Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Tamoxifen results in decreased expression of ESR1 mRNA; Tamoxifen results in decreased expression of ESR1 mRNA alternative form; Tamoxifen results in decreased expression of ESR1 protein; Tamoxifen results in decreased expression of ESR1 protein alternative form
[arsenic trioxide co-treated with Tamoxifen] results in decreased methylation of ESR1 gene; [arsenic trioxide co-treated with Tamoxifen] results in increased expression of ESR1 mRNA; [arsenic trioxide co-treated with Tamoxifen] results in increased expression of ESR1 protein; [ESR1 protein mutant form co-treated with Tamoxifen] results in increased expression of CAR2 mRNA; [sodium arsenite co-treated with Tamoxifen] results in increased expression of ESR1 protein; [Tamoxifen co-treated with BRCA1 protein mutant form] results in decreased expression of ESR1 protein; ESR1 protein affects the reaction [Tamoxifen results in increased expression of MMD2 mRNA]; ESR1 protein mutant form inhibits the reaction [Tamoxifen results in decreased expression of AQP1 mRNA]; ESR1 protein mutant form inhibits the reaction [Tamoxifen results in decreased expression of SLC9A3 mRNA]; Tamoxifen binds to and results in increased activity of ESR1 protein mutant form; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of AQP1 mRNA]; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of AQP9 mRNA]; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of AQP9 protein]; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of CAR2 mRNA]; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of SLC9A3 mRNA]; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of SLC9A3 protein]; Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of ESR1 protein]; Tamoxifen promotes the reaction [Estradiol results in increased expression of ESR1 protein]; Tamoxifen promotes the reaction [Linseed Oil results in decreased expression of ESR1 protein]
4-hydroxy-N-desmethyltamoxifen inhibits the reaction [[Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein]; [CARM1 protein binds to ESR1 protein] which affects the susceptibility to Tamoxifen; [ERBB2 protein results in increased activity of ESR1 protein] which results in decreased susceptibility to Tamoxifen; [Estradiol co-treated with Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [EZH2 protein results in decreased expression of ESR1 protein] which results in decreased susceptibility to Tamoxifen; [NCOA1 protein binds to ESR1 protein] which results in increased susceptibility to Tamoxifen; [pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen; [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of ESR1 protein; [Tamoxifen binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of ANKRD28 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of CCN3 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of CSF2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of EGFR mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of EGFR protein; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of ENC1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of HAS2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of KCNN4 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of LINC00312 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of LMCD1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of PLAU mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of RGS16 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of SLN mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of TGFBI mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of TNFRSF11B mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of TXNIP mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of BGLAP mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of BSP mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of CA12 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of CRISPLD2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of EDNRA mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of EIF1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of ENPP2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of FHL2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of G0S2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of GRK5 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of HEG1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of HK1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of IDH2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of ISG20 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of KCTD12 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of KLRC2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of LPL mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of MSMB mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of NPR2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of OSBPL3 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of PTPRE mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of RET mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of RGS4 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of RHOBTB3 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of RIPOR2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of SEMA3B mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of SGK1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of SYBU mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of TIPARP mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of TMOD1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of TMPRSS3 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of ZNF395 mRNA; [Tamoxifen co-treated with Estradiol] results in decreased expression of ESR1 mRNA; [Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA alternative form; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein alternative form; [Tamoxifen results in increased activity of ESR1 protein] which results in increased expression of PTGS2 mRNA; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to MYC promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to TFF1 promoter]]; benzamide analog inhibits the reaction [Tamoxifen results in increased phosphorylation of and results in increased localization of ESR1 protein]; bisphenol A inhibits the reaction [Tamoxifen results in decreased expression of ESR1 mRNA]; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]]; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein]]; CARM1 protein promotes the reaction [Tamoxifen results in increased activity of ESR1 protein]; ESR1 protein affects the reaction [GATA3 protein affects the susceptibility to Tamoxifen]; ESR1 protein affects the reaction [Tamoxifen results in decreased expression of CAP2 mRNA]; ESR1 protein affects the reaction [Tamoxifen results in decreased expression of F2R mRNA]; ESR1 protein affects the reaction [Tamoxifen results in decreased expression of LGR5 mRNA]; ESR1 protein affects the reaction [Tamoxifen results in decreased expression of NEK7 mRNA]; ESR1 protein affects the reaction [Tamoxifen results in increased expression of FLOT1 mRNA]; ESR1 protein affects the reaction [Tamoxifen results in increased expression of FOXO1 mRNA]; ESR1 protein affects the reaction [Tamoxifen results in increased expression of G0S2 mRNA]; ESR1 protein affects the reaction [Tamoxifen results in increased expression of KLRC3 mRNA]; ESR1 protein inhibits the reaction [Tamoxifen results in decreased expression of FOXM1 mRNA]; ESR1 protein promotes the reaction [Tamoxifen results in decreased expression of FOXM1 protein]; ESR1 protein promotes the reaction [Tamoxifen results in increased abundance of Lipids]; Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [bisphenol A results in decreased expression of ESR1 protein]]; FKBPL protein inhibits the reaction [Tamoxifen results in increased phosphorylation of ESR1 protein]; FOXA1 protein affects the reaction [Tamoxifen affects the activity of ESR1 protein]; FOXL2 protein inhibits the reaction [[Tamoxifen results in increased activity of ESR1 protein] which results in increased expression of PTGS2 mRNA]; FOXM1 protein affects the reaction [ESR1 protein results in increased susceptibility to Tamoxifen]; HDAC4 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein]; methoxyacetic acid promotes the reaction [Tamoxifen results in increased activity of ESR1 protein]; NCOR2 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein]; Paclitaxel inhibits the reaction [Tamoxifen binds to ESR1 protein]; Plant Extracts promotes the reaction [Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA]]; Tamoxifen affects the reaction [Quercetin affects the expression of ESR1 mRNA alternative form]; Tamoxifen analog binds to and results in decreased activity of ESR1 protein; Tamoxifen binds to and affects the activity of ESR1 protein; Tamoxifen binds to and results in decreased activity of ESR1 protein; Tamoxifen binds to and results in increased activity of ESR1 protein; Tamoxifen inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Tamoxifen inhibits the reaction [[bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]; Tamoxifen inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]; Tamoxifen inhibits the reaction [[ESR1 protein binds to NCOR1 protein] which binds to TFF1 promoter]; Tamoxifen inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]; Tamoxifen inhibits the reaction [bisphenol A results in decreased expression of ESR1 protein]; Tamoxifen inhibits the reaction [bisphenol A results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [butylbenzyl phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Chlorpyrifos results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Coumestrol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [di-n-pentyl phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dibutyl Phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [dicyclohexyl phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [diethyl phthalate promotes the reaction [ESR1 protein binds to CYP19A1 promoter]]; Tamoxifen inhibits the reaction [Diethylhexyl Phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [diisobutyl phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to CDKN1A promoter]; Tamoxifen inhibits the reaction [ESR1 protein binds to CNOT1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to CYP19A1 promoter]; Tamoxifen inhibits the reaction [ESR1 protein binds to DHX30 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to EP300 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to ILK protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to MGMT protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOA1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOA2 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOA6 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOR1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOR2 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NELFB protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NFKBIB protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NR0B1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NR0B2 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NRIP1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to PELP1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to PRAME protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to TRRAP protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to TXNRD1 protein]; Tamoxifen inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Estradiol binds to ESR1 protein]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to AICDA promoter]]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to ESR1 protein]]; Tamoxifen inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Tamoxifen inhibits the reaction [Estrogens results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [MEN1 protein binds to ESR1 protein]; Tamoxifen inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [phthalic acid metabolite binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]; Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA]; Tamoxifen inhibits the reaction [Triiodothyronine results in decreased expression of ESR1 mRNA]; Tamoxifen promotes the reaction [[[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter] which results in increased expression of E2F1 mRNA]; Tamoxifen promotes the reaction [[ESR1 protein binds to AGR2 promoter] which results in increased expression of AGR2 mRNA]; Tamoxifen promotes the reaction [[ESR1 protein binds to NCOA3 protein] which binds to TFF1 promoter]; Tamoxifen promotes the reaction [[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter]; Tamoxifen promotes the reaction [bisphenol A results in increased activity of ESR1 protein mutant form]; Tamoxifen promotes the reaction [Coumestrol results in increased activity of ESR1 protein mutant form]; Tamoxifen promotes the reaction [ESR1 protein binds to AGR2 promoter]; Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]; Tamoxifen promotes the reaction [ESR1 protein binds to ESR1 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to ESR2 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to FOXL2 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to JUN protein binds to MAPK12 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to KLRC3 gene]; Tamoxifen promotes the reaction [ESR1 protein binds to MMP1 promoter]; Tamoxifen promotes the reaction [ESR1 protein binds to MYC promoter]; Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to PGR promoter]; Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to TFF1 promoter]; Tamoxifen promotes the reaction [ESR1 protein modified form binds to JUN protein binds to MAPK12 protein]; Tamoxifen promotes the reaction [Estradiol results in increased activity of ESR1 protein mutant form]; Tamoxifen promotes the reaction [MAPK12 protein binds to ESR1 protein modified form]; Tamoxifen promotes the reaction [MAPK12 protein binds to ESR1 protein]; Tamoxifen promotes the reaction [Quercetin results in decreased expression of ESR1 mRNA]; Tamoxifen promotes the reaction [SP1 protein binds to ESR1 protein]; Tamoxifen results in increased phosphorylation of and results in increased localization of ESR1 protein; TP53 protein inhibits the reaction [Tamoxifen results in increased expression of ESR1 protein]
