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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:132813
Term: quinaldine
Definition: A quinoline compound in which the quinoline skeleton is substituted at C-2 with a methyl group.
Chemical ID: MESH:C037073
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases activityISOESR1 (Homo sapiens)6480464CTD2-methylquinoline analog results in increased activity of ESR1 proteinPMID:30896932
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD2-methylquinoline analog inhibits the reaction [Estradiol binds to ESR1 protein]; 2-methylquinoline inhibits the reaction [Estradiol binds to ESR1 protein]PMID:30896932
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