BISPHENOL A RESPONSE PATHWAY (PW:0001511)

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Description

Bisphenols represent a large family of compounds used in the manufacture of various consumer products of which the most widely used is bisphenol A (BPA) - [2,2-bis(4-hydroxyphenyl)propane]. BPA is used in the production of many types of plastics, the lining of food containers, medical and dental devices, thermal paper. The high levels of BPA production underlie its presence in the environment. In addition, BPA can also be found in food due to its leaching out of containers. BPA is an endocrine

Pathway Diagram:

Elsevier Inc. Bisphenol A ---> thermal paper Bisphenol A ---> plastic wares Esr downstream effects Gper1 activation of growth factor signaling and downstream pathways reproductive/birth defects/developmental Esr1 Esr2 bisphenol A degradation pathway estrogen signaling pathway titanium dioxide nanoparticle response pathway anatase Bisphenol A BPA-adducts Bisphenol A ---- Gper1 Bisphenol A ---- Esr2 Bisphenol A ---> medical devices Bisphenol A --+> Esr2 Bisphenol A ---- Esr1 Bisphenol A --+> Esr1 Bisphenol A --+> Gper1 Bisphenol A ---> chromosomal aberrations bisphenol A degradation pathway ---| environmental contamination anatase ---> titanium dioxide nanoparticle response pathway DNA Damage medical devices thermal paper beverage/food cans plastic wares Bisphenol A ---> beverage/food cans photoelectrocatalysis photoelectrocatalysis ---| environmental contamination chromosomal aberrations Bisphenol A ---> BPA-adducts Bisphenol A ---> DNA Damage cardiovascular/kidney/respiratory Bisphenol A ---- cardiovascular/kidney/respiratory diabetes/obesity immunity/cancer food contamination environmental contamination
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Genes in Pathway:

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bisphenol A response pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:8547944
RGD:8548497
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:8547944
RGD:8548497
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:8547944
RGD:8548497

Pathway Gene Annotations

Disease Annotations Associated with Genes in the bisphenol A response pathway
Disease TermsGene Symbols
Abnormalities, MultipleGper1
AdenocarcinomaEsr1 , Esr2
AdenomaEsr2
AlopeciaEsr2
Alzheimer DiseaseEsr1 , Esr2
Anxiety DisordersEsr2
Aortic Valve StenosisEsr2
Arrhythmias, CardiacEsr2
ArteriosclerosisEsr1
Arthritis, ExperimentalEsr1 , Esr2
Arthritis, RheumatoidEsr2
AsthmaEsr2
AstrocytomaEsr1 , Esr2
AtherosclerosisEsr1 , Esr2
Blast CrisisEsr2
Bone Diseases, MetabolicEsr1
Brain IschemiaEsr2
Breast Cancer, FamilialEsr1
Breast NeoplasmsEsr1 , Esr2 , Gper1
Bronchial HyperreactivityEsr1
CarcinomaEsr1 , Esr2
Carcinoma in SituEsr1 , Esr2
Carcinoma, EndometrioidEsr1
Carcinoma, HepatocellularEsr1
Carcinoma, Non-Small-Cell LungEsr1
Carcinoma, Transitional CellEsr2
Cataract, Cortical, Juvenile-OnsetEsr1
Cell Transformation, NeoplasticEsr1
Chronic PeriodontitisEsr1
Cocaine-Related DisordersEsr2
Colonic NeoplasmsEsr2
Colorectal NeoplasmsEsr2
Coronary Artery DiseaseEsr1 , Esr2
Coronary DiseaseEsr2
Crohn DiseaseEsr2
CryptorchidismEsr1
CystitisEsr2
Cystitis, InterstitialEsr2
DeafnessEsr2
Depressive DisorderEsr2
Dermatitis, ContactEsr2
Diabetes Mellitus, ExperimentalEsr1
Diabetes Mellitus, Type 2Esr1
Diabetic NephropathiesEsr1
Disease Models, AnimalEsr1
Disease ProgressionEsr1
Encephalomyelitis, Autoimmune, ExperimentalEsr2
Endometrial NeoplasmsEsr1 , Esr2
EndometriosisEsr1 , Esr2
Estrogen ResistanceEsr1
Female Urogenital DiseasesEsr1
FeminizationEsr1
Fractures, BoneEsr1
Glaucoma, Primary Open AngleEsr2
GlomerulonephritisEsr1
GlomerulosclerosisEsr2
Graves DiseaseEsr2
Hashimoto DiseaseEsr2
Hearing LossEsr2
Hot FlashesEsr2
HyperalgesiaEsr1 , Esr2
HypertensionEsr2
Hypertension, PulmonaryEsr1 , Esr2
Hypertrophy, Left VentricularEsr2
HypospadiasEsr2
InfertilityEsr1
Infertility, FemaleEsr1 , Esr2
Infertility, MaleEsr1
Inflammatory Bowel Disease 11Esr2
Inflammatory Bowel DiseasesEsr2
Ischemic Attack, TransientEsr1 , Esr2
LeiomyomaEsr1
LeukemiaEsr1
Leukemia, MyeloidEsr2
Leydig Cell TumorEsr1
LithiasisEsr2
Liver NeoplasmsEsr1
Lung InjuryEsr2
Lung NeoplasmsEsr1
Lupus Erythematosus, SystemicEsr2
LymphangioleiomyomatosisEsr1
Macular DegenerationEsr1
Mammary Neoplasms, AnimalEsr1 , Esr2
Mammary Neoplasms, ExperimentalEsr1 , Esr2
MedulloblastomaEsr2
MelanomaEsr1 , Esr2
Melanoma, ExperimentalEsr2
MesotheliomaEsr1
Migraine DisordersEsr1
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1Esr1
Mild Cognitive ImpairmentEsr2
Musculoskeletal PainEsr1
Myasthenia GravisEsr2
Myocardial InfarctionEsr1
Myocardial Reperfusion InjuryEsr1 , Esr2
Neoplasm MetastasisEsr1
Neoplasm Recurrence, LocalEsr1
ObesityEsr1 , Esr2
OligospermiaEsr1
OsteoarthritisEsr1
Osteoarthritis, HandEsr1 , Esr2
Osteoarthritis, HipEsr1
Osteoarthritis, KneeEsr1 , Esr2
OsteoporosisEsr1 , Esr2
Osteoporosis, PostmenopausalEsr1 , Esr2
Osteoporotic FracturesEsr1 , Esr2
Ovarian NeoplasmsEsr1
Parkinson DiseaseEsr2
Parkinsonian DisordersEsr1
PeritonitisEsr1 , Esr2
Pituitary NeoplasmsEsr2
PleurisyEsr1
Pre-EclampsiaEsr2
Prostatic HyperplasiaEsr1 , Esr2
Prostatic Intraepithelial NeoplasiaEsr1 , Esr2
Prostatic NeoplasmsEsr1 , Esr2
Psychoses, Substance-InducedEsr1
Retinal DegenerationEsr2
Scleroderma, SystemicEsr1 , Esr2
SepsisEsr2
Shock, HemorrhagicEsr1 , Esr2
Spinal Cord InjuriesEsr1 , Esr2 , Gper1
Spinal FracturesEsr1
SplenomegalyEsr2
StrokeEsr2
Subarachnoid HemorrhageEsr1
Urinary Bladder NeoplasmsEsr1 , Esr2
Urination DisordersEsr1 , Esr2
Varicose UlcerEsr1 , Esr2
VitiligoEsr1
Vulvar Lichen SclerosusEsr1 , Esr2
Pathway Annotations Associated with Genes in the bisphenol A response pathway
Phenotype Annotations Associated with Genes in the bisphenol A response pathway

References Associated with the bisphenol A response pathway:

Ontology Path Diagram:

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