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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:34680
Term: dipentyl phthalate
Definition: A phthalate ester that is the dipentyl ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C034171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDdi-n-pentyl phthalate analog binds to ESR1 protein; di-n-pentyl phthalate binds to ESR1 proteinPMID:15464722 PMID:20822795
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDdi-n-pentyl phthalate binds to and results in increased activity of ESR1 protein; di-n-pentyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [di-n-pentyl phthalate binds to and results in increased activity of ESR1 protein]PMID:15840436 PMID:28571686 PMID:33049310
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