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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:6784
Term: mestranol
Definition: A terminal acetylenic compound that is (17alpha)-17-ethynylestra-1(10),2,4-triene substituted by a methoxy group at position 3 and a hydroxy group at position 17.
Chemical ID: MESH:D008656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDMestranol results in increased activity of ESR1 proteinPMID:12623674
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDESR1 protein affects the reaction [Mestranol results in increased expression of GREB1 mRNA]; ESR1 protein affects the reaction [Mestranol results in increased expression of SGK1 mRNA]; Mestranol binds to and results in increased activity of ESR1 proteinPMID:26865669 PMID:33049310 PMID:33405908
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