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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581 Species: Rattus norvegicus RGD Object: Gene Symbol: Esr1 Name: estrogen receptor 1

Acc ID: CHEBI:1156 Term: 2-hydroxyestrone Definition: A 2-hydroxy steroid that has formula C18H22O3. CasRN: 362-06-1 Chemical ID: MESH:C024980

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects binding	ISO	RGD:736559	6480464	CTD	2-hydroxyestrone binds to ESR1 protein	PMID:16728493
multiple interactions	ISO	RGD:736559	6480464	CTD	2-hydroxyestrone binds to and results in increased activity of ESR1 protein	PMID:17713618