A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID:
MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Fulvestrant binds to and results in decreased activity of ESR1 protein]; [Fulvestrant co-treated with 8-prenylnaringenin] results in increased expression of ESR1 mRNA; [Fulvestrant co-treated with biochanin A] results in decreased expression of ESR1 protein; [Fulvestrant co-treated with biochanin A] results in increased expression of ESR1 mRNA; [Fulvestrant co-treated with Coumestrol] results in increased expression of ESR1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fulvestrant results in increased degradation of ESR1 protein]; Fulvestrant binds to and results in decreased activity of ESR1 protein; Fulvestrant inhibits the reaction [8-prenylnaringenin results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [[Ethinyl Estradiol co-treated with Triclosan] results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A affects the expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A affects the expression of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in decreased phosphorylation of and affects the localization of ESR1 protein]; Fulvestrant inhibits the reaction [butylparaben results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [butylparaben results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [Coumestrol results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to HSD3B gene]]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]; Fulvestrant inhibits the reaction [Glyphosate results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [naringin results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [tributyltin affects the expression of ESR1 protein]
Fulvestrant results in decreased expression of ESR1; Fulvestrant results in decreased expression of ESR1 mRNA; Fulvestrant results in decreased expression of ESR1 protein
4-tert-octylphenol inhibits the reaction [Fulvestrant results in increased expression of ESR1 mRNA]; [bisphenol A co-treated with Fulvestrant] results in increased expression of ESR1 mRNA; bisphenol A inhibits the reaction [Fulvestrant results in increased expression of ESR1 mRNA]; Estradiol inhibits the reaction [Fulvestrant results in increased expression of ESR1 mRNA]; Fulvestrant binds to and results in decreased activity of ESR1 protein; Fulvestrant binds to and results in increased activity of ESR1 protein mutant form; Fulvestrant inhibits the reaction [4-tert-octylphenol results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [[notoginsenoside R1 co-treated with Lipopolysaccharides] results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [cyhalothrin results in increased expression of ESR1]; Fulvestrant inhibits the reaction [Diarylheptanoids binds to and affects the transport of ESR1 protein]; Fulvestrant inhibits the reaction [Diethylstilbestrol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [dioscin results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]; Fulvestrant inhibits the reaction [Estradiol binds to and affects the transport of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Estrogens results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [octylphenol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [tributyltin results in decreased expression of ESR1 protein]; Fulvestrant promotes the reaction [bisphenol A results in decreased expression of ESR1 protein]; Fulvestrant promotes the reaction [Estradiol results in increased expression of ESR1 protein]
5-OH-BDE-47 promotes the reaction [Fulvestrant results in decreased expression of ESR1 protein]; 6-OH-BDE-47 promotes the reaction [Fulvestrant results in decreased expression of ESR1 protein]; [Estradiol co-treated with Fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [Fulvestrant binds to and results in decreased activity of ESR1 protein] inhibits the reaction [Drugs, Chinese Herbal results in increased activity of ESR1 protein]; [Fulvestrant binds to and results in decreased activity of ESR1 protein] inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; [Fulvestrant binds to and results in decreased activity of ESR1 protein] inhibits the reaction [icaritin results in increased activity of ESR1 protein]; [Fulvestrant binds to and results in decreased activity of ESR1 protein] inhibits the reaction [Quercetin results in increased activity of ESR1 protein]; [Fulvestrant binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Equol; [Fulvestrant binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Genistein; [Fulvestrant binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA; [Fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [Fulvestrant results in decreased expression of ESR1 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; AG 1879 inhibits the reaction [Fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fulvestrant results in decreased expression of ESR1 protein]; Cadmium inhibits the reaction [Fulvestrant results in increased expression of ESR1 mRNA]; Curcumin inhibits the reaction [Fulvestrant results in increased degradation of ESR1 protein]; Fulvestrant affects the folding of and affects the activity of ESR1 protein; Fulvestrant binds to and results in decreased activity of ESR1 protein; Fulvestrant inhibits the reaction [1,1-bis(4-hydroxyphenyl)cyclohexane results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Fulvestrant inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [4,4'-bisphenol F results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [4,4'-bisphenol F results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [4,4'-dihydroxystilbene analog binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of and results in increased phosphorylation of ESR1 protein]; Fulvestrant inhibits the reaction [4-hydroxystilbene analog binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [[6-(1,1-dimethylallyl)naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [[bisphenol A co-treated with ESR1 protein] results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [[Coumestrol binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased expression of NOS3 mRNA]; Fulvestrant inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [[Genistein binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Androstenols results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [benz(a)anthracene promotes the reaction [Estradiol results in increased activity of ESR1 protein]]; Fulvestrant inhibits the reaction [Benzo(a)pyrene promotes the reaction [Estradiol results in increased activity of ESR1 protein]]; Fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to CTSD promoter]]; Fulvestrant inhibits the reaction [bisphenol A results in decreased methylation of ESR1 gene]; Fulvestrant inhibits the reaction [bisphenol A results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol B results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol S results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol S results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [butylparaben results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [Coumestrol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Diarylheptanoids results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Diarylheptanoids results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Diethylstilbestrol binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Equilin results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [ESR1 protein binds to CDKN1A promoter]; Fulvestrant inhibits the reaction [ESR1 protein binds to STUB1 protein]; Fulvestrant inhibits the reaction [ESR1 protein results in increased susceptibility to Resveratrol]; Fulvestrant inhibits the reaction [Estradiol affects the localization of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Fulvestrant inhibits the reaction [Estriol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Estrone results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [fenarimol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [fluoranthene promotes the reaction [Estradiol results in increased activity of ESR1 protein]]; Fulvestrant inhibits the reaction [Genistein results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Glyphosate results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of ESR1 protein]]; Fulvestrant inhibits the reaction [Methylcholanthrene results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]]; Fulvestrant inhibits the reaction [o,p'-DDT results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [prochloraz results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Progesterone results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [propylparaben results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Resveratrol analog binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Resveratrol binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]; Fulvestrant inhibits the reaction [Tartrazine results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Testosterone results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; Fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to HSD3B gene]]]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]]; Fulvestrant inhibits the reaction [tri-(2-ethylhexyl)trimellitate metabolite results in increased activity of ESR1 protein]; Fulvestrant promotes the reaction [5-OH-BDE-47 affects the expression of ESR1 protein]; Fulvestrant promotes the reaction [6-OH-BDE-47 affects the expression of ESR1 protein]; Fulvestrant promotes the reaction [ESR1 protein binds to ESR1 protein]; Fulvestrant promotes the reaction [ESR1 protein binds to ESR2 protein]; Fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]; Fulvestrant promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; Fulvestrant promotes the reaction [Hexachlorobenzene results in decreased expression of ESR1 protein]; Fulvestrant results in decreased activity of and results in decreased expression of ESR1 protein; Fulvestrant results in increased degradation of and results in decreased expression of and results in decreased activity of ESR1 protein; KRT18 protein promotes the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]; KRT18 protein promotes the reaction [Fulvestrant results in increased degradation of ESR1 protein]; KRT8 protein promotes the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]; KRT8 protein promotes the reaction [Fulvestrant results in increased degradation of ESR1 protein]; RU 58668 promotes the reaction [Fulvestrant inhibits the reaction [Genistein results in increased activity of ESR1 protein]]; tyrphostin AG 1024 inhibits the reaction [Fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]]
