RGD Reference Report - Estrogen receptor gene polymorphisms are associated with recurrence of endometriosis. - Rat Genome Database

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Estrogen receptor gene polymorphisms are associated with recurrence of endometriosis.

Authors: Luisi, S  Galleri, L  Marini, F  Ambrosini, G  Brandi, ML  Petraglia, F 
Citation: Luisi S, etal., Fertil Steril. 2006 Mar;85(3):764-6.
RGD ID: 1580337
Pubmed: PMID:16500359   (View Abstract at PubMed)
DOI: DOI:10.1016/j.fertnstert.2005.08.038   (Journal Full-text)

The presence of gene polymorphisms of the estrogen receptors ERalpha (PvuII and XbaI) and ERbeta (AluI) in 61 women with endometriosis was investigated. A statistically significant correlation between PvuII ERalpha gene polymorphism (PvuII), both in homozygosity (PP) and in heterozygosity (Pp), and a recurrence of endometriosis was found. In conclusion, women affected by endometriosis with the ERalpha polymorphic allele, even if heterozygous, have a worse prognosis, and these results suggest that the ERalpha gene polymorphisms may be included among the genetic risk factors for endometriosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endometriosis  IAGP 1580337 RGD 
endometriosis  ISOESR1 (Homo sapiens)1580337; 1580337 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Esr1  (estrogen receptor 1)

Genes (Mus musculus)
Esr1  (estrogen receptor 1 (alpha))

Genes (Homo sapiens)
ESR1  (estrogen receptor 1)


Additional Information