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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTDMethylcholanthrene results in decreased expression of ESR1 mRNAPMID:29094188
Esr1increases expressionEXP 6480464CTDMethylcholanthrene results in increased expression of ESR1 mRNAPMID:23273579
Esr1multiple interactionsEXP 6480464CTDalpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ESR1 mRNA]PMID:29094188
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDMethylcholanthrene binds to ESR1 proteinPMID:16489053
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDMethylcholanthrene results in decreased expression of ESR1 mRNAPMID:20348232
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDMethylcholanthrene results in increased activity of ESR1 proteinPMID:16257430
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDMethylcholanthrene results in increased expression of ESR1 mRNAPMID:16489053
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [Methylcholanthrene results in increased expression of ESR1 mRNA]; Methylcholanthrene binds to and results in increased activity of ESR1 protein; Methylcholanthrene promotes the reaction [AHR protein binds to ESR1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to ESR1 promoter]; Methylcholanthrene promotes the reaction [ESR1 protein binds to CYP1A1 promoter]PMID:16489053 PMID:16972788 PMID:20348232
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