GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | fludioxonil results in decreased expression of ESR1 mRNA | PMID:23052036 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | fludioxonil results in increased activity of ESR1 protein | PMID:20143881 PMID:26812056 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [fludioxonil co-treated with Estradiol] results in decreased expression of ESR1 mRNA; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with Chlorpyrifos] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR1 protein; ESR1 protein affects the reaction [fludioxonil results in decreased expression of CCND1 mRNA]; fludioxonil binds to and results in increased activity of ESR1 protein; fludioxonil inhibits the reaction [Estradiol results in increased activity of ESR1 protein] | PMID:23052036 PMID:23436777 PMID:26812056 PMID:33049310 | |
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