RGD Reference Report - Homer: a protein that selectively binds metabotropic glutamate receptors. - Rat Genome Database

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Homer: a protein that selectively binds metabotropic glutamate receptors.

Authors: Brakeman, PR  Lanahan, AA  O'Brien, R  Roche, K  Barnes, CA  Huganir, RL  Worley, PF 
Citation: Brakeman PR, etal., Nature 1997 Mar 20;386(6622):284-8.
RGD ID: 633021
Pubmed: PMID:9069287   (View Abstract at PubMed)
DOI: DOI:10.1038/386284a0   (Journal Full-text)

Spatial localization and clustering of membrane proteins is critical to neuronal development and synaptic plasticity. Recent studies have identified a family of proteins, the PDZ proteins, that contain modular PDZ domains and interact with synaptic ionotropic glutamate receptors and ion channels. PDZ proteins are thought to have a role in defining the cellular distribution of the proteins that interact with them. Here we report a novel dendritic protein, Homer, that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors. Homer is highly divergent from known PDZ proteins and seems to represent a novel family. The Homer gene is also distinct from members of the PDZ family in that its expression is regulated as an immediate early gene and is dynamically responsive to physiological synaptic activity, particularly during cortical development. This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
G protein-coupled glutamate receptor signaling pathway  IDA 633021 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dendritic shaft  IDA 633021 RGD 
excitatory synapse located_inIDA 633021 RGD 
neuronal cell body  IDA 633021 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding  IPIHomer1 (Rattus norvegicus)633021 RGD 
protein binding  IPIGrm1 (Rattus norvegicus)633021 RGD 
signaling receptor binding  IDA 633021 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grm1  (glutamate metabotropic receptor 1)
Homer1  (homer scaffold protein 1)

Objects referenced in this article
Gene Grm1 glutamate receptor, metabotropic 1 Mus musculus

Additional Information