Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:50207
Term: sophoraflavanone B
Definition: A trihydroxyflavanone that is (S)-naringenin having a prenyl group at position 8.
Chemical ID: MESH:C119737
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTD8-prenylnaringenin results in decreased expression of ESR1 proteinPMID:34848279
Esr1increases expressionEXP 6480464CTD8-prenylnaringenin results in increased expression of ESR1 mRNAPMID:34848279
Esr1multiple interactionsEXP 6480464CTD[Fulvestrant co-treated with 8-prenylnaringenin] results in increased expression of ESR1 mRNA; Fulvestrant inhibits the reaction [8-prenylnaringenin results in decreased expression of ESR1 protein]PMID:34848279
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTD8-prenylnaringenin results in decreased expression of ESR1 proteinPMID:32986415
Esr1increases activityISOESR1 (Homo sapiens)6480464CTD8-prenylnaringenin results in increased activity of ESR1 proteinPMID:12623674 PMID:17716812
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD8-prenylnaringenin analog binds to and results in increased activity of ESR1 protein; 8-prenylnaringenin binds to and results in increased activity of ESR1 protein; [8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [8-prenylnaringenin results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]PMID:12650720 PMID:15876408 PMID:16076101 PMID:17149865 PMID:32986415
Go Back to source page   Continue to Ontology report