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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:16548
Term: chlordecone
Definition: An organochlorine compound with insecticidal activity.
Chemical ID: MESH:D007631
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOEsr1 (Mus musculus)6480464CTDChlordecone binds to ESR1 proteinPMID:11162928 PMID:19913605
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDChlordecone binds to ESR1 proteinPMID:11162928 PMID:14579009 PMID:15253041 PMID:19913605 PMID:9751507
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDChlordecone results in increased activity of ESR1 protein mutant formPMID:17141713
Esr1increases expressionISOEsr1 (Mus musculus)6480464CTDChlordecone results in increased expression of ESR1 proteinPMID:17640991 PMID:29980752
Esr1multiple interactionsISOEsr1 (Mus musculus)6480464CTDChlordecone promotes the reaction [ESR1 protein binds to HSPA5 protein]; Chlordecone promotes the reaction [ESR1 protein binds to NLRC5 gene]; Chlordecone promotes the reaction [ESR1 protein binds to PIGO gene]; ESR1 protein affects the reaction [HSPA5 protein results in increased susceptibility to Chlordecone]PMID:17640991 PMID:29980752
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDChlordecone binds to and results in increased activity of ESR1 protein; Chlordecone inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 protein inhibits the reaction [Chlordecone results in increased expression of CCN5 mRNA]PMID:10774817 PMID:14579009 PMID:15026083 PMID:15253041 PMID:16626760 PMID:23384675 PMID:25012808 PMID:29162470 PMID:33049310 PMID:9751507
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