GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | decreases expression | ISO | Esr1 (Mus musculus) | 6480464 | CTD | SB 203580 results in decreased expression of ESR1 protein | PMID:19340542 | Esr1 | multiple interactions | ISO | Esr1 (Mus musculus) | 6480464 | CTD | SB 203580 inhibits the reaction [Estradiol results in increased expression of ESR1 protein] | PMID:19340542 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [SB 203580 co-treated with naringenin] results in increased degradation of ESR1 protein; SB 203580 inhibits the reaction [[ESR1 protein results in increased susceptibility to Quercetin] which results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[ESR1 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein]; SB 203580 promotes the reaction [Estradiol results in increased degradation of ESR1 protein] | PMID:19194971 PMID:24586459 | | ||||||||||||||||||||||
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