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Strain Registration

Strain: SD

Symbol: SD
Strain: SD
Full Name: Sprague-Dawley
RGD ID: 70508
Citation ID: RRID:RGD_70508
Ontology ID: RS:0000681
Alleles: Aqp1;   E2f1;   Brca2;   Crebbp;   Cyp11b1;   Drd1;   Edn1;   Esr1;   Gabrb1;   Htr1b;   Nos1;   Nppa;   Nppb;   Prlr;   Sdc1;   Sdc4;   Gpc1;   Alox15;   E2f5;   Slc15a1;   Cnga1;   Brca1
Type: outbred
Available Source: Not Available
Description: This strain was initiated by R. Dawley, Sprague-Dawley Company, Madison, Wisconsin in 1925. A hybrid hooded male of unknown origin was mated to a white female (Douredoure strain, probably Wistar) and subsequently to his white female offspring for 7 generations. All the current colonies are from this original stock.
Coat Color: albino
Last Known Status: Unknown

Substrains
SD/A
SD/HsdCwr
SD/Rij





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
mean arterial blood pressure
body weight
heart weight
red blood cell count
blood hemoglobin level
platelet count
hematocrit
red blood cell distribution width-coefficient of variation
blood glucose level
blood urea nitrogen level
blood total cholesterol level
plasma total protein level
serum creatinine level
plasma potassium level
heart wet weight
heart weight to body weight ratio
left kidney wet weight
both kidneys wet weight
lung weight
blood triglyceride level
blood bilirubin level
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
adrenal gland weight
brain wet weight
liver wet weight
both lungs wet weight
adrenal gland wet weight
spleen wet weight
testis wet weight
ejection fraction
timed urine volume
left atrium weight
right atrium weight
blood differential white blood cell count
food intake rate
glomerular filtration rate
blood potassium level
blood sodium level
blood calcium level
blood phosphate level
heart left ventricle weight to body weight ratio
blood creatinine level
blood albumin level
plasma aldosterone level
serum testosterone level
plasma angiotensin II level
blood alanine aminotransferase activity level
blood alkaline phosphatase activity level
blood aspartate aminotransferase activity level
plasma urea nitrogen level
left ventricular end-systolic blood pressure
left ventricular end-diastolic blood pressure
urine total protein excretion rate
urine protein excretion rate
urine sodium excretion rate
creatinine clearance
heart left ventricle weight
heart right ventricle weight
heart right ventricle weight to body weight ratio
amount of experiment time spent in a discrete space in an experimental apparatus
number of entries into a discrete space in an experimental apparatus
heart left ventricle end-diastolic diameter
heart left ventricle end-systolic diameter
heart left ventricle fractional shortening
plasma epinephrine level
plasma norepinephrine level
creatinine clearance to body weight ratio
kidney sclerotic glomeruli count to total glomeruli count ratio
total horizontal distance resulting from voluntary locomotion in an experimental apparatus
serum total immunoglobulin E level
maximum rate of positive change in left ventricular blood pressure
maximum rate of negative change in left ventricular blood pressure
renal plasma flow
effective renal plasma flow
change in body weight
serum immunoglobulin E level
duration of loss of righting reflex
blood globulin level
blood albumin level to blood globulin level ratio
uterus wet weight
heart left ventricle end-diastolic posterior wall thickness
time to locate a hidden target platform in an experimental apparatus
percentage of study population developing anorectal malformation during a period of time
anogenital distance to cube root of body weight ratio
urine protein level to urine creatinine level ratio
renal plasma flow to body weight ratio
glomerular filtration rate to body weight ratio
blood hemoglobin A1c level
renal filtration fraction
heart left atrium weight to body weight ratio
heart right atrium weight to body weight ratio
heart septum weight
serum parathyroid hormone level
plasma angiotensin I level
serum interleukin-4 level
serum interleukin-9 level
intestine trypsin level
plasma nifedipine level
the first 120min of plasma nifedipine level area under curve
plasma nifedipine level area under curve
nifedipine mean residence time
plasma nifedipine clearance
verapamil apparent influx permeability clearance in retina
verapamil apparent influx permeability clearance in aqueous humor
verapamil equilibrated distribution volume in retina
verapamil equilibrated distribution volume in aqueous humor
brain uptake index of verapamil
retinal uptake index of verapamil
aqueous humor uptake index of verapamil
aqueous humor uptake index of digoxin
brain uptake index of digoxin
retinal uptake index of digoxin
aqueous humor uptake index of quinidine
brain uptake index of quinidine
retinal uptake index of quinidine
left ventricle end-diastolic wall stress
left ventricle end-systolic wall stress
plasma bradykinin level
heart left ventricle infarction area to total heart left ventricle area ratio
ratio of the area occupied by interstitial collagen to the total area of the heart left ventricle
heart left ventricle end-diastolic diameter to posterior wall thickness ratio
heart left ventricle interstitial bradykinin level during a period of time
heart left ventricle interstitial angiotensin II level during a period of time
heart left ventricle interstitial epinephrine level during a period of time
heart left ventricle interstitial norepinephrine level during a period of time

References

References - curated
# Reference Title Reference Citation
1. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Bhat KP, etal., Cancer Res 2001 Oct 15;61(20):7456-63.
2. Chronic intravenous administration of V1 arginine vasopressin agonist results in sustained hypertension. Cowley AW Jr, etal., Am J Physiol 1994 Aug;267(2 Pt 2):H751-6.
3. Spectral analysis of arterial pressure lability in rats with sinoaortic deafferentation. Jacob HJ, etal., Am J Physiol 1995 Dec;269(6 Pt 2):R1481-8.
4. Increased renal medullary H2O2 leads to hypertension. Makino A, etal., Hypertension 2003 Jul;42(1):25-30. Epub 2003 Jun 02.
5. Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats. Ogihara T, etal., Diabetes 2001 Mar;50(3):573-83.
6. Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway. Pap M and Cooper GM, Mol Cell Biol 2002 Jan;22(2):578-86.
7. RGD Strain RSO annotation pipeline RGD Automated Pipelines
8. Newly Developed Rat Model of Chronic Kidney Disease-Mineral Bone Disorder. Watanabe K, etal., J Atheroscler Thromb. 2017 Jul 1. doi: 10.5551/jat.40170.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Grows very slowly and attains a significant low body weight. 628526
strain_drgs_chems Trans-3,4,5-trihydroxystilbene (resveratrol) a phytoalexin is a potential chemopreventive agent for breast cancer. This inhibits the formation of estrogen-dependent preneoplastic ductal lesions and reduces N-methyl-N-nitrourea-induced tumergenesis. 628526
strain_drgs_chems Decreased insulin sensitivity induced with a high-salt diet was not reversed by administration of pioglitazone. 68927
strain_drgs_chems In streptozotocin (STZ)-treated diabetic rats serotonin content increases in enterochromaffin cells but not in serotonin-containing neurons 70606
strain_drgs_chems SD rats when infused with V1 arginine vasopressin agonist for 14 days, resulted in sustained elevated arterial pressure. 1303375
strain_drgs_chems Medullary infusion of TEMPOL and DETC results in increase of mean arterial pressure. 1303387
strain_drgs_chems Increased arterial pressure is observed when H2O2 is directly infused into the renal medulla. 1303387
strain_phys_biochem High salt (8% NaCl)- fed SD rats developed slightly higher systolic blood pressure, hyperglycemic, hyperinsulinemic than controls, with no change in food intake or body weight. Despite the presence of insulin resistance, high salt- fed rats showed enhanced insulin-induced tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1), IRS-2 (liver and muscle), and IRS-3 (liver only). 68927