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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:16330
Term: 17beta-hydroxy-5alpha-androstan-3-one
Definition: A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.
Chemical ID: MESH:D013196
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases activityEXP 6480464CTDDihydrotestosterone results in increased activity of ESR1 proteinPMID:11750080
Esr1affects bindingISOEsr1 (Mus musculus)6480464CTDDihydrotestosterone binds to ESR1 proteinPMID:11162928 PMID:19913605
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDDihydrotestosterone binds to ESR1 proteinPMID:11162928 PMID:19913605
Esr1affects response to substanceISOEsr1 (Mus musculus)6480464CTDESR1 protein affects the susceptibility to DihydrotestosteronePMID:22275727
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDDihydrotestosterone results in increased expression of ESR1 protein alternative formPMID:25969534
Esr1increases phosphorylationISOESR1 (Homo sapiens)6480464CTDDihydrotestosterone results in increased phosphorylation of ESR1 proteinPMID:25969534
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of ESR1 protein; Dichlorodiphenyl Dichloroethylene inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of ESR1 protein]; Dihydrotestosterone binds to and results in increased activity of ESR1 protein; Dihydrotestosterone inhibits the reaction [Estradiol binds to ESR1 protein]; hydroxyflutamide inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of ESR1 protein]PMID:12676605 PMID:18275596 PMID:19022364 PMID:29162470
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