RGD Reference Report - Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons. - Rat Genome Database

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Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons.

Authors: Voulalas, Pamela J  Holtzclaw, Lynne  Wolstenholme, Jennifer  Russell, James T  Hyman, Steven E 
Citation: Voulalas PJ, etal., J Neurosci. 2005 Apr 13;25(15):3763-73. doi: 10.1523/JNEUROSCI.4574-04.2005.
RGD ID: 405100223
Pubmed: PMID:15829628   (View Abstract at PubMed)
PMCID: PMC6724927   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.4574-04.2005   (Journal Full-text)

Striatal medium spiny neurons are an important site of convergence for signaling mediated by the neurotransmitters dopamine and glutamate. We report that in striatal neurons in primary culture, signaling through group I metabotropic glutamate receptors (mGluRs) 1/5 and the D1 class of dopamine receptors (DRs) 1/5 converges to increase phosphorylation of the mitogen-activated protein kinase ERK2 (extracellular signal-regulated kinase 2). Induction of mitogen-activated protein kinase kinase-dependent signaling cascades by either mGluR1/5 or DR1/5 gave rise to increases in phosphorylation of ERK2. Coactivation of mGluR1/5 and DR1/5 with (S)-3,5-dihydroxyphenylglycine and (+)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride enhanced the phosphorylation of ERK2. This interaction between mGluR1/5 and DR1/5 required protein kinase C (PKC), because the PKC inhibitors calphostin C, bisindolylmaleimide I, and Gö6976 blocked DR1/5-enhanced phosphorylation of ERK2. Use of the phosphatase inhibitors calyculin and okadaic acid indicated that inhibition of protein phosphatases 1 and 2A dramatically enhanced ERK2 phosphorylation by mGluR1/5. Coactivation of mGluR1/5 and DR1/5 also enhanced cAMP-response element binding protein (CREB) phosphorylation (compared with each receptor agonist alone) but did not enhance CREB-mediated transcriptional activity. Thus, signal transduction pathways activated by DR1/5 and mGluR5 interact to modify downstream events in striatal neurons while retaining numerous regulatory checkpoints.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuron projection  IDA 405100223; 405100223MMO:0000662RGD 
neuronal cell body  IDA 405100223; 405100223MMO:0000662RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grm1  (glutamate metabotropic receptor 1)
Grm5  (glutamate metabotropic receptor 5)


Additional Information