Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of ESR1 mRNA; Arsenic Trioxide results in decreased expression of ESR1 proteinPMID:12014631 PMID:15283693 PMID:19088370
Esr1decreases methylationISOEsr1 (Mus musculus)6480464CTDArsenic Trioxide results in decreased methylation of ESR1 promoterPMID:15073043
Esr1decreases methylationISOESR1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased methylation of ESR1 gene; Arsenic Trioxide results in decreased methylation of ESR1 promoterPMID:21687957 PMID:23159075
Esr1increases expressionISOEsr1 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of ESR1 mRNA; Arsenic Trioxide results in increased expression of ESR1 proteinPMID:15073043 PMID:23159075
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTD[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA; [Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA; Arsenic Trioxide results in increased expression of ESR1 mRNA; Arsenic Trioxide results in increased expression of ESR1 proteinPMID:20458559 PMID:21687957 PMID:22558281 PMID:23159075
Esr1multiple interactionsISOEsr1 (Mus musculus)6480464CTD[Arsenic Trioxide co-treated with Tamoxifen] results in decreased methylation of ESR1 gene; [Arsenic Trioxide co-treated with Tamoxifen] results in increased expression of ESR1 mRNA; [Arsenic Trioxide co-treated with Tamoxifen] results in increased expression of ESR1 proteinPMID:23159075
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[Arsenic Trioxide results in decreased methylation of ESR1 promoter] which results in increased expression of ESR1 mRNA; [Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased susceptibility to Estradiol; afimoxifene inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; afimoxifene inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; Arsenic Trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]; Arsenic Trioxide promotes the reaction [Estradiol results in decreased expression of ESR1 mRNA]; Arsenic Trioxide promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; Estradiol promotes the reaction [Arsenic Trioxide results in decreased expression of ESR1 mRNA]; Estradiol promotes the reaction [Arsenic Trioxide results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide results in decreased methylation of ESR1 promoter]; S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide results in increased expression of ESR1 mRNA]; S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide results in increased expression of ESR1 protein]PMID:15283693 PMID:21687957 PMID:22558281
Go Back to source page   Continue to Ontology report