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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | decreases expression | ISO | RGD:2742 | 6480464 | Pilocarpine results in decreased expression of GRM1 protein | CTD | PMID:11463519 | (+)-pilocarpine | increases expression | ISO | RGD:2742 | 6480464 | Pilocarpine results in increased expression of GRM1 protein | CTD | PMID:11463519 | (S)-amphetamine | affects response to substance | EXP | | 6480464 | GRM1 protein affects the susceptibility to Dextroamphetamine | CTD | PMID:11566502 | (S)-amphetamine | multiple interactions | EXP | | 6480464 | GRM1 protein affects the reaction [Dextroamphetamine results in increased expression of PDYN mRNA] | CTD | PMID:11566502 | 17beta-estradiol | increases activity | ISO | RGD:2742 | 6480464 | Estradiol results in increased activity of GRM1 protein | CTD | PMID:15901789 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of GRM1 mRNA | CTD | PMID:21570461 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GRM1 mRNA | CTD | PMID:19285098 | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of GRM1 mRNA | CTD | PMID:18648102 | 6-propyl-2-thiouracil | increases expression | ISO | RGD:2742 | 6480464 | Propylthiouracil results in increased expression of GRM1 mRNA | CTD | PMID:22504374 | ammonia | multiple interactions | ISO | RGD:2742 | 6480464 | Ammonia inhibits the reaction [GRM1 protein results in increased phosphorylation of MAP2 protein] | CTD | PMID:15893642 | ammonium chloride | affects expression | ISO | RGD:2742 | 6480464 | Ammonium Chloride affects the expression of GRM1 mRNA | CTD | PMID:16483693 | amphetamine | increases expression | ISO | RGD:2742 | 6480464 | Amphetamine results in increased expression of GRM1 mRNA | CTD | PMID:11418936 | butan-1-ol | affects localization | ISO | RGD:736303 | 6480464 | 1-Butanol affects the localization of GRM1 protein | CTD | PMID:15470141 | butan-1-ol | multiple interactions | ISO | RGD:736303 | 6480464 | PLD2 protein affects the reaction [1-Butanol affects the localization of GRM1 protein] | CTD | PMID:15470141 | caffeine | decreases expression | ISO | RGD:2742 | 6480464 | Caffeine results in decreased expression of GRM1 protein | CTD | PMID:15998294 | calcium atom | multiple interactions | ISO | RGD:2742 | 6480464 | 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; more ... | CTD | PMID:14622174 | calcium(0) | multiple interactions | ISO | RGD:2742 | 6480464 | 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; more ... | CTD | PMID:14622174 | cocaine | affects response to substance | EXP | | 6480464 | GRM1 affects the susceptibility to Cocaine | CTD | PMID:19597494 | diazinon | increases expression | ISO | RGD:2742 | 6480464 | Diazinon results in increased expression of GRM1 mRNA | CTD | PMID:19440498 | dibutyl phthalate | decreases expression | ISO | RGD:2742 | 6480464 | Dibutyl Phthalate results in decreased expression of GRM1 mRNA | CTD | PMID:15620428 | ethanol | decreases expression | ISO | RGD:2742 | 6480464 | Ethanol results in decreased expression of GRM1 mRNA | CTD | PMID:20655511 | flufenamic acid | multiple interactions | ISO | RGD:2742 | 6480464 | Flufenamic Acid inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; more ... | CTD | PMID:14622174 | furan | increases methylation | ISO | RGD:2742 | 6480464 | furan results in increased methylation of GRM1 gene | CTD | PMID:22079235 | haloperidol | increases expression | ISO | RGD:2742 | 6480464 | Haloperidol results in increased expression of GRM1 mRNA | CTD | PMID:15860345 | methamphetamine | increases expression | ISO | RGD:2742 | 6480464 | Methamphetamine results in increased expression of GRM1 mRNA | CTD | PMID:18419818 | methimazole | increases expression | ISO | RGD:2742 | 6480464 | Methimazole results in increased expression of GRM1 mRNA | CTD | PMID:22504374 | morphine | increases expression | ISO | RGD:2742 | 6480464 | Morphine results in increased expression of GRM1 mRNA | CTD | PMID:15183518 | potassium atom | multiple interactions | ISO | RGD:2742 | 6480464 | Potassium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] | CTD | PMID:14622174 | quinine | affects response to substance | ISO | RGD:2742 | 6480464 | GRM1 protein affects the susceptibility to Quinine | CTD | PMID:19174448 | quinoline | decreases activity | EXP | | 6480464 | quinoline analog results in decreased activity of GRM1 protein | CTD | PMID:18005334 | sodium atom | multiple interactions | ISO | RGD:2742 | 6480464 | Sodium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] | CTD | PMID:14622174 | theophylline | decreases expression | ISO | RGD:2742 | 6480464 | Theophylline results in decreased expression of GRM1 protein | CTD | PMID:15998294 | toluene | affects expression | ISO | RGD:2742 | 6480464 | Toluene affects the expression of GRM1 mRNA | CTD | PMID:21827849 | zinc atom | decreases expression | ISO | RGD:736303 | 6480464 | Zinc deficiency results in decreased expression of GRM1 mRNA | CTD | PMID:18356318 | zinc(0) | decreases expression | ISO | RGD:736303 | 6480464 | Zinc deficiency results in decreased expression of GRM1 mRNA | CTD | PMID:18356318 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Calcium signaling pathway |
| Estrogen signaling pathway | |
| Gap junction | |
| Glutamatergic synapse | |
| Long-term depression | |
| Long-term potentiation | |
| Neuroactive ligand-receptor interaction | |
| Retrograde endocannabinoid signaling | |
Phenotype Annotations
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References - curated| 1. |
Brakeman PR, etal., Nature 1997 Mar 20;386(6622):284-8. |
| 2. |
Kaupmann K, etal., Nature 1997 Mar 20;386(6622):239-46. |
| 3. |
MGD and Homologene mouse data transfer |
| 4. |
MGD data from the GO Consortium |
| 5. |
MGD IEA |
| 6. |
Online Mendelian Inheritance in Man, OMIM (TM). |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
RGD automated import pipeline |
| 9. |
RGD automated import pipeline for gene-chemical interactions |
| 10. |
Wyneken U, etal., Neuroscience. 2001;102(1):65-74. |
| 11. |
Xiao B, etal., Neuron 1998 Oct;21(4):707-16. |
References - uncurated| PubMed | 10349636 |
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RGD Disease Portals| Grm1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Grm1 (Mus musculus) |
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| GRM1 (Homo sapiens) |
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| Grm1 (Rattus norvegicus) |
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Position Markers| Grm1 |
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| RH126026 |
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| D1Arb40 |
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| Grm1 |
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| Grm1 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001114333 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_016976 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHY01083261 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01083262 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083263 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083264 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083265 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083266 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083267 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083268 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083269 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083270 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083271 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083272 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083273 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083274 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083275 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083276 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083277 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083278 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083279 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083280 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083281 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083282 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083283 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083284 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083285 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083286 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083287 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083288 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083289 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083290 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083291 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01083292 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC100149 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC155834 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC158641 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC164170 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC171336 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF320126 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AI835246 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK015466 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK132901 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK140273 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC067057 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC079566 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466562 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CJ129468 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U89891 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_016976 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_058672 | |||||||||||||||||||||||||
| Peptide Label: | isoform alpha precursor | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001114333 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001107805 | |||||||||||||||||||||||||
| Peptide Label: | isoform beta precursor | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001107805 | (Get FASTA) |
| NP_058672 | (Get FASTA) | |
| GenBank Protein | AAB48099 | (Get FASTA) |
| AAG41991 | (Get FASTA) | |
| AAH67057 | (Get FASTA) | |
| AAH79566 | (Get FASTA) | |
| BAE21411 | (Get FASTA) | |
| BAE24310 | (Get FASTA) | |
| EDL03523 | (Get FASTA) | |
| P97772 | (Get FASTA) |
Promoters| RGD ID: | 6819410 | ||||||||||
| Promoter ID: | MM_KWN:3535 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Brain | ||||||||||
| Transcripts: | UC007EJH.1 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000019828 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000037255 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000044306 | ENTREZGENE |
| Entrez Gene | 14816 | ENTREZGENE |
| Germonline | ENSMUSG00000019828 | |
| HomoloGene Group ID | 649 | ENTREZGENE |
| InterPro | ANF_lig-bd_rcpt | UniProtKB/Swiss-Prot |
| GPCR_3 | UniProtKB/Swiss-Prot | |
| GPCR_3_9-Cys_dom | UniProtKB/Swiss-Prot | |
| GPCR_3_C | UniProtKB/Swiss-Prot | |
| GPCR_3_CS | UniProtKB/Swiss-Prot | |
| GPCR_3_mtglu_rcpt | UniProtKB/Swiss-Prot | |
| GPCR_3_mtglu_rcpt_1 | UniProtKB/Swiss-Prot | |
| Metabotropic_Glu_rcpt_Homer-bd | UniProtKB/Swiss-Prot | |
| IPI | IPI00110402 | UniProtKB/Swiss-Prot |
| IPI00281619 | UniProtKB/Swiss-Prot | |
| IPI00281620 | UniProtKB/Swiss-Prot | |
| IPI00654056 | UniProtKB/TrEMBL | |
| KEGG Report | mmu:14816 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:1351338 | ENTREZGENE |
| Pfam | 7tm_3 | UniProtKB/Swiss-Prot |
| ANF_receptor | UniProtKB/Swiss-Prot | |
| GluR_Homer-bdg | UniProtKB/Swiss-Prot | |
| NCD3G | UniProtKB/Swiss-Prot | |
| PRINTS | GPCRMGR | UniProtKB/Swiss-Prot |
| MTABOTROPC1R | UniProtKB/Swiss-Prot | |
| MTABOTROPICR | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F3_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F3_2 | UniProtKB/Swiss-Prot | |
| G_PROTEIN_RECEP_F3_3 | UniProtKB/Swiss-Prot | |
| G_PROTEIN_RECEP_F3_4 | UniProtKB/Swiss-Prot | |
| UniGene | Mm.391904 | ENTREZGENE |
| Mm.482986 | ENTREZGENE | |
| UniProt | GRM1_MOUSE | UniProtKB/Swiss-Prot |
| Q3USM1_MOUSE | UniProtKB/TrEMBL | |
| Q3V0U2_MOUSE | UniProtKB/TrEMBL |
| More on Grm1 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 731957 |
| Created: | 2004-01-12 |
| Species: | Mus musculus |
| Last Modified: | 2013-05-14 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




