GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | affects binding | ISO | Esr1 (Mus musculus) | 6480464 | CTD | Chlordecone binds to ESR1 protein | PMID:11162928 PMID:19913605 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Chlordecone binds to ESR1 protein | PMID:11162928 PMID:14579009 PMID:15253041 PMID:19913605 PMID:9751507 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Chlordecone results in increased activity of ESR1 protein mutant form | PMID:17141713 | Esr1 | increases expression | ISO | Esr1 (Mus musculus) | 6480464 | CTD | Chlordecone results in increased expression of ESR1 protein | PMID:17640991 PMID:29980752 | Esr1 | multiple interactions | ISO | Esr1 (Mus musculus) | 6480464 | CTD | Chlordecone promotes the reaction [ESR1 protein binds to HSPA5 protein]; Chlordecone promotes the reaction [ESR1 protein binds to NLRC5 gene]; Chlordecone promotes the reaction [ESR1 protein binds to PIGO gene]; ESR1 protein affects the reaction [HSPA5 protein results in increased susceptibility to Chlordecone] | PMID:17640991 PMID:29980752 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Chlordecone binds to and results in increased activity of ESR1 protein; Chlordecone inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 protein inhibits the reaction [Chlordecone results in increased expression of CCN5 mRNA] | PMID:10774817 PMID:14579009 PMID:15026083 PMID:15253041 PMID:16626760 PMID:23384675 PMID:25012808 PMID:29162470 PMID:33049310 PMID:9751507 | |
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