GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | increases expression | EXP | | 6480464 | CTD | Cadmium results in increased expression of ESR1 mRNA; Cadmium results in increased expression of ESR1 protein; Cadmium results in increased expression of ESR1 protein alternative form | PMID:24236210 | Esr1 | increases splicing | EXP | | 6480464 | CTD | Cadmium results in increased splicing of ESR1 mRNA | PMID:24236210 | Esr1 | multiple interactions | EXP | | 6480464 | CTD | Cadmium promotes the reaction [Estradiol results in increased expression of ESR1 mRNA]; Estradiol promotes the reaction [Cadmium results in increased expression of ESR1 mRNA] | PMID:24236210 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Cadmium results in decreased expression of ESR1 mRNA; Cadmium results in decreased expression of ESR1 protein | PMID:17125913 PMID:31646340 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Cadmium results in increased activity of ESR1 protein; Cadmium results in increased activity of ESR1 protein mutant form | PMID:16635015 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased ubiquitination of ESR1 protein; Cadmium binds to and affects the folding of ESR1 protein; Cadmium binds to and results in increased activity of ESR1 protein; Cadmium inhibits the reaction [Fulvestrant results in increased expression of ESR1 mRNA]; Cadmium promotes the reaction [[ESR1 protein binds to JUN protein binds to FOS protein] which binds to CXCL12 promoter]; Cadmium promotes the reaction [[ESR1 protein binds to JUN protein] which binds to CXCL12 promoter]; Cadmium promotes the reaction [ESR1 protein binds to CCND1 promoter]; Cadmium promotes the reaction [ESR1 protein binds to CXCL12 promoter]; Cadmium promotes the reaction [ESR1 protein binds to JUN protein binds to FOS protein]; Cadmium promotes the reaction [ESR1 protein binds to MYC promoter]; ESR1 mutant form inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; ESR1 mutant form inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; ESR1 protein affects the reaction [Cadmium results in increased expression of CXCL12 mRNA]; ESR1 protein affects the reaction [Cadmium results in increased expression of CXCL12 protein]; ESR1 protein alternative form affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of MMP2 protein]; ESR1 protein alternative form affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of MMP9 protein]; ESR1 protein results in increased susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]; Melatonin inhibits the reaction [Cadmium results in increased activity of ESR1 protein] | PMID:10770491 PMID:16635015 PMID:21829690 PMID:24015267 PMID:26006730 PMID:31468104 PMID:31646340 PMID:31689473 PMID:33040242 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |