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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTDAtrazine results in decreased expression of ESR1 mRNAPMID:22285353
Esr1increases expressionEXP 6480464CTDAtrazine results in increased expression of ESR1 mRNA; Atrazine results in increased expression of ESR1 proteinPMID:23200735 PMID:34600026
Esr1multiple interactionsEXP 6480464CTDAtrazine inhibits the reaction [Bucladesine results in increased expression of ESR1 mRNA]; Atrazine inhibits the reaction [Estradiol binds to ESR1 protein]; Quercetin promotes the reaction [Atrazine results in increased expression of ESR1 mRNA]PMID:15056801 PMID:21693180 PMID:23200735
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDAtrazine binds to ESR1 proteinPMID:14579009 PMID:8858116
Esr1increases expressionISOEsr1 (Mus musculus)6480464CTDAtrazine results in increased expression of ESR1 proteinPMID:33766575
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDAtrazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; Atrazine inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 protein promotes the reaction [Atrazine results in increased expression of CCN2 protein]; ESR1 protein promotes the reaction [Atrazine results in increased expression of FOS protein]PMID:14579009 PMID:25616260 PMID:8858116
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