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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:4035
Term: cyhalothrin
Definition: A carboxylic ester obtained by formal condensation between 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol.
Chemical ID: MESH:C037304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases activityEXP 6480464CTDcyhalothrin results in increased activity of ESR1 proteinPMID:20410157
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDcyhalothrin results in decreased expression of ESR1 mRNA; cyhalothrin results in decreased expression of ESR1 proteinPMID:18419197 PMID:20097460
Esr1increases expressionISOEsr1 (Mus musculus)6480464CTDcyhalothrin results in increased expression of ESR1PMID:26969072
Esr1multiple interactionsISOEsr1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyhalothrin results in increased expression of ESR1]; fulvestrant inhibits the reaction [cyhalothrin results in increased expression of ESR1]PMID:26969072
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