GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | increases expression | EXP | | 6480464 | CTD | notoginsenoside R1 results in increased expression of ESR1; notoginsenoside R1 results in increased expression of ESR1 mRNA; notoginsenoside R1 results in increased expression of ESR1 protein | PMID:24720662 PMID:25738436 | Esr1 | increases expression | ISO | Esr1 (Mus musculus) | 6480464 | CTD | notoginsenoside R1 results in increased expression of ESR1 protein | PMID:23170834 | Esr1 | multiple interactions | ISO | Esr1 (Mus musculus) | 6480464 | CTD | [1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole results in decreased activity of ESR1 protein] which results in decreased susceptibility to notoginsenoside R1; [notoginsenoside R1 co-treated with Lipopolysaccharides] results in increased expression of ESR1 protein; fulvestrant inhibits the reaction [[notoginsenoside R1 co-treated with Lipopolysaccharides] results in increased expression of ESR1 protein] | PMID:23170834 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | notoginsenoside R1 results in increased phosphorylation of and results in increased activity of ESR1 protein | PMID:26362186 | |
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