-5. doi: 10.1073/pnas.1203574109. Epub 2012 Aug 27.
30. Estrogen receptor 1 polymorphisms are associated with airway hyperresponsiveness and lung function decline, particularly in female subjects with asthma. Dijkstra A, etal., J Allergy Clin Immunol. 2006 Mar;117(3):604-11. Epub 2006 Feb 15.
31. 17beta-estradiol-mediated neuroprotection and ERK activation require a pertussis toxin-sensitive mechanism involving GRK2 and beta-arrestin-1. Dominguez R, etal., J Neurosci. 2009 Apr 1;29(13):4228-38.
32. Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats. Doucet D, etal., PLoS One. 2010 Feb 25;5(2):e9421.
33. Amelioration of collagen-induced arthritis and immune-associated bone loss through signaling via estrogen receptor alpha, and not estrogen receptor beta or G protein-coupled receptor 30. Engdahl C, etal., Arthritis Rheum. 2010 Feb;62(2):524-33. doi: 10.1002/art.25055.
34. The activating enzyme of NEDD8 inhibits steroid receptor function. Fan M, etal., Mol Endocrinol 2002 Feb;16(2):315-30.
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PMID:19094096   PMID:19121391   PMID:19176323   PMID:19211896   PMID:19220308   PMID:19309532   PMID:19420389   PMID:19429457   PMID:19460862   PMID:19470835   PMID:19500225   PMID:19523531  
PMID:19525133   PMID:19671997   PMID:19694624   PMID:19698287   PMID:19703497   PMID:19726745   PMID:19797124   PMID:19818101   PMID:19833204   PMID:19887773   PMID:19889994   PMID:19948032  
PMID:19953342   PMID:20005806   PMID:20043825   PMID:20064538   PMID:20068009   PMID:20074560   PMID:20080953   PMID:20085801   PMID:20096765   PMID:20132863   PMID:20136685   PMID:20136693  
PMID:20160663   PMID:20196785   PMID:20237133   PMID:20298751   PMID:20347696   PMID:20388878   PMID:20419096   PMID:20424134   PMID:20479872   PMID:20497523   PMID:20554652   PMID:20584107  
PMID:20702577   PMID:20807534   PMID:20881113   PMID:20887556   PMID:20926584   PMID:20930192   PMID:20954080   PMID:20969598   PMID:21029595   PMID:21119048   PMID:21127968   PMID:21131358  
PMID:21166214   PMID:21182205   PMID:21186342   PMID:21192956   PMID:21304949   PMID:21311134   PMID:21484804   PMID:21486807   PMID:21530561   PMID:21536991   PMID:21642474   PMID:21695196  
PMID:21747171   PMID:21774811   PMID:21849544   PMID:21937726   PMID:21972199   PMID:21981076   PMID:21984253   PMID:21995903   PMID:22033279   PMID:22064478   PMID:22080140   PMID:22093896  
PMID:22152882   PMID:22169964   PMID:22192617   PMID:22230296   PMID:22295098   PMID:22321458   PMID:22354782   PMID:22521344   PMID:22541803   PMID:22562172   PMID:22659029   PMID:22659940  
PMID:22713467   PMID:22791648   PMID:22809666   PMID:22843122   PMID:22844453   PMID:22853951   PMID:22962310   PMID:23020785   PMID:23034157   PMID:23065768   PMID:23077105   PMID:23123743  
PMID:23183182   PMID:23209733   PMID:23288162   PMID:23300088   PMID:23414238   PMID:23515288   PMID:23543101   PMID:23610132   PMID:23701824   PMID:23748073   PMID:23749762   PMID:23911387  
PMID:23984641   PMID:24070737   PMID:24188094   PMID:24292258   PMID:24303535   PMID:24332041   PMID:24378445   PMID:24495337   PMID:24518793   PMID:24629021   PMID:24823389   PMID:25010766  
PMID:25051443   PMID:25211590   PMID:25213639   PMID:25217305   PMID:25256868   PMID:25451981   PMID:25486578   PMID:25612677   PMID:25655704   PMID:25738436   PMID:25813982   PMID:25864222  
PMID:25869617   PMID:26018677   PMID:26062878   PMID:26069273   PMID:26151894   PMID:26314929   PMID:26371374   PMID:26408543   PMID:26923515   PMID:26987957   PMID:27004961   PMID:27080432  
PMID:27254005   PMID:27256361   PMID:27473146   PMID:27499186   PMID:27594441   PMID:27603028   PMID:27698063   PMID:28068668   PMID:28283583   PMID:28353029   PMID:28412386   PMID:28559116  
PMID:28789814   PMID:29030963   PMID:29121167   PMID:29568895   PMID:29777335   PMID:30400032   PMID:30447247   PMID:30790128   PMID:30822411   PMID:30974146   PMID:31050077   PMID:31081962  
PMID:31115535   PMID:31250245   PMID:31527615   PMID:31804540   PMID:31917318   PMID:31926947   PMID:31931041   PMID:31968225   PMID:32580515   PMID:32593544   PMID:32632943   PMID:32781251  
PMID:33064565   PMID:33322656   PMID:34125331   PMID:34416391   PMID:35594890   PMID:35698449   PMID:36746131   PMID:36879072   PMID:37595756   PMID:37914358   PMID:38029582   PMID:38713613  
PMID:39138001  


Genomics

Comparative Map Data
Esr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8143,511,685 - 43,904,454 (+)NCBIGRCr8
mRatBN7.2141,106,335 - 41,499,104 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,210,475 - 41,495,002 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx141,764,020 - 42,022,224 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,751,203 - 48,009,419 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,839,517 - 42,097,729 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0141,192,029 - 41,594,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,192,824 - 41,594,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,534,049 - 42,935,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4135,523,680 - 35,759,891 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1135,526,624 - 35,762,826NCBI
Celera136,921,417 - 37,175,762 (+)NCBICelera
Cytogenetic Map1q11NCBI
ESR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386151,656,672 - 152,129,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6151,656,691 - 152,129,619 (+)EnsemblGRCh38hg38GRCh38
GRCh376151,977,807 - 152,450,754 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366152,170,379 - 152,466,099 (+)NCBINCBI36Build 36hg18NCBI36
Build 346152,220,799 - 152,516,520NCBI
Celera6152,745,469 - 153,158,143 (+)NCBICelera
Cytogenetic Map6q25.1-q25.2NCBI
HuRef6149,573,851 - 149,986,188 (+)NCBIHuRef
CHM1_16152,275,698 - 152,688,511 (+)NCBICHM1_1
T2T-CHM13v2.06152,857,871 - 153,330,911 (+)NCBIT2T-CHM13v2.0
Esr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39104,561,989 - 4,955,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl104,561,593 - 4,955,614 (+)EnsemblGRCm39 Ensembl
GRCm38104,611,989 - 5,005,633 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl104,611,593 - 5,005,614 (+)EnsemblGRCm38mm10GRCm38
MGSCv37105,342,780 - 5,734,495 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36105,342,780 - 5,734,495 (-)NCBIMGSCv36mm8
Celera104,553,702 - 4,949,051 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.03NCBI
Esr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554399,588,201 - 9,963,353 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554399,588,631 - 9,953,606 (-)NCBIChiLan1.0ChiLan1.0
ESR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25171,714,055 - 172,130,308 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16169,722,942 - 170,016,810 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06149,507,599 - 149,918,523 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16154,200,521 - 154,635,806 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6154,317,002 - 154,631,551 (+)Ensemblpanpan1.1panPan2
ESR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1142,081,952 - 42,368,544 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl142,081,969 - 42,368,544 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,923,315 - 43,207,109 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0142,267,417 - 42,551,842 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl142,267,396 - 42,570,184 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1142,140,418 - 42,417,150 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0141,990,600 - 42,280,338 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0142,491,321 - 42,775,607 (+)NCBIUU_Cfam_GSD_1.0
Esr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946137,259,082 - 137,635,196 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364894,614,754 - 4,887,171 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364894,616,839 - 4,887,179 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl114,217,036 - 14,493,363 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1114,217,032 - 14,604,906 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2116,546,666 - 16,577,163 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ESR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11379,153,418 - 79,554,552 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1379,270,265 - 79,554,549 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604051,453,078 - 51,888,098 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Esr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247856,164,379 - 6,601,326 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247856,164,507 - 6,601,302 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Esr1
1293 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:153
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000026350
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat

Markers in Region
RH94746  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2141,239,034 - 41,239,135 (+)MAPPERmRatBN7.2
Rnor_6.0141,325,496 - 41,325,596NCBIRnor6.0
Rnor_5.0142,669,477 - 42,669,577UniSTSRnor5.0
RGSC_v3.4135,525,972 - 35,526,072UniSTSRGSC3.4
Celera136,923,709 - 36,923,809UniSTS
Cytogenetic Map1q12UniSTS
AU047540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2141,377,679 - 41,377,888 (+)MAPPERmRatBN7.2
Rnor_6.0141,467,377 - 41,467,585NCBIRnor6.0
Rnor_5.0142,807,788 - 42,807,996UniSTSRnor5.0
RGSC_v3.4135,672,192 - 35,672,400UniSTSRGSC3.4
Celera137,058,320 - 37,058,528UniSTS
Cytogenetic Map1q12UniSTS


Related Rat Strains
The following Strains have been annotated to Esr1
SD     W    


Genetic Models
This gene Esr1 is modified in the following models/strains:
SD-Esr1em1Bra-/-     ACI.SD-Esr1em1Soar     SD-Esr1em1Soar    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 37 95 67 66 35 25 35 6 182 85 75 45 57 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001433730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB477027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB477030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB477032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB477036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB477037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB477038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB477039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB738827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB738828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB738829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB738830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB738831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB738832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB738833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF169237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU111761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ746832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ746833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L38930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC260503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC260504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC260505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC260506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC260507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X98236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X98237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000026350   ⟹   ENSRNOP00000026350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,236,742 - 41,495,002 (+)Ensembl
Rnor_6.0 Ensembl141,323,194 - 41,590,697 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078494   ⟹   ENSRNOP00000071400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,236,742 - 41,495,002 (+)Ensembl
Rnor_6.0 Ensembl141,325,531 - 41,590,619 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081017   ⟹   ENSRNOP00000072170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,238,999 - 41,456,710 (+)Ensembl
Rnor_6.0 Ensembl141,325,462 - 41,594,796 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082133   ⟹   ENSRNOP00000071981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,238,999 - 41,436,307 (+)Ensembl
Rnor_6.0 Ensembl141,192,824 - 41,325,726 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088168   ⟹   ENSRNOP00000071034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,236,742 - 41,495,002 (+)Ensembl
Rnor_6.0 Ensembl141,325,531 - 41,590,619 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl141,323,240 - 41,323,885 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089984   ⟹   ENSRNOP00000070339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl141,590,494 - 41,592,204 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098680   ⟹   ENSRNOP00000096866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,238,999 - 41,436,307 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111868   ⟹   ENSRNOP00000097043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,238,999 - 41,462,415 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112253   ⟹   ENSRNOP00000086873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,238,999 - 41,440,317 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114176   ⟹   ENSRNOP00000094314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,210,475 - 41,463,618 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117998   ⟹   ENSRNOP00000081498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,238,999 - 41,461,907 (+)Ensembl
RefSeq Acc Id: NM_012689   ⟹   NP_036821
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,642,095 - 43,900,354 (+)NCBI
mRatBN7.2141,236,742 - 41,495,002 (+)NCBI
Rnor_6.0141,323,204 - 41,590,697 (+)NCBI
Rnor_5.0142,534,049 - 42,935,434 (+)NCBI
RGSC_v3.4135,523,680 - 35,759,891 (+)RGD
Celera136,921,417 - 37,175,762 (+)RGD
Sequence:
RefSeq Acc Id: XM_006227832   ⟹   XP_006227894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,597,836 - 43,904,454 (+)NCBI
mRatBN7.2141,192,062 - 41,499,104 (+)NCBI
Rnor_6.0141,278,645 - 41,590,623 (+)NCBI
Rnor_5.0142,534,049 - 42,935,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008758704   ⟹   XP_008756926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,616,139 - 43,904,454 (+)NCBI
mRatBN7.2141,236,933 - 41,499,104 (+)NCBI
Rnor_6.0141,320,411 - 41,590,623 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588795   ⟹   XP_017444284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,511,702 - 43,904,454 (+)NCBI
mRatBN7.2141,106,342 - 41,499,104 (+)NCBI
Rnor_6.0141,192,029 - 41,590,623 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588796   ⟹   XP_017444285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,665,427 - 43,904,454 (+)NCBI
mRatBN7.2141,239,560 - 41,499,104 (+)NCBI
Rnor_6.0141,336,017 - 41,590,619 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588797   ⟹   XP_017444286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,511,690 - 43,904,454 (+)NCBI
mRatBN7.2141,106,336 - 41,499,104 (+)NCBI
Rnor_6.0141,325,460 - 41,594,799 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101029   ⟹   XP_038956957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,511,701 - 43,904,454 (+)NCBI
mRatBN7.2141,106,342 - 41,499,104 (+)NCBI
RefSeq Acc Id: XM_039101033   ⟹   XP_038956961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,511,699 - 43,904,454 (+)NCBI
mRatBN7.2141,106,341 - 41,499,104 (+)NCBI
RefSeq Acc Id: XM_039101049   ⟹   XP_038956977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,511,685 - 43,864,244 (+)NCBI
mRatBN7.2141,106,335 - 41,458,872 (+)NCBI
RefSeq Acc Id: XM_039101051   ⟹   XP_038956979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,511,690 - 43,869,946 (+)NCBI
mRatBN7.2141,106,337 - 41,465,318 (+)NCBI
RefSeq Acc Id: XM_063281065   ⟹   XP_063137135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,616,139 - 43,904,454 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001420659 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420660 (Get FASTA)   NCBI Sequence Viewer  
  NP_036821 (Get FASTA)   NCBI Sequence Viewer  
  XP_006227894 (Get FASTA)   NCBI Sequence Viewer  
  XP_008756926 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444284 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444285 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444286 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956957 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956961 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956977 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956979 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137135 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADK56112 (Get FASTA)   NCBI Sequence Viewer  
  AIE17715 (Get FASTA)   NCBI Sequence Viewer  
  AIE17716 (Get FASTA)   NCBI Sequence Viewer  
  BAI48013 (Get FASTA)   NCBI Sequence Viewer  
  BAX25512 (Get FASTA)   NCBI Sequence Viewer  
  BAX25513 (Get FASTA)   NCBI Sequence Viewer  
  BAX25514 (Get FASTA)   NCBI Sequence Viewer  
  BAX25515 (Get FASTA)   NCBI Sequence Viewer  
  BAX25516 (Get FASTA)   NCBI Sequence Viewer  
  BAX25517 (Get FASTA)   NCBI Sequence Viewer  
  BAX25518 (Get FASTA)   NCBI Sequence Viewer  
  BAX30169 (Get FASTA)   NCBI Sequence Viewer  
  BAX30170 (Get FASTA)   NCBI Sequence Viewer  
  BAX30171 (Get FASTA)   NCBI Sequence Viewer  
  BAX30172 (Get FASTA)   NCBI Sequence Viewer  
  BAX30173 (Get FASTA)   NCBI Sequence Viewer  
  CAA43411 (Get FASTA)   NCBI Sequence Viewer  
  CAA66888 (Get FASTA)   NCBI Sequence Viewer  
  CAA68287 (Get FASTA)   NCBI Sequence Viewer  
  EDL92853 (Get FASTA)   NCBI Sequence Viewer  
  EDL92854 (Get FASTA)   NCBI Sequence Viewer  
  EDL92855 (Get FASTA)   NCBI Sequence Viewer  
  EDL92857 (Get FASTA)   NCBI Sequence Viewer  
  EDL92858 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026350.7
  ENSRNOP00000071034.1
  ENSRNOP00000071400.1
  ENSRNOP00000071981.2
  ENSRNOP00000072170.2
  ENSRNOP00000081498.1
  ENSRNOP00000086873.1
  ENSRNOP00000094314.1
  ENSRNOP00000096866.1
  ENSRNOP00000097043.1
GenBank Protein P06211 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036821   ⟸   NM_012689
- UniProtKB: P06211 (UniProtKB/Swiss-Prot),   A0A9K3Y766 (UniProtKB/TrEMBL),   D0FYH4 (UniProtKB/TrEMBL),   F1M839 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227894   ⟸   XM_006227832
- Peptide Label: isoform X2
- UniProtKB: P06211 (UniProtKB/Swiss-Prot),   D0FYH4 (UniProtKB/TrEMBL),   F1M839 (UniProtKB/TrEMBL),   A0A9K3Y766 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008756926   ⟸   XM_008758704
- Peptide Label: isoform X2
- UniProtKB: P06211 (UniProtKB/Swiss-Prot),   D0FYH4 (UniProtKB/TrEMBL),   F1M839 (UniProtKB/TrEMBL),   A0A9K3Y766 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444284   ⟸   XM_017588795
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017444286   ⟸   XM_017588797
- Peptide Label: isoform X6
- UniProtKB: A0A0G2K0D4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444285   ⟸   XM_017588796
- Peptide Label: isoform X5
- Sequence:
Ensembl Acc Id: ENSRNOP00000071981   ⟸   ENSRNOT00000082133
Ensembl Acc Id: ENSRNOP00000070339   ⟸   ENSRNOT00000089984
Ensembl Acc Id: ENSRNOP00000026350   ⟸   ENSRNOT00000026350
Ensembl Acc Id: ENSRNOP00000071400   ⟸   ENSRNOT00000078494
Ensembl Acc Id: ENSRNOP00000072170   ⟸   ENSRNOT00000081017
Ensembl Acc Id: ENSRNOP00000071034   ⟸   ENSRNOT00000088168
RefSeq Acc Id: XP_038956977   ⟸   XM_039101049
- Peptide Label: isoform X3
- UniProtKB: A0A1W7GYV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956979   ⟸   XM_039101051
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AKJ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956961   ⟸   XM_039101033
- Peptide Label: isoform X1
- UniProtKB: P06211 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038956957   ⟸   XM_039101029
- Peptide Label: isoform X1
- UniProtKB: P06211 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000096866   ⟸   ENSRNOT00000098680
Ensembl Acc Id: ENSRNOP00000086873   ⟸   ENSRNOT00000112253
Ensembl Acc Id: ENSRNOP00000094314   ⟸   ENSRNOT00000114176
Ensembl Acc Id: ENSRNOP00000081498   ⟸   ENSRNOT00000117998
Ensembl Acc Id: ENSRNOP00000097043   ⟸   ENSRNOT00000111868
RefSeq Acc Id: XP_063137135   ⟸   XM_063281065
- Peptide Label: isoform X2
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06211-F1-model_v2 AlphaFold P06211 1-600 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2581 AgrOrtholog
BioCyc Gene G2FUF-61714 BioCyc
Ensembl Genes ENSRNOG00000019358 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026350.8 UniProtKB/TrEMBL
  ENSRNOT00000078494.2 UniProtKB/TrEMBL
  ENSRNOT00000081017.2 UniProtKB/TrEMBL
  ENSRNOT00000082133.2 UniProtKB/TrEMBL
  ENSRNOT00000088168.2 UniProtKB/TrEMBL
  ENSRNOT00000098680.1 UniProtKB/TrEMBL
  ENSRNOT00000111868.1 UniProtKB/TrEMBL
  ENSRNOT00000112253.1 UniProtKB/TrEMBL
  ENSRNOT00000114176.1 UniProtKB/TrEMBL
  ENSRNOT00000117998.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Estr_rcpt_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hormone_rcpt_NR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oest_rcpt/oest-rel_rcp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oestr_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oestrogen-typ_rcpt_final_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24890 UniProtKB/Swiss-Prot
NCBI Gene 24890 ENTREZGENE
PANTHER ESTROGEN RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KNIRPS-RELATED PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ESR1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oest_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ESR1 RGD
PhenoGen Esr1 PhenoGen
PIRSF ER-a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ER-like_NR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS OESTROGENR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019358 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A068JFJ9_RAT UniProtKB/TrEMBL
  A0A068JIX3_RAT UniProtKB/TrEMBL
  A0A0G2JZG2_RAT UniProtKB/TrEMBL
  A0A0G2K0D4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K1T9_RAT UniProtKB/TrEMBL
  A0A1W7GKK8_RAT UniProtKB/TrEMBL
  A0A1W7GKK9_RAT UniProtKB/TrEMBL
  A0A1W7GKL1_RAT UniProtKB/TrEMBL
  A0A1W7GKL5_RAT UniProtKB/TrEMBL
  A0A1W7GKL6_RAT UniProtKB/TrEMBL
  A0A1W7GYU9_RAT UniProtKB/TrEMBL
  A0A1W7GYV1 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W7GYV2_RAT UniProtKB/TrEMBL
  A0A1W7GYV5_RAT UniProtKB/TrEMBL
  A0A1W7GYV7_RAT UniProtKB/TrEMBL
  A0A8I6AKJ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y766 ENTREZGENE, UniProtKB/TrEMBL
  A6KIM0_RAT UniProtKB/TrEMBL
  D0FYH4 ENTREZGENE, UniProtKB/TrEMBL
  ESR1_RAT UniProtKB/Swiss-Prot
  F1M839 ENTREZGENE
  P06211 ENTREZGENE
UniProt Secondary A0A1W7GKL0 UniProtKB/TrEMBL
  F1M839 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Esr1  estrogen receptor 1  Esr1  estrogen receptor 1 (alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Esr1  estrogen receptor 1 (alpha)  Esr1  estrogen receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Esr1  estrogen receptor 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs administration of the antiestrogen ICI 182,780 (a steroidal antiestrogen that binds to both ER-a and ER-b and does not cross the blood-brain barrier) decreases mRNA and protein of Slc9a3 628385
gene_expression abundant in myocytes secreting atrial natriuretic peptide (ANP) 69504
gene_expression abundantly expressed in atria but not in the ventricles of adults 69504
gene_expression developmentally regulated in the rat heart 69504
gene_expression expressed in middle-aged animals by norepinephrine (NE) and epinephrine neurons 628385
gene_expression expressed in cerebral blood vessels, smooth muscle and endothelium 628385
gene_function binds to estrogen and serves as transcriptional coactivator for estrogen-sensitive genes 69504
gene_function binds to estrogen and serves as transcriptional coactivator for estrogen-sensitive genes 628555
gene_process predominant estrogenic mediator in the heart 69504
gene_process predominant estrogenic mediator in the heart 628555
gene_process may play a role in heart maturation and myocardial regulation 69504
gene_process may play a role in heart maturation and myocardial regulation 628555
gene_process required for the expression and function of Slc9a3 (Na+-H+ exchanger-3) 628385
gene_protein multi-sized products of 110,93,82,66,50 and 45 kDa; may represent unique states or splice variants of the protein 628385
gene_regulation elevated expression in response to 17-beta estradiol treatment and in intact females 628385
gene_regulation may be activated by proteasomal degradation 628385