GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | affects binding | EXP | | 6480464 | CTD | Quercetin binds to ESR1 protein | PMID:19913605 | Esr1 | affects expression | EXP | | 6480464 | CTD | Quercetin affects the expression of ESR1 mRNA | PMID:32810592 | Esr1 | increases expression | EXP | | 6480464 | CTD | Quercetin results in increased expression of ESR1 mRNA | PMID:23200735 | Esr1 | multiple interactions | EXP | | 6480464 | CTD | [Quercetin co-treated with Bucladesine] results in increased expression of ESR1 mRNA; Quercetin affects the reaction [Doxorubicin affects the expression of ESR1 mRNA]; Quercetin promotes the reaction [Atrazine results in increased expression of ESR1 mRNA] | PMID:23200735 PMID:32810592 | Esr1 | affects activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Quercetin affects the activity of ESR1 protein | PMID:15185748 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Quercetin binds to ESR1 protein | PMID:14706564 PMID:19233257 PMID:19913605 | Esr1 | affects expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Quercetin affects the expression of ESR1 mRNA alternative form | PMID:32530119 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Quercetin results in decreased expression of ESR1 mRNA; Quercetin results in decreased expression of ESR1 protein | PMID:11502892 PMID:32530119 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Quercetin results in increased activity of ESR1 protein | PMID:16118406 PMID:22613215 | Esr1 | increases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Quercetin results in increased expression of ESR1 mRNA | PMID:36982678 | Esr1 | increases response to substance | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | ESR1 protein results in increased susceptibility to Quercetin | PMID:19194971 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [bisphenol A co-treated with Quercetin metabolite] results in increased expression of ESR1 mRNA; [bisphenol A co-treated with Quercetin] results in increased expression of ESR1 mRNA; [ESR1 protein results in increased susceptibility to Quercetin] which results in increased cleavage of CASP3 protein; [ESR1 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein; [Fulvestrant binds to and results in decreased activity of ESR1 protein] inhibits the reaction [Quercetin results in increased activity of ESR1 protein]; ESR1 protein affects the reaction [Quercetin results in increased secretion of APOA1 protein]; Estradiol affects the reaction [Quercetin results in increased activity of ESR1 protein]; Quercetin binds to and results in increased activity of ESR1 protein; Quercetin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Quercetin promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; SB 203580 inhibits the reaction [[ESR1 protein results in increased susceptibility to Quercetin] which results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[ESR1 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein]; Tamoxifen affects the reaction [Quercetin affects the expression of ESR1 mRNA alternative form]; Tamoxifen promotes the reaction [Quercetin results in decreased expression of ESR1 mRNA] | PMID:11502892 PMID:15182386 PMID:15937998 PMID:16118406 PMID:19194971 PMID:19233257 PMID:22613215 PMID:24963805 PMID:32530119 PMID:36982678 PMID:9751507 | | ||||||||||||||||||||||
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