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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:80554
Term: N-Desmethyltamoxifen
Definition: A stilbenoid that has formula C25H27NO.
Chemical ID: MESH:C028787
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD4-hydroxy-N-desmethyltamoxifen inhibits the reaction [[Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein]; [Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 proteinPMID:19244106
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