GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | increases activity | EXP | | 6480464 | CTD | Dichlorodiphenyl Dichloroethylene results in increased activity of ESR1 protein | PMID:17174995 PMID:9860891 | Esr1 | multiple interactions | EXP | | 6480464 | CTD | [o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR1 protein; [Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of ESR1 mRNA | PMID:34383603 PMID:9860891 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Dichlorodiphenyl Dichloroethylene binds to ESR1 protein; Dichlorodiphenyl Dichloroethylene metabolite binds to ESR1 protein | PMID:10492897 PMID:14579009 PMID:19913605 PMID:32278787 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Dichlorodiphenyl Dichloroethylene results in decreased expression of ESR1 mRNA | PMID:20206645 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Dichlorodiphenyl Dichloroethylene analog results in increased activity of ESR1 protein; Dichlorodiphenyl Dichloroethylene results in increased activity of ESR1 protein | PMID:15064155 PMID:18801367 PMID:26022396 | Esr1 | increases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Dichlorodiphenyl Dichloroethylene results in increased expression of ESR1 mRNA | PMID:21295777 | Esr1 | multiple interactions | ISO | Esr1 (Mus musculus) | 6480464 | CTD | [Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in increased expression of ESR1 mRNA | PMID:16758953 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Dichlorodiphenyl Dichloroethylene binds to and results in increased activity of ESR1 protein; Dichlorodiphenyl Dichloroethylene inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of ESR1 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Estradiol binds to ESR1 protein]; Fulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of ESR1 mRNA] | PMID:14579009 PMID:18275596 PMID:20206645 PMID:29162470 PMID:33049310 | |
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