An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID:
MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
[Genistein co-treated with Methoxychlor] results in increased expression of ESR1 mRNA; [Methoxychlor co-treated with Genistein] results in increased expression of ESR1 protein; [o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR1 protein; Methoxychlor inhibits the reaction [Estradiol binds to ESR1 protein]; Methoxychlor inhibits the reaction [FSHB protein results in increased expression of ESR1 mRNA]; Methoxychlor metabolite binds to and results in increased activity of ESR1 protein; Methoxychlor metabolite promotes the reaction [ESR1 protein binds to NCOA1 protein]
[ESR1 gene mutant form results in increased susceptibility to Methoxychlor] which results in decreased expression of CASP3 protein; [ESR1 gene mutant form results in increased susceptibility to Methoxychlor] which results in increased expression of BAX mRNA; [ESR1 gene mutant form results in increased susceptibility to Methoxychlor] which results in increased expression of BCL2 mRNA; [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of ESR1 mRNA; ESR1 gene mutant form promotes the reaction [Methoxychlor results in increased activity of CASP3 protein]; ESR1 gene mutant form promotes the reaction [Methoxychlor results in increased activity of CASP7 protein]; ESR1 gene mutant form promotes the reaction [Methoxychlor results in increased expression of BID mRNA]; ESR1 protein inhibits the reaction [Methoxychlor results in increased expression of ESR2 mRNA]; ESR1 protein inhibits the reaction [Methoxychlor results in increased expression of PGR mRNA]; ESR1 protein promotes the reaction [Methoxychlor results in increased expression of AR mRNA]; ESR1 protein promotes the reaction [Methoxychlor results in increased expression of CYP1A2 mRNA]; ESR1 protein promotes the reaction [Methoxychlor results in increased expression of CYP2C29 mRNA]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]; [Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]; [o,p'-DDT co-treated with Methoxychlor co-treated with Dieldrin] results in increased expression of ESR1 mRNA; Methoxychlor analog binds to and results in increased activity of ESR1 protein; Methoxychlor binds to and results in decreased activity of ESR1 protein; Methoxychlor binds to and results in increased activity of ESR1 protein; Methoxychlor inhibits the reaction [Estradiol binds to ESR1 protein]; Methoxychlor inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to HOXA10 gene]]; Methoxychlor metabolite binds to and results in increased activity of ESR1 protein; Methoxychlor metabolite inhibits the reaction [Genistein binds to and results in increased activity of ESR1 protein]; Methoxychlor metabolite promotes the reaction [Genistein binds to and results in increased activity of ESR1 protein]; Methoxychlor promotes the reaction [ESR1 protein binds to HOXA10 gene]; Tamoxifen inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]
