RGD Reference Report - Breast cancer, estrogen receptor and ligands. - Rat Genome Database

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Breast cancer, estrogen receptor and ligands.

Authors: Bai, Z  Gust, R 
Citation: Bai Z and Gust R, Arch Pharm (Weinheim). 2009 Mar;342(3):133-49.
RGD ID: 4892064
Pubmed: PMID:19274700   (View Abstract at PubMed)
DOI: DOI:10.1002/ardp.200800174   (Journal Full-text)

This review emphasizes the relationship of breast cancer, estrogen receptor and ligands, especially the centrality of the estrogen receptor, which mediates on one hand the hormone-induced gene transcription and on the other hand the anti-estrogen action against breast cancer. The characterization of the estrogen receptor ligand-binding domain co-crystallized with agonists or antagonists provided a molecular basis to gain an insight into the regulation of estrogen receptor and, thereby, to describe the mechanism of the hormone therapy in treating breast cancer.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Esr1  (estrogen receptor 1)
Esr2  (estrogen receptor 2)
Gper1  (G protein-coupled estrogen receptor 1)

Genes (Mus musculus)
Esr1  (estrogen receptor 1 (alpha))
Esr2  (estrogen receptor 2 (beta))
Gper1  (G protein-coupled estrogen receptor 1)

Genes (Homo sapiens)
ESR1  (estrogen receptor 1)
ESR2  (estrogen receptor 2)
GPER1  (G protein-coupled estrogen receptor 1)


Additional Information