BISPHENOL A RESPONSE PATHWAY (PW:0001511)

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Description

Bisphenols represent a large family of compounds used in the manufacture of various consumer products of which the most widely used is bisphenol A (BPA) - [2,2-bis(4-hydroxyphenyl)propane]. BPA is used in the production of many types of plastics, the lining of food containers, medical and dental devices, thermal paper. The high levels of BPA production underlie its presence in the environment. In addition, BPA can also be found in food due to its leaching out of containers. BPA is an endocrine

Pathway Diagram:

Elsevier Inc. Bisphenol A ---> thermal paper Bisphenol A ---> plastic wares Esr downstream effects Gper1 activation of growth factor signaling and downstream pathways reproductive/birth defects/developmental Esr1 Esr2 bisphenol A degradation pathway estrogen signaling pathway titanium dioxide nanoparticle response pathway anatase Bisphenol A BPA-adducts Bisphenol A ---- Gper1 Bisphenol A ---- Esr2 Bisphenol A ---> medical devices Bisphenol A --+> Esr2 Bisphenol A ---- Esr1 Bisphenol A --+> Esr1 Bisphenol A --+> Gper1 Bisphenol A ---> chromosomal aberrations bisphenol A degradation pathway ---| environmental contamination anatase ---> titanium dioxide nanoparticle response pathway DNA Damage medical devices thermal paper beverage/food cans plastic wares Bisphenol A ---> beverage/food cans photoelectrocatalysis photoelectrocatalysis ---| environmental contamination chromosomal aberrations Bisphenol A ---> BPA-adducts Bisphenol A ---> DNA Damage cardiovascular/kidney/respiratory Bisphenol A ---- cardiovascular/kidney/respiratory diabetes/obesity immunity/cancer food contamination environmental contamination
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Genes in Pathway:

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bisphenol A response pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:8547944
RGD:8548497
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:8547944
RGD:8548497
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:8547944
RGD:8548497

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the bisphenol A response pathway
Phenotype Annotations Associated with Genes in the bisphenol A response pathway

References Associated with the bisphenol A response pathway:

Ontology Path Diagram:

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