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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:28689
Term: dehydroepiandrosterone
Definition: An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Chemical ID: MESH:D003687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOEsr1 (Mus musculus)6480464CTDDehydroepiandrosterone binds to ESR1 proteinPMID:19913605
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDDehydroepiandrosterone binds to ESR1 proteinPMID:19913605
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDDehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form; Dehydroepiandrosterone results in increased expression of ESR1 protein alternative formPMID:25969534
Esr1increases phosphorylationISOESR1 (Homo sapiens)6480464CTDDehydroepiandrosterone results in increased phosphorylation of ESR1 proteinPMID:25969534
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDDehydroepiandrosterone binds to and results in increased activity of ESR1 protein; ESR1 protein alternative form promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form]PMID:15994348 PMID:25969534 PMID:33049310
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