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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | decreases expression | EXP | | 6480464 | Pilocarpine results in decreased expression of GRM1 protein | CTD | PMID:11463519 | (+)-pilocarpine | increases expression | EXP | | 6480464 | Pilocarpine results in increased expression of GRM1 protein | CTD | PMID:11463519 | (S)-amphetamine | affects response to substance | ISO | RGD:731957 | 6480464 | GRM1 protein affects the susceptibility to Dextroamphetamine | CTD | PMID:11566502 | (S)-amphetamine | multiple interactions | ISO | RGD:731957 | 6480464 | GRM1 protein affects the reaction [Dextroamphetamine results in increased expression of PDYN mRNA] | CTD | PMID:11566502 | 17beta-estradiol | increases activity | EXP | | 6480464 | Estradiol results in increased activity of GRM1 protein | CTD | PMID:15901789 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:731957 | 6480464 | Tetrachlorodibenzodioxin affects the expression of GRM1 mRNA | CTD | PMID:21570461 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | RGD:731957 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GRM1 mRNA | CTD | PMID:19285098 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:731957 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of GRM1 mRNA | CTD | PMID:18648102 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of GRM1 mRNA | CTD | PMID:22504374 | ammonia | multiple interactions | EXP | | 6480464 | Ammonia inhibits the reaction [GRM1 protein results in increased phosphorylation of MAP2 protein] | CTD | PMID:15893642 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GRM1 mRNA | CTD | PMID:16483693 | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of GRM1 mRNA | CTD | PMID:11418936 | butan-1-ol | affects localization | ISO | RGD:736303 | 6480464 | 1-Butanol affects the localization of GRM1 protein | CTD | PMID:15470141 | butan-1-ol | multiple interactions | ISO | RGD:736303 | 6480464 | PLD2 protein affects the reaction [1-Butanol affects the localization of GRM1 protein] | CTD | PMID:15470141 | caffeine | decreases expression | EXP | | 6480464 | Caffeine results in decreased expression of GRM1 protein | CTD | PMID:15998294 | calcium atom | multiple interactions | EXP | | 6480464 | 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; more ... | CTD | PMID:14622174 | calcium(0) | multiple interactions | EXP | | 6480464 | 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; more ... | CTD | PMID:14622174 | cocaine | affects response to substance | ISO | RGD:731957 | 6480464 | GRM1 affects the susceptibility to Cocaine | CTD | PMID:19597494 | diazinon | increases expression | EXP | | 6480464 | Diazinon results in increased expression of GRM1 mRNA | CTD | PMID:19440498 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of GRM1 mRNA | CTD | PMID:15620428 | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of GRM1 mRNA | CTD | PMID:20655511 | flufenamic acid | multiple interactions | EXP | | 6480464 | Flufenamic Acid inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; more ... | CTD | PMID:14622174 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of GRM1 gene | CTD | PMID:22079235 | haloperidol | increases expression | EXP | | 6480464 | Haloperidol results in increased expression of GRM1 mRNA | CTD | PMID:15860345 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of GRM1 mRNA | CTD | PMID:18419818 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of GRM1 mRNA | CTD | PMID:22504374 | morphine | increases expression | EXP | | 6480464 | Morphine results in increased expression of GRM1 mRNA | CTD | PMID:15183518 | potassium atom | multiple interactions | EXP | | 6480464 | Potassium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] | CTD | PMID:14622174 | quinine | affects response to substance | EXP | | 6480464 | GRM1 protein affects the susceptibility to Quinine | CTD | PMID:19174448 | quinoline | decreases activity | ISO | RGD:731957 | 6480464 | quinoline analog results in decreased activity of GRM1 protein | CTD | PMID:18005334 | sodium atom | multiple interactions | EXP | | 6480464 | Sodium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] | CTD | PMID:14622174 | theophylline | decreases expression | EXP | | 6480464 | Theophylline results in decreased expression of GRM1 protein | CTD | PMID:15998294 | toluene | affects expression | EXP | | 6480464 | Toluene affects the expression of GRM1 mRNA | CTD | PMID:21827849 | zinc atom | decreases expression | ISO | RGD:736303 | 6480464 | Zinc deficiency results in decreased expression of GRM1 mRNA | CTD | PMID:18356318 | zinc(0) | decreases expression | ISO | RGD:736303 | 6480464 | Zinc deficiency results in decreased expression of GRM1 mRNA | CTD | PMID:18356318 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsPhenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Calcium signaling pathway |
| Estrogen signaling pathway | |
| Gap junction | |
| Glutamatergic synapse | |
| Long-term depression | |
| Long-term potentiation | |
| Neuroactive ligand-receptor interaction | |
| Retrograde endocannabinoid signaling | |
Phenotype AnnotationsReferences - curated| 1. |
Agassandian K and Cassell MD, Brain Res. 2008 Aug 21;1226:39-55. Epub 2008 Jun 11. |
| 2. |
Brakeman PR, etal., Nature 1997 Mar 20;386(6622):284-8. |
| 3. |
Gee CE, etal., J Physiol 2003 Feb 1;546(Pt 3):655-64. |
| 4. |
Gillard SE, etal., J Comp Neurol 2003 Jun 30;461(3):317-32. |
| 5. |
GOA data from the GO Consortium |
| 6. |
Kim SJ, etal., Nature 2003 Nov 20;426(6964):285-91. Epub 2003 Nov 12. |
| 7. |
Kitano J, etal., J Neurosci 2002 Feb 15;22(4):1280-9. |
| 8. |
Kuo J, etal., Endocrinology. 2009 Mar;150(3):1369-76. Epub 2008 Oct 23. |
| 9. |
Kushmerick C, etal., J Neurosci 2004 Jun 30;24(26):5955-65. |
| 10. |
Maeda J, etal., Neurosci Lett 2003 Jan 23;336(3):171-4. |
| 11. |
MGD data from the GO Consortium |
| 12. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 13. |
Neugebauer V, etal., J Neurosci 2003 Jan 1;23(1):52-63. |
| 14. |
Online Mendelian Inheritance in Man, OMIM (TM). |
| 15. |
Pampillo M, etal., Neurosci Lett 2002 Jul 19;327(2):95-8. |
| 16. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 17. |
Poisik OV, etal., J Neurosci 2003 Jan 1;23(1):122-30. |
| 18. |
RGD automated import pipeline for gene-chemical interactions |
| 19. |
Soloviev MM, etal., Biochim Biophys Acta 1999 Jul 7;1446(1-2):161-6. |
| 20. |
Wyneken U, etal., Neuroscience. 2001;102(1):65-74. |
| 21. |
Xiao B, etal., Neuron 1998 Oct;21(4):707-16. |
References - uncurated| PubMed | 10469171 |
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RGD Disease Portals| Grm1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Grm1 (Rattus norvegicus) |
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| GRM1 (Homo sapiens) |
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| Grm1 (Mus musculus) |
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Position Markers| D1Got3 |
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| D1Arb40 |
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| GRM1 |
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| GDB:4585461 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001114330 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_017011 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06000288 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06000289 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06000290 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06000291 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06000292 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06000293 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06000294 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06000295 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06000306 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01001312 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01001313 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01001314 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01001315 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01001316 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01001317 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01001318 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01001319 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01001320 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01001321 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01001322 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473994 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M61099 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X57569 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y18809 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y18810 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y18811 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y18812 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_017011 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_058707 | |||||||||||||||||||||||||
| Peptide Label: | isoform alpha precursor | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001114330 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001107802 | |||||||||||||||||||||||||
| Peptide Label: | isoform beta precursor | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001107802 | (Get FASTA) |
| NP_058707 | (Get FASTA) | |
| GenBank Protein | AAA19497 | (Get FASTA) |
| CAA40799 | (Get FASTA) | |
| CAB51054 | (Get FASTA) | |
| CAB51055 | (Get FASTA) | |
| CAB51056 | (Get FASTA) | |
| CAB51057 | (Get FASTA) | |
| EDL93710 | (Get FASTA) | |
| EDL93711 | (Get FASTA) | |
| P23385 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| BIND | 144392 | |
| Ensembl Genes | ENSRNOG00000014290 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000019319 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000047790 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000019319 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000044325 | UniProtKB/TrEMBL | |
| Entrez Gene | 24414 | ENTREZGENE |
| Germonline | ENSRNOG00000014290 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 649 | ENTREZGENE |
| InterPro | ANF_lig_bd_rcpt | UniProtKB/Swiss-Prot |
| GPCR_3 | UniProtKB/Swiss-Prot | |
| GPCR_3_9-Cys_dom | UniProtKB/Swiss-Prot | |
| GPCR_3_C | UniProtKB/Swiss-Prot | |
| GPCR_3_CS | UniProtKB/Swiss-Prot | |
| GPCR_3_mtglu_rcpt | UniProtKB/Swiss-Prot | |
| GPCR_3_mtglu_rcpt_1 | UniProtKB/Swiss-Prot | |
| Metabotropic_Glu_rcpt_Homer-bd | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:24414 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | 7tm_3 | UniProtKB/Swiss-Prot |
| ANF_receptor | UniProtKB/Swiss-Prot | |
| GluR_Homer-bdg | UniProtKB/Swiss-Prot | |
| NCD3G | UniProtKB/Swiss-Prot | |
| PRINTS | GPCRMGR | UniProtKB/Swiss-Prot |
| MTABOTROPC1R | UniProtKB/Swiss-Prot | |
| MTABOTROPICR | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F3_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F3_2 | UniProtKB/Swiss-Prot | |
| G_PROTEIN_RECEP_F3_3 | UniProtKB/Swiss-Prot | |
| G_PROTEIN_RECEP_F3_4 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.87787 | ENTREZGENE |
| UniProt | D3ZSM4_RAT | UniProtKB/TrEMBL |
| G3V7U1_RAT | UniProtKB/TrEMBL | |
| GRM1_RAT | UniProtKB/Swiss-Prot | |
| Q9WTJ1_RAT | UniProtKB/TrEMBL | |
| Q9WUY1_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2003-04-09 | Grm1 | glutamate receptor, metabotropic 1 | Symbol and Name updated | 2574 | APPROVED | ||
| 2003-03-12 | Grm1 | glutamate receptor, metabotropic 1 | Gprc1a | G protein coupled receptor, family C, group 1, member A | Data Merged | 2447 | PROVISIONAL |
| 2002-11-06 | Grm1 | glutamate receptor, metabotropic 1 | Glutamate receptor, metabotropic 1 | Name updated | 2225 | APPROVED | |
| 2002-06-10 | Gprc1a | G protein coupled receptor, family C, group 1, member A | Symbol and Name status set to approved | 1490 | APPROVED | ||
| 2002-06-10 | Grm1 | Glutamate receptor, metabotropic 1 | Symbol and Name status set to approved | 1490 | APPROVED |
| More on Grm1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2742 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.