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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:34911
Term: permethrin
Definition: A cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups.
Chemical ID: MESH:D026023
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingEXP 6480464CTDPermethrin binds to ESR1 proteinPMID:12396874
Esr1decreases activityEXP 6480464CTDPermethrin results in decreased activity of ESR1 proteinPMID:20410157
Esr1increases activityEXP 6480464CTDPermethrin results in increased activity of ESR1 proteinPMID:20410157
Esr1increases expressionEXP 6480464CTDPermethrin results in increased expression of ESR1 mRNAPMID:24388911
Esr1multiple interactionsEXP 6480464CTD[Permethrin co-treated with Estradiol] results in decreased expression of ESR1PMID:25048945
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDPermethrin binds to ESR1 protein; Permethrin metabolite binds to ESR1 proteinPMID:20574910 PMID:32278787
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDPermethrin results in decreased expression of ESR1 mRNAPMID:20397420
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDPermethrin results in increased activity of ESR1 proteinPMID:15064155
Esr1increases expressionISOEsr1 (Mus musculus)6480464CTDPermethrin metabolite results in increased expression of ESR1 mRNAPMID:20574910
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDPermethrin results in increased expression of ESR1 mRNAPMID:24388911
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDPermethrin binds to and results in increased activity of ESR1 protein; Permethrin metabolite binds to and results in increased activity of ESR1 proteinPMID:16395479 PMID:33049310
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