GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | multiple interactions | EXP | | 6480464 | CTD | [1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole results in decreased activity of ESR1 protein] which results in increased susceptibility to bisphenol S | PMID:25723814 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | bisphenol S binds to ESR1 protein | PMID:30143207 | Esr1 | decreases expression | ISO | Esr1 (Mus musculus) | 6480464 | CTD | bisphenol S results in decreased expression of ESR1 mRNA; bisphenol S results in decreased expression of ESR1 protein | PMID:29526645 PMID:36310694 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | bisphenol S results in decreased expression of ESR1 mRNA; bisphenol S results in decreased expression of ESR1 protein | PMID:31995776 PMID:34831106 PMID:37224786 | Esr1 | increases acetylation | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | bisphenol S results in increased acetylation of ESR1 protein | PMID:37315367 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | bisphenol S metabolite results in increased activity of ESR1 protein; bisphenol S results in increased activity of ESR1 protein | PMID:23714657 PMID:27213244 PMID:30582956 PMID:35077665 PMID:36534918 | Esr1 | increases expression | ISO | Esr1 (Mus musculus) | 6480464 | CTD | bisphenol S results in increased expression of ESR1 mRNA | PMID:30196065 PMID:31245508 | Esr1 | increases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | bisphenol S results in increased expression of ESR1 protein | PMID:36565802 | Esr1 | increases phosphorylation | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | bisphenol S results in increased phosphorylation of ESR1 protein | PMID:32105160 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of ESR1 protein; [KDM2A protein co-treated with bisphenol S] results in increased acetylation of ESR1 protein; [KDM2A protein co-treated with bisphenol S] results in increased phosphorylation of and results in decreased methylation of ESR1 protein; bisphenol S binds to and results in increased activity of ESR1 protein; bisphenol S inhibits the reaction [ESR1 protein binds to BLOC1S1 protein]; bisphenol S inhibits the reaction [ESR1 protein binds to CHD9 protein]; bisphenol S inhibits the reaction [ESR1 protein binds to CNOT1 protein]; bisphenol S inhibits the reaction [ESR1 protein binds to CREBBP protein]; bisphenol S inhibits the reaction [ESR1 protein binds to DHX30 protein]; bisphenol S inhibits the reaction [ESR1 protein binds to GNAQ protein]; bisphenol S inhibits the reaction [ESR1 protein binds to GSN protein]; bisphenol S inhibits the reaction [ESR1 protein binds to HELZ2 protein]; bisphenol S inhibits the reaction [ESR1 protein binds to HR protein]; bisphenol S inhibits the reaction [ESR1 protein binds to MGMT protein]; bisphenol S inhibits the reaction [ESR1 protein binds to NCOR1 protein]; bisphenol S inhibits the reaction [ESR1 protein binds to NCOR2 protein]; bisphenol S inhibits the reaction [ESR1 protein binds to NELFB protein]; bisphenol S inhibits the reaction [ESR1 protein binds to PAK6 protein]; bisphenol S inhibits the reaction [ESR1 protein binds to PELP1 protein]; bisphenol S inhibits the reaction [ESR1 protein binds to PPRC1 protein]; bisphenol S inhibits the reaction [ESR1 protein binds to PRAME protein]; bisphenol S inhibits the reaction [ESR1 protein binds to PRDM2 protein]; bisphenol S inhibits the reaction [ESR1 protein binds to PROX1 protein]; bisphenol S inhibits the reaction [ESR1 protein binds to RAD9A protein]; bisphenol S inhibits the reaction [ESR1 protein binds to TGFB1I1 protein]; bisphenol S promotes the reaction [ESR1 protein binds to DNMT1 promoter]; bisphenol S promotes the reaction [ESR1 protein binds to DNMT3B promoter]; bisphenol S promotes the reaction [ESR1 protein binds to JMJD1C protein]; bisphenol S promotes the reaction [ESR1 protein binds to KAT5 protein]; bisphenol S promotes the reaction [ESR1 protein binds to KDM2A protein]; bisphenol S promotes the reaction [ESR1 protein binds to LCOR protein]; bisphenol S promotes the reaction [ESR1 protein binds to MED1 protein]; bisphenol S promotes the reaction [ESR1 protein binds to NCOA1 protein]; bisphenol S promotes the reaction [ESR1 protein binds to NCOA2 protein]; bisphenol S promotes the reaction [ESR1 protein binds to NCOA3 protein]; bisphenol S promotes the reaction [ESR1 protein binds to NR0B1 protein]; bisphenol S promotes the reaction [ESR1 protein binds to NR0B2 protein]; bisphenol S promotes the reaction [ESR1 protein binds to NRIP1 protein]; bisphenol S promotes the reaction [ESR1 protein binds to PELP1 protein]; bisphenol S promotes the reaction [ESR1 protein binds to PPARGC1A protein]; bisphenol S promotes the reaction [ESR1 protein binds to PPARGC1B protein]; bisphenol S results in increased activity of [ESR1 protein co-treated with ESR2 protein]; bisphenol S results in increased phosphorylation of and results in decreased methylation of ESR1 protein; ESR1 protein affects the reaction [bisphenol S results in increased expression of KDM2A protein]; ESR1 protein promotes the reaction [bisphenol S results in decreased abundance of 5-hydroxymethylcytosine]; ESR1 protein promotes the reaction [bisphenol S results in decreased expression of TET2 mRNA]; ESR1 protein promotes the reaction [bisphenol S results in decreased expression of TET2 protein]; ESR1 protein promotes the reaction [bisphenol S results in increased expression of DNMT1 mRNA]; ESR1 protein promotes the reaction [bisphenol S results in increased expression of DNMT1 protein]; ESR1 protein promotes the reaction [bisphenol S results in increased expression of DNMT3B mRNA]; ESR1 protein promotes the reaction [bisphenol S results in increased expression of DNMT3B protein]; ESR1 protein promotes the reaction [bisphenol S results in increased methylation of TET2 promoter]; Fulvestrant inhibits the reaction [bisphenol S results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol S results in increased expression of ESR1 protein] | PMID:22507746 PMID:23562765 PMID:27633901 PMID:28591870 PMID:29389661 PMID:29392883 PMID:31388671 PMID:31995776 PMID:32105160 PMID:33049310 PMID:36565802 PMID:37315367 | | ||||||||||||||||||||||
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