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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581 Species: Rattus norvegicus RGD Object: Gene Symbol: Esr1 Name: estrogen receptor 1

Acc ID: CHEBI:16330 Term: 17beta-hydroxy-5alpha-androstan-3-one Definition: An androgen that has formula C19H30O2. CasRN: 521-18-6 Chemical ID: MESH:D013196

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:736559	6480464	CTD	Dihydrotestosterone binds to and results in increased activity of ESR1 protein	PMID:12676605
affects binding	ISO	RGD:736559	6480464	CTD	Dihydrotestosterone binds to ESR1 protein	PMID:11162928
affects binding	ISO	RGD:10551	6480464	CTD	Dihydrotestosterone binds to ESR1 protein	PMID:11162928
increases activity	EXP		6480464	CTD	Dihydrotestosterone results in increased activity of ESR1 protein	PMID:11750080
affects binding	ISO	RGD:736559	6480464	CTD	Dihydrotestosterone binds to ESR1 protein	PMID:11162928 PMID:19913605
affects binding	ISO	RGD:10551	6480464	CTD	Dihydrotestosterone binds to ESR1 protein	PMID:11162928 PMID:19913605
affects response to substance	ISO	RGD:10551	6480464	CTD	ESR1 protein affects the susceptibility to Dihydrotestosterone	PMID:22275727
multiple interactions	ISO	RGD:736559	6480464	CTD	Dihydrotestosterone inhibits the reaction [Estradiol binds to ESR1 protein]	PMID:19022364
multiple interactions	ISO	RGD:736559	6480464	CTD	Dichlorodiphenyl Dichloroethylene inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of ESR1 protein] hydroxyflutamide inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of ESR1 protein]	PMID:18275596