GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | increases activity | EXP | | 6480464 | CTD | Estrone results in increased activity of ESR1 protein | PMID:11750080 | Esr1 | affects binding | ISO | Esr1 (Mus musculus) | 6480464 | CTD | Estrone binds to ESR1 protein | PMID:11162928 PMID:19913605 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Estrone binds to ESR1 protein | PMID:11162928 PMID:11518614 PMID:12598185 PMID:19233257 PMID:19913605 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Estrone results in increased activity of ESR1 protein | PMID:11331656 PMID:22562034 | Esr1 | increases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Estrone results in increased expression of ESR1 mRNA | PMID:29783106 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Estrone binds to and results in increased activity of ESR1 protein; Estrone inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Estrone inhibits the reaction [ESR1 results in increased susceptibility to Cisplatin]; Estrone inhibits the reaction [Estradiol binds to ESR1 protein]; Estrone promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; Estrone promotes the reaction [ESR1 protein binds to ESR1 protein]; Estrone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Estrone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]; Fulvestrant inhibits the reaction [Estrone results in increased activity of ESR1 protein] | PMID:12127041 PMID:12676605 PMID:18026938 PMID:19233257 PMID:21767602 PMID:22562034 PMID:23383871 PMID:25012808 PMID:26865669 PMID:29162470 PMID:33049310 PMID:9048584 | |
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