GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | decreases expression | EXP | | 6480464 | CTD | Melatonin results in decreased expression of ESR1 mRNA; Melatonin results in decreased expression of ESR1 protein | PMID:16051031 PMID:23591044 | Esr1 | multiple interactions | EXP | | 6480464 | CTD | [Ethanol co-treated with Melatonin] results in decreased expression of ESR1 protein; [Ethanol co-treated with Melatonin] results in increased expression of ESR1 protein; Melatonin promotes the reaction [alitretinoin results in decreased expression of ESR1 mRNA] | PMID:16051031 PMID:23591044 | Esr1 | decreases expression | ISO | Esr1 (Mus musculus) | 6480464 | CTD | Melatonin results in decreased expression of ESR1 mRNA | PMID:16030176 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Melatonin results in decreased expression of ESR1 mRNA | PMID:27551335 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Melatonin inhibits the reaction [Cadmium results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]] | PMID:15813899 PMID:16635015 PMID:26990689 PMID:27551335 | |
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