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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:pulmonary hypertension
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Accession:DOID:6432 term browser browse the term
Definition:A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries. (DO)
Synonyms:exact_synonym: PHT
 narrow_synonym: PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED;   primary pulmonary hypertension, fenfluramine-associated
 primary_id: MESH:D006976
 xref: EFO:0001361;   ICD10CM:I27.20;   NCI:C3120
For additional species annotation, visit the Alliance of Genome Resources.

GViewer not supported for the selected species.

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pulmonary hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca3 ATP binding cassette subfamily A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26780485 NCBI chrNW_004936694:1,735,206...1,778,100
Ensembl chrNW_004936694:1,736,207...1,778,116 		JBrowse link
G Ace2 angiotensin converting enzyme 2 treatment ISO CTD Direct Evidence: therapeutic
human protein in a rat model		 CTD
RGD		 PMID:25225206 PMID:31931441 RGD:40818280 NCBI chrNW_004936470:4,964,526...5,011,808
Ensembl chrNW_004936470:4,965,332...5,011,702 		JBrowse link
G Acvrl1 activin A receptor like type 1 susceptibility
disease_progression		 ISO associated with hereditary haemorrhagic telangiectasia;DNA:missense mutations
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung
DNA:mutations (human)		 RGD
CTD		 PMID:14684682 PMID:17392319 PMID:20056902 PMID:26540443 RGD:1601116 RGD:1601117 RGD:5128837 NCBI chrNW_004936512:9,364,551...9,379,131
Ensembl chrNW_004936512:9,364,149...9,379,431 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO RGD PMID:19168697 RGD:5686821 NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928 		JBrowse link
G Adm adrenomedullin ISO RGD PMID:14718403 RGD:1625305 NCBI chrNW_004936528:8,005,223...8,007,586
Ensembl chrNW_004936528:8,005,189...8,007,643 		JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO protein:increased expression:lung (human) RGD PMID:21041689 RGD:7244258 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G Agt angiotensinogen ISO RGD PMID:21381494 RGD:5129162 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
G Agtr1 angiotensin II receptor type 1 onset ISO DNA:polymorphism:3' utr:1166A>C (human) RGD PMID:19332265 RGD:5147450 NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985 		JBrowse link
G Ahr aryl hydrocarbon receptor ameliorates ISO 6-formylindolo[3,2-b]carbazole (FICZ)|semaxanib (CHEBI:91083)
compared to wild type littermates		 RGD PMID:33836606 RGD:401940192 NCBI chrNW_004936546:3,737,908...3,783,492
Ensembl chrNW_004936546:3,737,851...3,783,588 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 ISO mRNA:increased expression:lung (rat) RGD PMID:16181105 RGD:4144185 NCBI chrNW_004936529:3,518,337...3,531,842
Ensembl chrNW_004936529:3,518,322...3,531,845 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase treatment ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:artery		 CTD
RGD		 PMID:8647941 PMID:9445303 PMID:14726295 PMID:31462075 RGD:14975304 RGD:1626154 RGD:4890418 RGD:734558 NCBI chrNW_004936554:7,807,914...7,848,691
Ensembl chrNW_004936554:7,808,355...7,867,931 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein ISO protein:increased expression:artery RGD PMID:8647941 PMID:9445303 RGD:1626154 RGD:734558 NCBI chrNW_004936472:25,477,094...25,502,823
Ensembl chrNW_004936472:25,477,010...25,502,840 		JBrowse link
G Angpt1 angiopoietin 1 ISO protein:decreased expression:pulmonary artery RGD PMID:18073453 RGD:2316069 NCBI chrNW_004936470:37,105,469...37,328,183
Ensembl chrNW_004936470:37,105,466...37,328,190 		JBrowse link
G Angpt2 angiopoietin 2 ISO protein:increased expression:pulmonary artery (rat) RGD PMID:19712575 RGD:2314185 NCBI chrNW_004936615:4,472,261...4,524,537
Ensembl chrNW_004936615:4,472,247...4,524,556 		JBrowse link
G Apln apelin ISO protein:decreased expression:plasma RGD PMID:16263185 RGD:1626175 NCBI chrNW_004936479:1,889,930...1,899,811
Ensembl chrNW_004936479:1,890,229...1,899,730 		JBrowse link
G Arg2 arginase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24951775 NCBI chrNW_004936495:11,004,296...11,045,467
Ensembl chrNW_004936495:11,004,176...11,045,472 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 treatment ISO RGD PMID:23804254 PMID:27144451 RGD:13782086 RGD:13782089 NCBI chrNW_004936558:3,300,941...3,357,595
Ensembl chrNW_004936558:3,300,941...3,357,941 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha treatment ISO chronic thromboembolic pulmonary hypertension RGD PMID:21396162 RGD:13703061 NCBI chrNW_004936517:743,036...752,836
Ensembl chrNW_004936517:742,791...753,336 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 treatment ISO mRNA, protein:increased expression:lung, plasma (rat) RGD PMID:27491388 PMID:27916219 RGD:13800892 RGD:13800894 NCBI chrNW_004936640:1,916,711...1,924,823 JBrowse link
G Atp7a ATPase copper transporting alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:24614111 NCBI chrNW_004936683:2,874,022...2,936,214
Ensembl chrNW_004936683:2,874,042...2,935,040 		JBrowse link
G Bcl2 BCL2 apoptosis regulator ISO protein:decreased expression:heart right ventricle RGD PMID:18441466 RGD:2293022 NCBI chrNW_004936497:2,209,136...2,373,580
Ensembl chrNW_004936497:2,210,334...2,210,921 		JBrowse link
G Bcl2l1 BCL2 like 1 treatment ISO RGD PMID:22559233 RGD:10400914 NCBI chrNW_004936485:18,654,046...18,707,324 JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO RGD PMID:15878794 RGD:4890453 NCBI chrNW_004936604:548,844...551,031
Ensembl chrNW_004936604:548,847...549,956 		JBrowse link
G Birc5 baculoviral IAP repeat containing 5 ISO protein:increased expression:pulmonary artery RGD PMID:15931388 RGD:2293135 NCBI chrNW_004936594:2,812,165...2,820,618
Ensembl chrNW_004936594:2,812,238...2,820,636 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A ISO RGD PMID:19324947 RGD:5129472 NCBI chrNW_004936804:52,435...115,289
Ensembl chrNW_004936804:48,947...115,412 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B ISO RGD PMID:19324947 RGD:5129472 NCBI chrNW_004936687:2,346,601...2,595,283
Ensembl chrNW_004936687:2,503,777...2,597,522 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 treatment
disease_progression		 ISO CTD Direct Evidence: marker/mechanism
induced by human ad-ALOX5
protein:decreased expression:lung
DNA:missense mutations (human)
DNA:mutations: :multiple (human)		 CTD
RGD		 PMID:11590841 PMID:11893684 PMID:12358323 PMID:15775752 PMID:16297860 More... RGD:14975304 RGD:1580076 RGD:38500243 RGD:38500244 RGD:5129237 RGD:5129238 RGD:5129239 RGD:5129472 RGD:5129474 NCBI chrNW_004936726:1,543,263...1,711,422
Ensembl chrNW_004936726:1,543,245...1,704,541 		JBrowse link
G Brd4 bromodomain containing 4 ISO CTD Direct Evidence: therapeutic CTD PMID:26224795 NCBI chrNW_004936596:5,176,682...5,246,102
Ensembl chrNW_004936596:5,177,147...5,246,518 		JBrowse link
G Ca9 carbonic anhydrase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20110409 NCBI chrNW_004936524:3,672,393...3,678,630
Ensembl chrNW_004936524:3,672,541...3,678,433 		JBrowse link
G Calca calcitonin related polypeptide alpha ISO CTD Direct Evidence: therapeutic CTD PMID:1357980 NCBI chrNW_004936528:3,800,801...3,806,000
Ensembl chrNW_004936528:3,800,577...3,805,004 		JBrowse link
G Casr calcium sensing receptor ISO protein:increased expression:pulmonary artery (rat) RGD PMID:22730443 RGD:7205669 NCBI chrNW_004936536:8,574,064...8,599,446
Ensembl chrNW_004936536:8,574,064...8,599,454 		JBrowse link
G Cav1 caveolin 1 treatment ISO idiopathic pulmonary arterial hypertension (IPAH) RGD PMID:15353500 PMID:17470567 PMID:23538027 RGD:1581153 RGD:1625360 RGD:8662276 NCBI chrNW_004936589:2,504,235...2,536,778
Ensembl chrNW_004936589:2,504,224...2,537,170 		JBrowse link
G Cavin1 caveolae associated protein 1 ISO OMIM:615371 MouseDO NCBI chrNW_004936490:17,197,585...17,200,041 JBrowse link
G Cbln2 cerebellin 2 precursor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23502781 NCBI chrNW_004936756:567,906...576,276
Ensembl chrNW_004936756:567,710...575,205 		JBrowse link
G Ccl1 C-C motif chemokine ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22507635 NCBI chrNW_004936538:781,687...784,199
Ensembl chrNW_004936538:781,687...784,199 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:serum (human) RGD PMID:19932032 RGD:4891440 NCBI chrNW_004936490:253,279...259,947
Ensembl chrNW_004936490:253,034...259,965 		JBrowse link
G Ccn2 cellular communication network factor 2 ISO protein:increased expression:pulmonary artery (rat) RGD PMID:19234054 RGD:2314535 NCBI chrNW_004936560:42,561...45,748
Ensembl chrNW_004936560:42,537...45,807 		JBrowse link
G Cd28 CD28 molecule ISO RGD PMID:19075187 RGD:5131619 NCBI chrNW_004936631:335,411...363,407
Ensembl chrNW_004936631:335,411...363,407 		JBrowse link
G Cd40 CD40 molecule treatment ISO RGD PMID:25998782 RGD:11344970 NCBI chrNW_004936514:6,936,915...6,947,246
Ensembl chrNW_004936514:6,936,572...6,947,280 		JBrowse link
G Cd40lg CD40 ligand ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum (rat)		 CTD
RGD		 PMID:15302794 PMID:25998782 RGD:11344970 NCBI chrNW_004936513:10,607,617...10,620,403
Ensembl chrNW_004936513:10,607,617...10,620,403 		JBrowse link
G Cd86 CD86 molecule ISO protein:decreased expression:blood, myeloid dendritic cell (human) RGD PMID:19693657 RGD:4892293 NCBI chrNW_004936536:8,414,491...8,481,712 JBrowse link
G Cdh5 cadherin 5 ISO protein:decreased expression:lung RGD PMID:25593290 RGD:38500244 NCBI chrNW_004936475:16,738,772...16,775,000
Ensembl chrNW_004936475:16,738,748...16,775,123 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A treatment ISO RGD PMID:24334871 PMID:24412385 RGD:10043360 RGD:10043361 NCBI chrNW_004936476:22,717,308...22,725,127
Ensembl chrNW_004936476:22,717,260...22,725,182 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B treatment ISO RGD PMID:22383500 RGD:10045357 NCBI chrNW_004936587:4,573,166...4,578,480
Ensembl chrNW_004936587:4,572,728...4,578,461 		JBrowse link
G Clu clusterin ISO RGD PMID:25069740 RGD:9068424 NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836 		JBrowse link
G Col1a1 collagen type I alpha 1 chain treatment ISO RGD PMID:25867313 RGD:11041577 NCBI chrNW_004936490:11,448,552...11,465,836
Ensembl chrNW_004936490:11,448,654...11,464,444 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain treatment ISO RGD PMID:25867313 RGD:11041577 NCBI chrNW_004936472:2,416,043...2,543,561
Ensembl chrNW_004936472:2,416,566...2,542,814 		JBrowse link
G Crp C-reactive protein ISO associated with Pulmonary Disease, Chronic Obstructive RGD PMID:22333502 RGD:6482312 NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:12524378 PMID:17186992 RGD:11039432 RGD:11039539 NCBI chrNW_004936490:15,142,526...15,146,375
Ensembl chrNW_004936490:15,142,808...15,144,487 		JBrowse link
G Ctnnd1 catenin delta 1 treatment ISO RGD PMID:25593290 RGD:38500244 NCBI chrNW_004936581:4,750,845...4,802,262
Ensembl chrNW_004936581:4,750,947...4,802,289 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO mRNA, protein:increased expression:lung
associated with Heart Defects, Congenital		 RGD PMID:18630689 PMID:19948918 PMID:20869263 RGD:4891883 RGD:4891887 RGD:4891889 NCBI chrNW_004936475:9,443,851...9,454,715
Ensembl chrNW_004936475:9,443,733...9,455,062 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO mRNA, protein:increased expression:lung
associated with Scleroderma, Systemic;DNA:polymorphisms: :p.V249I, p.T280M (human)		 RGD PMID:16584113 PMID:17182651 RGD:4891893 RGD:4891896 NCBI chrNW_004936473:28,508,726...28,535,640
Ensembl chrNW_004936473:28,510,523...28,535,627 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 treatment ISO RGD PMID:21294880 RGD:6480473 NCBI chrNW_004936469:39,794,613...39,798,448
Ensembl chrNW_004936469:39,794,584...39,798,459 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 ISO associated with Anoxia RGD PMID:12910720 RGD:4848274 NCBI chrNW_004936547:479,261...504,757 JBrowse link
G Dll4 delta like canonical Notch ligand 4 ISO RGD PMID:34739767 RGD:155646132 NCBI chrNW_004936471:4,320,235...4,330,251
Ensembl chrNW_004936471:4,320,933...4,330,253 		JBrowse link
G Ece1 endothelin converting enzyme 1 ISO associated with Anoxia; RGD PMID:18767389 RGD:7243939 NCBI chrNW_004936474:7,034,134...7,083,005
Ensembl chrNW_004936474:7,034,134...7,083,005 		JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism
associated with Pulmonary Disease, Chronic Obstructive; protein:increased secretion:plasma (human)
mRNA:increased expression:lung (rat)
Hypertension, Heritable Pulmonary Artery; mRNA:increased expression:bone marrow, macrophage (mouse)
Hypertension, Portopulmonary; protein:increased secretion:plasma (human)		 CTD
RGD		 PMID:7549228 PMID:9918753 PMID:12391278 PMID:20498147 PMID:20562228 More... RGD:4144128 RGD:4144865 RGD:4144877 RGD:4144882 NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772 		JBrowse link
G Edn2 endothelin 2 ISO RGD PMID:10598486 RGD:1580918 NCBI chrNW_004936474:23,061,219...23,064,525
Ensembl chrNW_004936474:23,060,905...23,064,566 		JBrowse link
G Ednra endothelin receptor type A ISO RGD PMID:15243299 PMID:18506008 PMID:20531217 PMID:20562228 RGD:1580949 RGD:4144877 RGD:4892283 RGD:4892320 NCBI chrNW_004936535:1,950,117...2,005,786
Ensembl chrNW_004936535:1,949,941...2,005,910 		JBrowse link
G Ednrb endothelin receptor type B ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:15243299 PMID:15927975 PMID:18091567 PMID:20562228 RGD:1580949 RGD:4144877 RGD:4892289 NCBI chrNW_004936511:3,446,864...3,478,434
Ensembl chrNW_004936511:3,446,839...3,478,434 		JBrowse link
G Egfr epidermal growth factor receptor ISO protein:increased expression:lung, arteriole (human) RGD PMID:12896876 PMID:21492463 RGD:5131626 RGD:5131639 NCBI chrNW_004936678:365,005...560,546
Ensembl chrNW_004936678:365,834...436,528 		JBrowse link
G Egr1 early growth response 1 ISO protein:increased expression:lung (human)
mRNA, protein:increased expression:lung (rat)
mRNA, protein:increased expression:lung (mouse)		 RGD PMID:18599502 PMID:20023177 PMID:20889906 PMID:21924231 RGD:10395308 RGD:5131875 RGD:5131883 RGD:5131890 NCBI chrNW_004936531:7,625,956...7,629,041
Ensembl chrNW_004936531:7,625,892...7,629,749 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24292273 NCBI chrNW_004936471:3,423,792...3,527,089
Ensembl chrNW_004936471:3,423,813...3,526,913 		JBrowse link
G Eng endoglin ISO RGD PMID:20042709 RGD:11041178 NCBI chrNW_004936487:15,467,165...15,499,180
Ensembl chrNW_004936487:15,467,835...15,477,488 		JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO DNA:missense mutation:cds: 2097G>A,p.G537R(human) RGD PMID:16215633 PMID:18650473 RGD:10395375 RGD:11041573 NCBI chrNW_004936508:5,855,748...5,938,879
Ensembl chrNW_004936508:5,855,732...5,938,856 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO RGD PMID:19226702 RGD:5688731 NCBI chrNW_004936675:350,357...392,919
Ensembl chrNW_004936675:350,342...392,551 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:22559233 RGD:10400914 NCBI chrNW_004936543:742,722...745,332
Ensembl chrNW_004936543:743,537...745,343 		JBrowse link
G Esr1 estrogen receptor 1 ISO RGD PMID:20081107 RGD:4892253 NCBI chrNW_004936489:4,616,839...4,887,179
Ensembl chrNW_004936489:4,614,754...4,887,171 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:21700911 RGD:5508791 NCBI chrNW_004936495:7,956,168...8,018,356
Ensembl chrNW_004936495:7,956,766...8,004,357 		JBrowse link
G F5 coagulation factor V ISO Chronic thromboembolic pulmonary hypertension (CTEPH) RGD PMID:20182352 RGD:4892669 NCBI chrNW_004936481:17,114,441...17,178,902
Ensembl chrNW_004936481:17,114,480...17,178,844 		JBrowse link
G Fbln5 fibulin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12189163 NCBI chrNW_004936733:136,374...200,106
Ensembl chrNW_004936733:137,207...209,473 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO RGD PMID:19197140 RGD:2315911 NCBI chrNW_004936710:1,760,365...1,815,269
Ensembl chrNW_004936710:1,760,089...1,815,508 		JBrowse link
G Foxo1 forkhead box O1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27663689 NCBI chrNW_004936565:5,210,014...5,299,213
Ensembl chrNW_004936565:5,210,014...5,302,436 		JBrowse link
G Gata4 GATA binding protein 4 ISO protein:increased expression:heart right ventricle RGD PMID:21059997 RGD:7207053 NCBI chrNW_004936675:3,408,549...3,420,828 JBrowse link
G Gata6 GATA binding protein 6 ISO mRNA, protein:decreased expression:lung
protein:decreased expression:lung, arteriole, venule (human)		 RGD PMID:19842842 PMID:23583651 RGD:13208869 RGD:2314194 NCBI chrNW_004936550:1,814,336...1,844,399
Ensembl chrNW_004936550:1,814,336...1,844,399 		JBrowse link
G Gba1 glucosylceramidase beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12359135 NCBI chrNW_004936580:4,715,869...4,720,752
Ensembl chrNW_004936580:4,715,408...4,720,798 		JBrowse link
G Gdf2 growth differentiation factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26801773 NCBI chrNW_004936554:7,307,461...7,322,048
Ensembl chrNW_004936554:7,316,435...7,322,060 		JBrowse link
G Gja1 gap junction protein alpha 1 treatment ISO mRNA:increased expression:pulmonary artery RGD PMID:21414209 PMID:23321332 RGD:7207411 RGD:8662411 NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987 		JBrowse link
G Gpr182 G protein-coupled receptor 182 ISO mRNA:increased expression:lung RGD PMID:12622928 RGD:1625768 NCBI chrNW_004936646:1,210,711...1,212,746
Ensembl chrNW_004936646:1,210,757...1,212,425 		JBrowse link
G Has1 hyaluronan synthase 1 ISO RGD PMID:19915162 RGD:9588633 NCBI chrNW_004937026:125,622...132,141
Ensembl chrNW_004937026:125,881...135,235 		JBrowse link
G Has2 hyaluronan synthase 2 ISO mRNA:increased expression:lung RGD PMID:19915162 RGD:9588633 NCBI chrNW_004936470:25,418,069...25,443,332
Ensembl chrNW_004936470:25,418,063...25,444,634 		JBrowse link
G Has3 hyaluronan synthase 3 ISO mRNA:decreased expression:lung RGD PMID:19915162 RGD:9588633 NCBI chrNW_004936475:19,270,788...19,282,922
Ensembl chrNW_004936475:19,270,830...19,282,907 		JBrowse link
G Hdac1 histone deacetylase 1 ISO protein:increased expression:lung: RGD PMID:22711276 RGD:9590133 NCBI chrNW_004936474:15,320,635...15,351,418
Ensembl chrNW_004936474:15,320,729...15,350,860 		JBrowse link
G Hdac2 histone deacetylase 2 ISO protein:decreased expression:lung: RGD PMID:22711276 RGD:9590133 NCBI chrNW_004936679:2,448,676...2,474,641
Ensembl chrNW_004936679:2,448,390...2,474,641 		JBrowse link
G Hdac3 histone deacetylase 3 ISO protein:decreased expression:lung: RGD PMID:22711276 RGD:9590133 NCBI chrNW_004936504:12,530,546...12,546,556
Ensembl chrNW_004936504:12,530,528...12,546,556 		JBrowse link
G Hdac4 histone deacetylase 4 ISO protein:increased expression:lung: RGD PMID:22711276 RGD:9590133 NCBI chrNW_004936745:1,730,743...1,942,071
Ensembl chrNW_004936745:1,730,694...1,942,074 		JBrowse link
G Hdac5 histone deacetylase 5 ISO protein:increased expression:lung: RGD PMID:22711276 RGD:9590133 NCBI chrNW_004936541:561,721...598,915
Ensembl chrNW_004936541:558,414...599,195 		JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 ISO mRNA:decreased expression:lung: RGD PMID:34739767 RGD:155646132 NCBI chrNW_004936871:666,961...670,910
Ensembl chrNW_004936871:666,938...670,916 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO CTD Direct Evidence: marker/mechanism
associated with Anoxia;protein:increased expression:pulmonary artery		 CTD
RGD		 PMID:16215633 PMID:17213961 PMID:20110409 RGD:10395375 RGD:1601553 NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157 		JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha ISO RGD PMID:16215633 RGD:10395375 NCBI chrNW_004936664:296,288...323,143
Ensembl chrNW_004936664:294,975...323,149 		JBrowse link
G Hk1 hexokinase 1 ISO mRNA:increased expression:lung RGD PMID:25767292 RGD:11353880 NCBI chrNW_004936521:9,067,062...9,139,112
Ensembl chrNW_004936521:9,066,999...9,159,793 		JBrowse link
G Hmgb1 high mobility group box 1 treatment ISO RGD PMID:25032709 RGD:10402082 NCBI chrNW_004936472:25,236,728...25,246,585
Ensembl chrNW_004936472:25,236,728...25,246,580 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:12750068 RGD:5508701 NCBI chrNW_004936549:1,378,536...1,400,501
Ensembl chrNW_004936549:1,378,736...1,400,532 		JBrowse link
G Hmox1 heme oxygenase 1 ISO RGD PMID:14970910 PMID:19409105 PMID:20957739 RGD:1582715 RGD:4145307 RGD:4145325 NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase ISO mRNA, protein:increased expression:lung RGD PMID:24657469 RGD:11667099 NCBI chrNW_004936516:5,551,192...5,578,796
Ensembl chrNW_004936516:5,550,203...5,578,832 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ameliorates ISO RGD PMID:28473438 RGD:329955562 NCBI chrNW_004936890:154,252...157,044
Ensembl chrNW_004936890:155,233...156,408 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:14659797 NCBI chrNW_004936525:5,711,894...5,729,074
Ensembl chrNW_004936525:5,712,329...5,729,831 		JBrowse link
G Hyal1 hyaluronidase 1 ISO mRNA:decreased expression:lung RGD PMID:19915162 RGD:9588633 NCBI chrNW_004936529:1,838,212...1,842,399
Ensembl chrNW_004936529:1,838,676...1,841,188 		JBrowse link
G Hyal2 hyaluronidase 2 ISO mRNA:decreased expression:lung RGD PMID:19915162 RGD:9588633 NCBI chrNW_004936529:1,845,445...1,851,106
Ensembl chrNW_004936529:1,845,763...1,851,252 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO associated with Heart Defects, Congenital;protein:increased secretion:serum (human) RGD PMID:21034646 RGD:4145436 NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein ISO RGD PMID:20522807 RGD:9686087 NCBI chrNW_004936485:18,610,721...18,611,889
Ensembl chrNW_004936485:18,610,665...18,612,059 		JBrowse link
G Ifngr1 interferon gamma receptor 1 ISO mRNA: increased expression RGD PMID:20808962 RGD:4892610 NCBI chrNW_004936560:4,519,858...4,545,763
Ensembl chrNW_004936560:4,519,474...4,545,796 		JBrowse link
G Il10 interleukin 10 disease_progression ISO protein:increased expression:serum RGD PMID:20713898 RGD:4142530 NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502 		JBrowse link
G Il13 interleukin 13 ISO associated with Scleroderma, Limited;protein:increased expression:plasma
associated with sclerosis; protein:increased expression:plasma (human)		 RGD PMID:19799786 PMID:21425123 RGD:4145600 RGD:8549528 NCBI chrNW_004936647:2,529,933...2,532,503
Ensembl chrNW_004936647:2,530,491...2,532,373 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 ISO RGD PMID:20671265 PMID:20808962 RGD:4892610 RGD:4892611 NCBI chrNW_004936479:11,052,077...11,108,915
Ensembl chrNW_004936479:11,050,249...11,108,909 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 ISO mRNA:increased expression:lung RGD PMID:20522789 RGD:4892612 NCBI chrNW_004936499:860,179...883,884
Ensembl chrNW_004936499:863,599...883,855 		JBrowse link
G Il18 interleukin 18 ISO RGD PMID:17400729 RGD:4889590 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:serum
associated with Scleroderma, Limited;protein:increased expression:serum		 RGD PMID:20713898 PMID:20808962 RGD:4142530 RGD:4892610 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO RGD PMID:7946395 RGD:4143197 NCBI chrNW_004936783:1,447,158...1,466,331
Ensembl chrNW_004936783:1,447,106...1,466,340 		JBrowse link
G Il23r interleukin 23 receptor ISO associated with Scleroderma, Systemic;DNA:SNPs: :rs11209026, rs11465804 (human) RGD PMID:19918037 RGD:5096624 NCBI chrNW_004936591:4,365,598...4,425,053
Ensembl chrNW_004936591:4,365,762...4,425,005 		JBrowse link
G Il6 interleukin 6 disease_progression ISO RGD PMID:20693255 PMID:20713898 RGD:4142530 RGD:4143246 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 severity ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:30365877 PMID:31347976 RGD:151347452 NCBI chrNW_004936493:5,767,779...5,772,043
Ensembl chrNW_004936493:5,770,103...5,772,326 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28090300 NCBI chrNW_004936521:2,000,113...2,706,010
Ensembl chrNW_004936521:2,000,109...2,705,365 		JBrowse link
G Kdm5b lysine demethylase 5B ISO associated with Hypoxia;protein:increased expression:pulmonary artery,smooth muscle tissue (mouse) RGD PMID:30172777 RGD:329955443 NCBI chrNW_004936567:1,782,056...1,860,861
Ensembl chrNW_004936567:1,781,995...1,863,461 		JBrowse link
G Lcn2 lipocalin 2 ISO associated with congenital heart disease; protein:increased expression:plasma
mRNA,protein:increased expression:lung		 RGD PMID:25076856 RGD:126781744 NCBI chrNW_004936487:15,721,752...15,725,396
Ensembl chrNW_004936487:15,721,684...15,728,221 		JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:30689673 NCBI chrNW_004936591:5,771,371...5,846,177
Ensembl chrNW_004936591:5,774,326...5,836,444 		JBrowse link
G LOC101964975 interleukin-8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15302794 NCBI chrNW_004936598:1,779,471...1,781,353
Ensembl chrNW_004936598:1,779,471...1,781,353 		JBrowse link
G LOC101966992 cytochrome b-245 heavy chain treatment ISO associated with Anoxia RGD PMID:18424632 PMID:18952568 RGD:4762683 RGD:4773907 NCBI chrNW_004936502:4,631,750...4,676,686
Ensembl chrNW_004936502:4,635,149...4,676,904 		JBrowse link
G LOC101967032 cytochrome b-245 light chain ISO associated with Anoxia;mRNA, protein:increased expression:lung RGD PMID:18424632 PMID:18952568 RGD:4762683 RGD:4773907 NCBI chrNW_004936641:1,036,967...1,044,954
Ensembl chrNW_004936641:1,036,967...1,044,991 		JBrowse link
G LOC101968921 angiotensin-converting enzyme ISO CTD Direct Evidence: marker/mechanism CTD PMID:12359135 NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177 		JBrowse link
G LOC101969148 cytochrome P450 1A1 ISO mRNA,protein:increased expression:lung RGD PMID:28956952 RGD:13702097 NCBI chrNW_004936471:33,682,730...33,688,332
Ensembl chrNW_004936471:33,682,730...33,688,332 		JBrowse link
G LOC101976500 haptoglobin treatment ISO protein:decreased expression:serum RGD PMID:2043024 PMID:19023114 PMID:19703762 PMID:25656991 RGD:11041794 RGD:1626353 RGD:5147420 RGD:5147440 NCBI chrNW_004936475:21,841,054...21,845,821 JBrowse link
G LOC101976824 nuclear factor of activated T cells 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17596340 PMID:27522126 RGD:1627651 NCBI chrNW_004936514:3,453,475...3,579,292
Ensembl chrNW_004936514:3,467,178...3,578,882 		JBrowse link
G Lox lysyl oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24614111 NCBI chrNW_004936575:2,526,067...2,533,996
Ensembl chrNW_004936575:2,524,342...2,533,559 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 treatment ISO RGD PMID:25907942 RGD:13800893 NCBI chrNW_004936619:1,889,841...1,932,646
Ensembl chrNW_004936619:1,889,708...1,932,646 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 treatment ISO RGD PMID:25907942 RGD:13800893 NCBI chrNW_004936501:12,342,670...12,390,650
Ensembl chrNW_004936501:12,384,804...12,392,180 		JBrowse link
G Mfn1 mitofusin 1 ISO protein:decreased expression:heart right ventricle (rat) RGD PMID:27422986 RGD:12910832 NCBI chrNW_004936566:3,737,315...3,775,894
Ensembl chrNW_004936566:3,737,315...3,775,693 		JBrowse link
G Mif macrophage migration inhibitory factor ISO associated with sclerodema, systemic; protein:increased expression:serum RGD PMID:18618071 RGD:4891006 NCBI chrNW_004936619:1,207,058...1,208,010
Ensembl chrNW_004936619:1,203,746...1,208,442 		JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO RGD PMID:23087098 RGD:7207217 NCBI chrNW_004936551:5,167,909...5,175,149
Ensembl chrNW_004936551:5,168,044...5,174,857 		JBrowse link
G Mmp9 matrix metallopeptidase 9 severity ISO associated with Heart Failure, Congestive;protein:decreased expression:monocyte
associated with Pulmonary Embolism;protein:increased expression:lung, plasma		 RGD PMID:16867026 PMID:17133179 PMID:18355767 PMID:21063214 PMID:23087098 RGD:1642028 RGD:1642053 RGD:5129210 RGD:5130155 RGD:7207217 NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:23470622 RGD:10041039 NCBI chrNW_004936474:158,376...282,310
Ensembl chrNW_004936474:157,590...282,342 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor treatment ISO RGD PMID:22306243 RGD:7240564 NCBI chrNW_004936470:20,480,844...20,485,955
Ensembl chrNW_004936470:20,480,829...20,485,965 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase susceptibility ISO mRNA,protein:increased expression:lung,pulmonary arterial endothelial cell:
protein:increased expression:lung:		 RGD PMID:28202489 RGD:13781882 NCBI chrNW_004936479:17,682,070...17,716,713
Ensembl chrNW_004936479:17,682,201...17,716,661 		JBrowse link
G Nos2 nitric oxide synthase 2 onset ISO associated with heart disease; protein:increased expression:endothelial cell
associated with Congenital diaphragmatic hernia; protein:decreased expression:pulmonary artery, endothelium
associated with Anoxia; mouse gene in rat model
associated with Anoxia; protein:increased expression:pulmonary artery
associated with Scleroderma, Systemic; DNA:repeats, SNPs:promoter:(CCTTT), c.-1026C>T, c.-277A>G (human)		 RGD PMID:11104748 PMID:16113050 PMID:16456243 PMID:16813666 PMID:19912632 RGD:1580936 RGD:1580940 RGD:4891462 RGD:4891468 RGD:5132602 NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment
susceptibility		 ISO associated with chronic obstructive pulmonary disease; DNA:polymorphism:cds:p.G894T (human)
mRNA, protein:increased expression:pulmonary endothelial cell
DNA:polymorphism:cds:p.E298D (human)
RNA:increased expression:lung
CTD Direct Evidence: marker/mechanism
associated with Beta-Thalassemia;DNA:repeats:intron:
associated with heart disease; protein:increased expression:endothelial cell
protein:increased expression:arteriole		 RGD
CTD		 PMID:11686901 PMID:17065228 PMID:18953956 PMID:19487814 PMID:19912632 More... RGD:11533642 RGD:13504742 RGD:4892004 RGD:4892009 RGD:4892010 RGD:4892038 RGD:4892039 RGD:4892042 RGD:4892043 RGD:5132602 RGD:5132631 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534 		JBrowse link
G Notch1 notch receptor 1 ameliorates ISO RGD PMID:34739767 RGD:155646132 NCBI chrNW_004936669:1,292,016...1,334,061
Ensembl chrNW_004936669:1,292,088...1,332,428 		JBrowse link
G Nox1 NADPH oxidase 1 ameliorates
treatment		 ISO mRNA,protein:increased expression:lung RGD PMID:23706097 PMID:24233492 PMID:27401289 RGD:329955359 RGD:329955361 RGD:329955579 NCBI chrNW_004936584:6,023,960...6,040,041
Ensembl chrNW_004936584:6,024,008...6,039,866 		JBrowse link
G Nox4 NADPH oxidase 4 ISO associated with Anoxia;mRNA, protein:increased expression:lung RGD PMID:18952568 RGD:4762683 NCBI chrNW_004936736:230,465...394,859
Ensembl chrNW_004936736:230,476...396,708 		JBrowse link
G Nppa natriuretic peptide A ISO RGD PMID:2136863 RGD:7247720 NCBI chrNW_004936474:671,362...673,610 JBrowse link
G Nppb natriuretic peptide B severity ISO protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:16893710 PMID:16936438 PMID:20408845 PMID:21351102 RGD:1642203 RGD:1642205 NCBI chrNW_004936474:683,325...684,662
Ensembl chrNW_004936474:683,325...684,665 		JBrowse link
G Pde3a phosphodiesterase 3A ISO mRNA:increased expression:pulmonary artery RGD PMID:12466227 RGD:1582528 NCBI chrNW_004936548:5,758,634...6,072,195
Ensembl chrNW_004936548:5,762,507...6,070,576 		JBrowse link
G Pde5a phosphodiesterase 5A ISO RGD PMID:19881228 RGD:2314460 NCBI chrNW_004936869:24,265...117,120
Ensembl chrNW_004936869:39,122...117,127 		JBrowse link
G Pdgfa platelet derived growth factor subunit A ISO RGD PMID:8447423 RGD:1580847 NCBI chrNW_004936754:808,894...828,554
Ensembl chrNW_004936754:808,213...828,613 		JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO RGD PMID:8447423 PMID:21819559 PMID:22523431 RGD:1580847 RGD:6482831 RGD:6482859 NCBI chrNW_004936492:2,353,840...2,368,573
Ensembl chrNW_004936492:2,353,841...2,368,573 		JBrowse link
G Pdia3 protein disulfide isomerase family A member 3 ISO protein:increased expression:lung: RGD PMID:23315792 RGD:9999167 NCBI chrNW_004936471:6,809,181...6,834,189
Ensembl chrNW_004936471:6,809,195...6,836,169 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 treatment ISO RGD PMID:22559233 RGD:10400914 NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500 		JBrowse link
G Pgf placental growth factor ISO associated with Anemia, Sickle Cell;protein:increased expression:plasma
associated with Heart Defects, Congenital		 RGD PMID:20040765 PMID:20195855 RGD:6483588 RGD:6483610 NCBI chrNW_004936488:4,098,187...4,111,108
Ensembl chrNW_004936488:4,098,225...4,111,142 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21351102 NCBI chrNW_004936787:330,390...1,491,994
Ensembl chrNW_004936787:332,342...1,491,285 		JBrowse link
G Ptgis prostaglandin I2 synthase susceptibility
treatment		 ISO rat gene in a mouse model
protein:decreased expression:pulmonary artery (human)
human gene in a rat model		 RGD PMID:10359560 PMID:12019369 PMID:15684702 PMID:32673988 RGD:1580695 RGD:401959405 RGD:401960100 RGD:727270 NCBI chrNW_004936514:4,775,884...4,814,574
Ensembl chrNW_004936514:4,791,031...4,812,027 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO anoxia associated; RGD PMID:18542928 PMID:19577709 RGD:2300276 RGD:5135495 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO RGD PMID:16244766 RGD:1581290 NCBI chrNW_004936470:10,379,855...10,578,531
Ensembl chrNW_004936470:10,379,872...10,578,543 		JBrowse link
G Ramp2 receptor activity modifying protein 2 ISO mRNA:increased expression:heart right ventricle RGD PMID:17437045 RGD:1642678 NCBI chrNW_004936490:17,479,899...17,481,788
Ensembl chrNW_004936490:17,479,650...17,482,716 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:altered localization:nucleus, blood vessel endothelial cell, lung
associated with Hypoxia;protein:increased expression:pulmonary artery,smooth muscle tissue (mouse)		 RGD PMID:17934115 PMID:30172777 RGD:2298843 RGD:329955443 NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813 		JBrowse link
G Rhoa ras homolog family member A ISO protein:altered localization:membrane, artery, lung
protein:altered localization:pulmonary artery		 RGD PMID:16322374 PMID:18091588 RGD:1642819 RGD:2298877 NCBI chrNW_004936529:1,000,050...1,045,655
Ensembl chrNW_004936529:999,935...1,045,681 		JBrowse link
G Ryr1 ryanodine receptor 1 ISO protein:altered localization: : RGD PMID:24692174 RGD:329813077 NCBI chrNW_004936801:1,185,615...1,298,416
Ensembl chrNW_004936801:1,185,733...1,298,289 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO protein:increased expression:pulmonary artery RGD PMID:22962011 RGD:329813078 NCBI chrNW_004936484:15,402,488...15,825,410
Ensembl chrNW_004936484:15,403,819...15,824,441 		JBrowse link
G Ryr3 ryanodine receptor 3 ISO protein:altered localization: : RGD PMID:24692174 RGD:329813077 NCBI chrNW_004936673:2,078,095...2,434,872
Ensembl chrNW_004936673:1,932,755...2,434,066 		JBrowse link
G Serpine1 serpin family E member 1 treatment ISO DNA:polymorphism:3'utr
mRNA, protein:decreased expression:lung		 RGD PMID:18337154 PMID:20300292 PMID:27115515 RGD:11073610 RGD:4143527 RGD:4143529 NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123 		JBrowse link
G Slc1a5 solute carrier family 1 member 5 ISO protein:increased expression:myocytes plasma membrane, right ventricle RGD PMID:23794090 RGD:151361111 NCBI chrNW_004936664:599,012...610,689
Ensembl chrNW_004936664:598,468...610,698 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 ISO RGD PMID:19043358 RGD:2313622 NCBI chrNW_004936595:567,267...574,051
Ensembl chrNW_004936595:567,219...574,059 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24614111 NCBI chrNW_004936559:333,461...364,737
Ensembl chrNW_004936559:331,917...364,852 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 onset
no_association
severity		 ISO DNA:repeat:promoter (human)
DNA:polymorphism, repeat:promoter, intron (human)
associated with Anoxia
associated with Heart Septal Defects, Ventricular;DNA:polymorphisms (human)
CTD Direct Evidence: marker/mechanism
associated with Pulmonary Disease, Chronic Obstructive;DNA:polymorphism (human)		 RGD
CTD		 PMID:11259539 PMID:16339917 PMID:16399993 PMID:18074800 PMID:18506000 More... RGD:4889430 RGD:4889432 RGD:4889434 RGD:4889435 RGD:4889437 RGD:4889440 RGD:4889442 RGD:4889445 NCBI chrNW_004936538:6,205,268...6,239,062
Ensembl chrNW_004936538:6,205,251...6,239,083 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO protein:increased expression:pulmonary artery, smooth muscle cell RGD PMID:17192285 RGD:1642711 NCBI chrNW_004936508:10,894,918...11,256,084
Ensembl chrNW_004936508:10,968,656...11,253,070 		JBrowse link
G Smad1 SMAD family member 1 ISO protein:decreased phosphorylation:lung, vascular associated smooth muscle cell
protein:decreased expression, increased phosphorylation:lung		 RGD PMID:17347486 PMID:18367643 RGD:12903274 RGD:1643222 NCBI chrNW_004936535:3,582,512...3,626,312
Ensembl chrNW_004936535:3,582,489...3,657,063 		JBrowse link
G Smad4 SMAD family member 4 ISO RGD PMID:17347486 PMID:18367643 RGD:12903274 RGD:1643222 NCBI chrNW_004936497:12,242,869...12,278,012
Ensembl chrNW_004936497:12,249,140...12,278,123 		JBrowse link
G Smad6 SMAD family member 6 ISO mRNA:decreased expression:lung RGD PMID:17347486 RGD:1643222 NCBI chrNW_004936471:26,781,420...26,856,556
Ensembl chrNW_004936471:26,781,549...26,856,571 		JBrowse link
G Smad7 SMAD family member 7 ISO RGD PMID:17347486 RGD:1643222 NCBI chrNW_004936497:13,894,586...13,921,978
Ensembl chrNW_004936497:13,894,580...13,922,065 		JBrowse link
G Smad9 SMAD family member 9 ISO RGD PMID:17347486 RGD:1643222 NCBI chrNW_004936472:30,980,850...31,050,138
Ensembl chrNW_004936472:30,980,928...31,049,618 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 treatment ISO RGD PMID:19088082 RGD:10042965 NCBI chrNW_004936475:18,667,563...18,755,132
Ensembl chrNW_004936475:18,671,428...18,755,208 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20110409 NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781 		JBrowse link
G Sox17 SRY-box transcription factor 17 ISO protein:decreased expression:lung (rat) RGD PMID:36913491 RGD:329853317 NCBI chrNW_004936496:1,248,582...1,251,406
Ensembl chrNW_004936496:1,248,577...1,251,430 		JBrowse link
G Tac1 tachykinin precursor 1 ISO RGD PMID:12662901 RGD:5147638 NCBI chrNW_004936585:2,932,783...2,941,141
Ensembl chrNW_004936585:2,932,727...2,941,384 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:12662901 RGD:5147638 NCBI chrNW_004936556:1,266,621...1,421,271
Ensembl chrNW_004936556:1,266,613...1,421,275 		JBrowse link
G Tacr2 tachykinin receptor 2 ISO RGD PMID:12662901 RGD:5147638 NCBI chrNW_004936521:9,053,179...9,065,790
Ensembl chrNW_004936521:9,053,179...9,065,797 		JBrowse link
G Tek TEK receptor tyrosine kinase ISO mRNA, protein:increased expression:lung RGD PMID:16917117 RGD:1601487 NCBI chrNW_004936611:2,420,176...2,531,726
Ensembl chrNW_004936611:2,420,172...2,531,722 		JBrowse link
G Tert telomerase reverse transcriptase treatment ISO RGD PMID:24376652 RGD:11038675 NCBI chrNW_004936815:468,987...492,666
Ensembl chrNW_004936815:469,020...491,697 		JBrowse link
G Tgfa transforming growth factor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18424623 NCBI chrNW_004936491:14,659,089...14,758,614
Ensembl chrNW_004936491:14,657,100...14,758,848 		JBrowse link
G Tgfb1 transforming growth factor beta 1 onset ISO protein:increased expression:blood
DNA:SNPs: :multiple (human)		 RGD PMID:18496036 PMID:19324949 RGD:4145138 RGD:4145273 NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272 		JBrowse link
G Tgfbr1 transforming growth factor beta receptor 1 ISO RGD PMID:18202349 RGD:2302019 NCBI chrNW_004936524:7,656,523...7,680,043
Ensembl chrNW_004936524:7,655,847...7,681,097 		JBrowse link
G Tgfbr2 transforming growth factor beta receptor 2 ISO mRNA:decreased expression:lung RGD PMID:17392319 RGD:1601116 NCBI chrNW_004936473:21,324,669...21,409,430
Ensembl chrNW_004936473:21,324,658...21,409,430 		JBrowse link
G Thbd thrombomodulin ISO associated with Mixed Connective Tissue Disease RGD PMID:16784493 RGD:1601639 NCBI chrNW_004936620:2,563,900...2,568,117 JBrowse link
G Thpo thrombopoietin ISO protein:increased expression:pulmonary artery, plasma RGD PMID:12487786 RGD:1580087 NCBI chrNW_004936578:5,508,669...5,515,984
Ensembl chrNW_004936578:5,509,111...5,515,103 		JBrowse link
G Tlr4 toll like receptor 4 ISO associated with anoxia RGD PMID:20205596 RGD:4144108 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
G Tnc tenascin C severity ISO protein:increased expression:plasma RGD PMID:15879421 PMID:16782755 PMID:19288153 PMID:20528622 RGD:4889562 RGD:4889564 RGD:4889567 RGD:4889570 NCBI chrNW_004936487:4,172,263...4,256,780
Ensembl chrNW_004936487:4,172,886...4,233,126 		JBrowse link
G Tnf tumor necrosis factor ISO associated with Pulmonary Edema; protein:increased expression:Bronchoalveolar Lavage Fluid
CTD Direct Evidence: therapeutic
associated with pulmonary disease, chronic obstructive; protein:increased expression:serum		 RGD
CTD		 PMID:2518282 PMID:9628235 PMID:12391106 PMID:16899829 RGD:4142833 RGD:4143280 RGD:4143422 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
G Tp53 tumor protein p53 treatment ISO RGD PMID:24334871 RGD:10043360 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 ISO protein:increased expression:lung RGD PMID:24270264 RGD:9586752 NCBI chrNW_004936471:6,589,395...6,668,242
Ensembl chrNW_004936471:6,589,564...6,668,305 		JBrowse link
G Tph1 tryptophan hydroxylase 1 severity ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17675372 PMID:18506000 RGD:5686352 NCBI chrNW_004936528:1,090,529...1,116,081
Ensembl chrNW_004936528:1,096,352...1,115,688 		JBrowse link
G Tph2 tryptophan hydroxylase 2 severity ISO DNA:SNP: :1473C>G (mouse) RGD PMID:17675372 RGD:5686352 NCBI chrNW_004936568:974,575...1,065,800
Ensembl chrNW_004936568:974,767...1,065,804 		JBrowse link
G Trpc3 transient receptor potential cation channel subfamily C member 3 ISO RGD PMID:15358862 RGD:1580490 NCBI chrNW_004936662:1,130,555...1,171,352
Ensembl chrNW_004936662:1,129,278...1,171,378 		JBrowse link
G Trpc6 transient receptor potential cation channel subfamily C member 6 ISO RGD PMID:15358862 RGD:1580490 NCBI chrNW_004936551:6,173,588...6,282,971
Ensembl chrNW_004936551:6,174,122...6,282,925 		JBrowse link
G Trpv4 transient receptor potential cation channel subfamily V member 4 ISO protein:increased expression:pulmonary artery RGD PMID:22962011 RGD:329813078 NCBI chrNW_004936769:1,424,526...1,447,547
Ensembl chrNW_004936769:1,424,549...1,447,516 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 treatment ISO RGD PMID:25593290 RGD:38500244 NCBI chrNW_004936546:5,331,220...5,332,669
Ensembl chrNW_004936546:5,331,863...5,332,555 		JBrowse link
G Uts2 urotensin 2 ISO RGD PMID:15042392 RGD:2306848 NCBI chrNW_004936623:2,339,259...2,345,717
Ensembl chrNW_004936623:2,340,778...2,345,700 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:blood vessel endothelium RGD PMID:17934115 RGD:2298843 NCBI chrNW_004936748:785,491...802,791
Ensembl chrNW_004936748:785,455...803,048 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO associated with Hypoxia;protein:increased expression:pulmonary artery,smooth muscle tissue (mouse) RGD PMID:30172777 RGD:329955443 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
G Vegfb vascular endothelial growth factor B ISO RGD PMID:12547729 RGD:1625708 NCBI chrNW_004936599:4,963,161...4,966,258
Ensembl chrNW_004936599:4,962,222...4,966,264 		JBrowse link
G Vim vimentin ISO protein:increased expression, increased phosphorylation:lung RGD PMID:25593290 RGD:38500244 NCBI chrNW_004936520:10,051,692...10,059,324
Ensembl chrNW_004936520:10,052,012...10,059,182 		JBrowse link
G Vip vasoactive intestinal peptide ISO RGD PMID:22140628 RGD:5685374 NCBI chrNW_004936489:5,425,778...5,434,483
Ensembl chrNW_004936489:5,425,726...5,434,785 		JBrowse link
G Vwf von Willebrand factor ISO RGD PMID:14507115 RGD:1580645 NCBI chrNW_004936709:1,578,137...1,741,877
Ensembl chrNW_004936709:1,579,096...1,741,754 		JBrowse link
HUPRA Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sars1 seryl-tRNA synthetase 1 ISO ClinVar Annotator: match by term: HYPERURICEMIA, PULMONARY HYPERTENSION, RENAL FAILURE, AND ALKALOSIS SYNDROME ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004936704:747,109...766,981
Ensembl chrNW_004936704:746,775...771,305 		JBrowse link
G Sars2 seryl-tRNA synthetase 2, mitochondrial ISO ClinVar Annotator: match by term: HYPERURICEMIA, PULMONARY HYPERTENSION, RENAL FAILURE, AND ALKALOSIS SYNDROME | ClinVar Annotator: match by term: Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:21255763 PMID:24034276 PMID:25741868 More... NCBI chrNW_004936661:1,861,646...1,871,707
Ensembl chrNW_004936661:1,861,646...1,871,687 		JBrowse link
Neonatal Pulmonary Hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cps1 carbamoyl-phosphate synthase 1 ISO ClinVar Annotator: match by term: Pulmonary hypertension, neonatal, susceptibility to ClinVar
OMIM		 PMID:8486760 PMID:9536098 PMID:9686343 PMID:9711878 PMID:11388595 More... NCBI chrNW_004936586:5,739,038...5,850,317
Ensembl chrNW_004936586:5,739,337...5,850,312 		JBrowse link
persistent fetal circulation syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adad2 adenosine deaminase domain containing 2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,641,123...3,645,624
Ensembl chrNW_004936641:3,641,215...3,645,742 		JBrowse link
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,498,693...3,547,968
Ensembl chrNW_004936641:3,498,693...3,547,968 		JBrowse link
G Cibar2 CBY1 interacting BAR domain containing 2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,099,616...3,109,969 JBrowse link
G Cotl1 coactosin like F-actin binding protein 1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,422,734...3,458,830
Ensembl chrNW_004936641:3,423,144...3,455,432 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO CTD Direct Evidence: marker/mechanism
CACD, OMIM:265380, DNA:polymorphism:T1405N 		CTD
RGD		 PMID:11407344 RGD:1600716 NCBI chrNW_004936586:5,739,038...5,850,317
Ensembl chrNW_004936586:5,739,337...5,850,312 		JBrowse link
G Crispld2 cysteine rich secretory protein LCCL domain containing 2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,228,791...3,277,379
Ensembl chrNW_004936641:3,228,762...3,277,427 		JBrowse link
G CUNH16orf74 chromosome unknown C16orf74 homolog ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:2,730,252...2,752,176 JBrowse link
G CUNH16orf95 chromosome unknown C16orf95 homolog ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:1,843,874...1,850,488 JBrowse link
G Dnaaf1 dynein axonemal assembly factor 1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,656,331...3,674,907
Ensembl chrNW_004936641:3,657,058...3,673,729 		JBrowse link
G Emc8 ER membrane protein complex subunit 8 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:2,696,184...2,710,141
Ensembl chrNW_004936641:2,696,178...2,710,180 		JBrowse link
G Fbxo31 F-box protein 31 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:1,801,539...1,831,988
Ensembl chrNW_004936641:1,801,548...1,830,440 		JBrowse link
G Foxc2 forkhead box C2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:2,236,224...2,238,501
Ensembl chrNW_004936641:2,236,873...2,238,375 		JBrowse link
G Foxf1 forkhead box F1 ISO ClinVar Annotator: match by term: ALVEOLAR CAPILLARY DYSPLASIA WITH MISALIGNMENT OF PULMONARY VEINS AND OTHER CONGENITAL ANOMALIES | ClinVar Annotator: match by term: Alveolar capillary dysplasia with misalignment of pulmonary veins | ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia OMIM
ClinVar		 PMID:15520767 PMID:19500772 PMID:23505205 PMID:24033266 PMID:25741868 More... NCBI chrNW_004943883:4...1,756 JBrowse link
G Foxl1 forkhead box L1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:2,226,489...2,227,613
Ensembl chrNW_004936641:2,226,550...2,227,578 		JBrowse link
G Gins2 GINS complex subunit 2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:2,757,150...2,775,904
Ensembl chrNW_004936641:2,757,150...2,776,681 		JBrowse link
G Gse1 Gse1 coiled-coil protein ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:2,779,521...2,920,840
Ensembl chrNW_004936641:2,776,714...2,862,484 		JBrowse link
G Hsdl1 hydroxysteroid dehydrogenase like 1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,674,575...3,692,175
Ensembl chrNW_004936641:3,681,960...3,693,063 		JBrowse link
G Irf8 interferon regulatory factor 8 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:2,608,109...2,622,446
Ensembl chrNW_004936641:2,608,100...2,622,409 		JBrowse link
G Itgam integrin subunit alpha M ISO DNA:missense mutation:CDS:p.E1071D (human) RGD PMID:32054482 RGD:329853760 NCBI chrNW_004936543:8,460,526...8,508,524
Ensembl chrNW_004936543:8,461,307...8,508,524 		JBrowse link
G Jph3 junctophilin 3 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:1,619,640...1,668,480
Ensembl chrNW_004936641:1,620,652...1,668,486 		JBrowse link
G Kcng4 potassium voltage-gated channel modifier subfamily G member 4 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,618,756...3,633,505
Ensembl chrNW_004936641:3,618,906...3,630,033 		JBrowse link
G Kiaa0513 KIAA0513 ortholog ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,113,634...3,167,019
Ensembl chrNW_004936641:3,113,634...3,132,062 		JBrowse link
G Klhl36 kelch like family member 36 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,392,253...3,403,575
Ensembl chrNW_004936641:3,388,887...3,403,581 		JBrowse link
G LOC101971634 cytochrome c oxidase subunit 4 isoform 1, mitochondrial ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:2,690,723...2,695,230
Ensembl chrNW_004936641:2,690,176...2,695,387 		JBrowse link
G Mbtps1 membrane bound transcription factor peptidase, site 1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,696,506...3,751,558
Ensembl chrNW_004936641:3,696,536...3,751,598 		JBrowse link
G Meak7 MTOR associated protein, eak-7 homolog ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,490,531...3,498,615 JBrowse link
G Mlycd malonyl-CoA decarboxylase ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,836,418...3,846,485 JBrowse link
G Mthfsd methenyltetrahydrofolate synthetase domain containing ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:2,245,752...2,259,989
Ensembl chrNW_004936641:2,247,221...2,262,259 		JBrowse link
G Necab2 N-terminal EF-hand calcium binding protein 2 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,779,024...3,802,883
Ensembl chrNW_004936641:3,779,374...3,799,581 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO OMIM:265380 MouseDO NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,803,799...3,812,995
Ensembl chrNW_004936641:3,803,767...3,813,041 		JBrowse link
G Pten phosphatase and tensin homolog ISO OMIM:265380 MouseDO NCBI chrNW_004936735:1,252,414...1,338,318
Ensembl chrNW_004936735:1,252,414...1,338,323 		JBrowse link
G Slc38a8 solute carrier family 38 member 8 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,757,107...3,778,939
Ensembl chrNW_004936641:3,757,130...3,774,098 		JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17273977 NCBI chrNW_004936471:33,224,174...33,245,076
Ensembl chrNW_004936471:33,224,859...33,245,030 		JBrowse link
G Taf1c TATA-box binding protein associated factor, RNA polymerase I subunit C ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,649,177...3,653,798 JBrowse link
G Usp10 ubiquitin specific peptidase 10 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,308,121...3,350,476
Ensembl chrNW_004936641:3,307,931...3,350,517 		JBrowse link
G Zcchc14 zinc finger CCHC-type containing 14 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:1,728,596...1,783,710
Ensembl chrNW_004936641:1,728,592...1,781,896 		JBrowse link
G Zdhhc7 zinc finger DHHC-type palmitoyltransferase 7 ISO ClinVar Annotator: match by term: Congenital alveolar capillary dysplasia ClinVar NCBI chrNW_004936641:3,175,338...3,199,487
Ensembl chrNW_004936641:3,175,338...3,199,484 		JBrowse link
primary pulmonary hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl interactor 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:30,109...101,748
Ensembl chrNW_004936631:30,199...98,511 		JBrowse link
G Acadl acyl-CoA dehydrogenase long chain ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936845:66,674...96,248
Ensembl chrNW_004936845:66,241...96,249 		JBrowse link
G Acvrl1 activin A receptor like type 1 ISO ClinVar Annotator: match by term: Heritable pulmonary arterial hypertension ClinVar PMID:25741868 PMID:28492532 PMID:31727138 NCBI chrNW_004936512:9,364,551...9,379,131
Ensembl chrNW_004936512:9,364,149...9,379,431 		JBrowse link
G Adam23 ADAM metallopeptidase domain 23 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:2,777,595...2,946,191
Ensembl chrNW_004936631:2,778,849...2,946,187 		JBrowse link
G Adora2a adenosine A2a receptor ISO OMIM:178600 | OMIM:265400 | OMIM:615342 | OMIM:615343 | OMIM:615344 MouseDO NCBI chrNW_004936619:597,970...618,564
Ensembl chrNW_004936619:608,441...616,779 		JBrowse link
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:16429395 PMID:16429403 PMID:27453251 PMID:28492532 PMID:29743074 NCBI chrNW_004936726:940,696...1,015,771
Ensembl chrNW_004936726:939,341...1,015,799 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B ISO ClinVar Annotator: match by term: Idiopathic pulmonary arterial hypertension ClinVar PMID:22374147 PMID:25741868 PMID:25758993 PMID:28492532 NCBI chrNW_004936687:2,346,601...2,595,283
Ensembl chrNW_004936687:2,503,777...2,597,522 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 ISO ClinVar Annotator: match by term: Idiopathic and/or familial pulmonary arterial hypertension | ClinVar Annotator: match by term: Primary pulmonary hypertension | ClinVar Annotator: match by term: Pulmonary hypertension, primary, dexfenfluramine-associated | ClinVar Annotator: match by term: Pulmonary hypertension, primary, fenfluramine-associated ClinVar PMID:3291115 PMID:9536098 PMID:10903931 PMID:10973254 PMID:11015450 More... NCBI chrNW_004936726:1,543,263...1,711,422
Ensembl chrNW_004936726:1,543,245...1,704,541 		JBrowse link
G Carf calcium responsive transcription factor ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936726:1,958,561...2,010,972
Ensembl chrNW_004936726:1,922,060...2,010,981 		JBrowse link
G Cav1 caveolin 1 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chrNW_004936589:2,504,235...2,536,778
Ensembl chrNW_004936589:2,504,224...2,537,170 		JBrowse link
G Ccnyl1 cyclin Y like 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:3,867,403...3,905,423
Ensembl chrNW_004936631:3,867,407...3,904,997 		JBrowse link
G Cd28 CD28 molecule ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:335,411...363,407
Ensembl chrNW_004936631:335,411...363,407 		JBrowse link
G Cdk15 cyclin dependent kinase 15 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:16429395 PMID:16429403 PMID:27453251 PMID:28492532 PMID:29743074 NCBI chrNW_004936726:1,037,614...1,129,961
Ensembl chrNW_004936726:1,037,636...1,130,571 		JBrowse link
G Cmklr2 chemerin chemokine-like receptor 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:2,544,951...2,580,306
Ensembl chrNW_004936631:2,545,241...2,546,308 		JBrowse link
G Cpo carboxypeptidase O ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:3,219,512...3,243,462
Ensembl chrNW_004936631:3,219,512...3,243,462 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936586:5,739,038...5,850,317
Ensembl chrNW_004936586:5,739,337...5,850,312 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:3,721,307...3,785,346
Ensembl chrNW_004936631:3,721,313...3,780,892 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:484,356...489,643
Ensembl chrNW_004936631:484,356...489,643 		JBrowse link
G CUNH2orf80 chromosome unknown C2orf80 homolog ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936950:405,464...438,524
Ensembl chrNW_004936950:435,444...438,575
Ensembl chrNW_004936950:435,444...438,575 		JBrowse link
G Dytn dystrotelin ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:2,975,543...3,041,219
Ensembl chrNW_004936631:2,975,509...3,030,779 		JBrowse link
G Eef1b2 eukaryotic translation elongation factor 1 beta 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:2,539,075...2,542,252
Ensembl chrNW_004936631:2,539,070...2,542,419 		JBrowse link
G Fam117b family with sequence similarity 117 member B ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936726:1,753,318...1,846,977
Ensembl chrNW_004936726:1,753,652...1,843,405 		JBrowse link
G Fastkd2 FAST kinase domains 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:3,074,719...3,099,233
Ensembl chrNW_004936631:3,074,664...3,102,079 		JBrowse link
G Fbxo32 F-box protein 32 ISO mRNA:increased expression:vastus lateralis RGD PMID:23972212 RGD:329812002 NCBI chrNW_004936470:23,886,836...23,919,063
Ensembl chrNW_004936470:23,886,970...23,918,258 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 ISO protein:increased expression:lung (human) RGD PMID:29722558 RGD:155791445 NCBI chrNW_004936486:10,506,680...10,606,272
Ensembl chrNW_004936486:10,507,097...10,602,019 		JBrowse link
G Foxf1 forkhead box F1 ISO ClinVar Annotator: match by term: Idiopathic and/or familial pulmonary arterial hypertension ClinVar PMID:19500772 PMID:19592680 PMID:19812545 PMID:20425831 PMID:22766610 More... NCBI chrNW_004943883:4...1,756 JBrowse link
G Fzd5 frizzled class receptor 5 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:3,909,046...3,915,939
Ensembl chrNW_004936631:3,911,693...3,915,560 		JBrowse link
G Fzd7 frizzled class receptor 7 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:16429395 PMID:16429403 PMID:27453251 PMID:28492532 PMID:29743074 NCBI chrNW_004936726:1,256,684...1,275,324
Ensembl chrNW_004936726:1,256,678...1,275,467 		JBrowse link
G Hdac1 histone deacetylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22711276 NCBI chrNW_004936474:15,320,635...15,351,418
Ensembl chrNW_004936474:15,320,729...15,350,860 		JBrowse link
G Hdac4 histone deacetylase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22711276 NCBI chrNW_004936745:1,730,743...1,942,071
Ensembl chrNW_004936745:1,730,694...1,942,074 		JBrowse link
G Hdac5 histone deacetylase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22711276 NCBI chrNW_004936541:561,721...598,915
Ensembl chrNW_004936541:558,414...599,195 		JBrowse link
G Ica1l islet cell autoantigen 1 like ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936726:1,853,178...1,922,684
Ensembl chrNW_004936726:1,853,868...1,902,788 		JBrowse link
G Icos inducible T cell costimulator ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:562,650...572,263
Ensembl chrNW_004936631:551,394...570,804 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein ISO protein:decreased expression:lung, wall of arteriole (human) RGD PMID:20522807 RGD:9686087 NCBI chrNW_004936485:18,610,721...18,611,889
Ensembl chrNW_004936485:18,610,665...18,612,059 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936950:334,894...349,221
Ensembl chrNW_004936950:334,934...348,363 		JBrowse link
G Ino80d INO80 complex subunit D ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:2,405,056...2,474,798
Ensembl chrNW_004936631:2,410,300...2,474,811 		JBrowse link
G Kansl1l KAT8 regulatory NSL complex subunit 1 like ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936845:123,713...248,857
Ensembl chrNW_004936845:109,432...246,833 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chrNW_004936493:5,767,779...5,772,043
Ensembl chrNW_004936493:5,770,103...5,772,326 		JBrowse link
G Klf7 KLF transcription factor 7 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:3,327,555...3,412,206
Ensembl chrNW_004936631:3,329,681...3,412,252 		JBrowse link
G Lancl1 LanC like glutathione S-transferase 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936586:5,917,470...5,950,101
Ensembl chrNW_004936586:5,917,413...5,952,952 		JBrowse link
G LOC101964504 cytochrome P450 20A1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936726:2,234,611...2,295,527
Ensembl chrNW_004936726:2,235,361...2,298,775 		JBrowse link
G Map2 microtubule associated protein 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936845:475,406...752,600
Ensembl chrNW_004936845:473,366...545,135 		JBrowse link
G Mdh1b malate dehydrogenase 1B ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:3,050,689...3,074,396
Ensembl chrNW_004936631:3,057,345...3,074,350 		JBrowse link
G Mettl21a methyltransferase 21A, HSPA lysine ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:3,789,577...3,804,747
Ensembl chrNW_004936631:3,788,754...3,804,844 		JBrowse link
G Mfn1 mitofusin 1 ISO protein:decreased expression:vastus lateralis RGD PMID:23972212 RGD:329812002 NCBI chrNW_004936566:3,737,315...3,775,894
Ensembl chrNW_004936566:3,737,315...3,775,693 		JBrowse link
G Mfn2 mitofusin 2 ISO protein:decreased expression:vastus lateralis RGD PMID:23972212 RGD:329812002 NCBI chrNW_004936474:767,754...795,258
Ensembl chrNW_004936474:767,671...796,556 		JBrowse link
G Myl1 myosin light chain 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936586:5,993,177...6,013,426
Ensembl chrNW_004936586:5,993,098...6,013,994 		JBrowse link
G Nbeal1 neurobeachin like 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936726:2,045,202...2,224,477
Ensembl chrNW_004936726:2,045,191...2,224,251 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:2,503,353...2,538,957
Ensembl chrNW_004936631:2,499,062...2,538,801 		JBrowse link
G Nop58 NOP58 ribonucleoprotein ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:16429395 PMID:16429403 PMID:27453251 PMID:28492532 PMID:29743074 NCBI chrNW_004936726:1,457,038...1,487,374
Ensembl chrNW_004936726:1,457,002...1,486,530 		JBrowse link
G Nrp2 neuropilin 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:2,106,378...2,222,082
Ensembl chrNW_004936631:2,106,453...2,222,088 		JBrowse link
G Pard3b par-3 family cell polarity regulator beta ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:1,079,002...2,058,494
Ensembl chrNW_004936631:1,079,478...2,054,258 		JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936950:242,071...323,204
Ensembl chrNW_004936950:242,522...320,078 		JBrowse link
G Plekhm3 pleckstrin homology domain containing M3 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:3,954,774...4,138,079
Ensembl chrNW_004936631:3,960,725...4,138,096 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO OMIM:178600 | OMIM:265400 | OMIM:615342 | OMIM:615343 | OMIM:615344 MouseDO NCBI chrNW_004936602:1,230,907...1,368,588
Ensembl chrNW_004936602:1,230,907...1,304,743 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO DNA:SNP, missense mutations:intron 4, CDS:c.521+1G>A, p.R252Q (c.755G>A), p.A447T (c.1339G>A) (, rs759344518, rs146531327) (human) RGD PMID:32236489 RGD:401901150 NCBI chrNW_004936514:4,775,884...4,814,574
Ensembl chrNW_004936514:4,791,031...4,812,027 		JBrowse link
G Pth2r parathyroid hormone 2 receptor ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936950:114,265...181,948
Ensembl chrNW_004936950:114,317...204,718 		JBrowse link
G Raph1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:100,072...196,557
Ensembl chrNW_004936631:108,310...196,563 		JBrowse link
G Rfc1 replication factor C subunit 1 ISO mRNA:increased expression:lung (human) RGD PMID:37410515 RGD:401940160 NCBI chrNW_004936482:6,938,138...7,009,144
Ensembl chrNW_004936482:6,938,681...6,993,705 		JBrowse link
G Rpe ribulose-5-phosphate-3-epimerase ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936845:188,414...264,070 JBrowse link
G Ryr1 ryanodine receptor 1 ISO protein:increased phosphorylation:vastus lateralis RGD PMID:23972212 RGD:329812002 NCBI chrNW_004936801:1,185,615...1,298,416
Ensembl chrNW_004936801:1,185,733...1,298,289 		JBrowse link
G Smad9 SMAD family member 9 ISO OMIM:178600 | OMIM:265400 | OMIM:615342 | OMIM:615343 | OMIM:615344
CTD Direct Evidence: marker/mechanism		 MouseDO
CTD		 NCBI chrNW_004936472:30,980,850...31,050,138
Ensembl chrNW_004936472:30,980,928...31,049,618 		JBrowse link
G Sox17 SRY-box transcription factor 17 ISO protein:decreased expression:pulmonary artery (human) RGD PMID:36919784 RGD:329853737 NCBI chrNW_004936496:1,248,582...1,251,406
Ensembl chrNW_004936496:1,248,577...1,251,430 		JBrowse link
G Sumo1 small ubiquitin like modifier 1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:16429395 PMID:16429403 PMID:27453251 PMID:28492532 PMID:29743074 NCBI chrNW_004936726:1,402,977...1,413,974
Ensembl chrNW_004936726:1,399,050...1,429,205 		JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO OMIM:178600 | OMIM:265400 | OMIM:615342 | OMIM:615343 | OMIM:615344 MouseDO NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
G Trim63 tripartite motif containing 63 ISO mRNA, protein:increased expression:vastus lateralis RGD PMID:23972212 RGD:329812002 NCBI chrNW_004936474:10,598,571...10,610,197
Ensembl chrNW_004936474:10,598,561...10,633,001 		JBrowse link
G Unc80 unc-80 homolog, NALCN channel complex subunit ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936845:268,357...454,557
Ensembl chrNW_004936845:268,919...454,031 		JBrowse link
G Vip vasoactive intestinal peptide ISO OMIM:178600 | OMIM:265400 | OMIM:615342 | OMIM:615343 | OMIM:615344 MouseDO NCBI chrNW_004936489:5,425,778...5,434,483
Ensembl chrNW_004936489:5,425,726...5,434,785 		JBrowse link
G Wdr12 WD repeat domain 12 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936726:1,931,221...1,958,457
Ensembl chrNW_004936726:1,931,183...1,958,215 		JBrowse link
G Zdbf2 zinc finger DBF-type containing 2 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:28492532 PMID:31727138 NCBI chrNW_004936631:2,649,792...2,686,430
Ensembl chrNW_004936631:2,648,381...2,686,434 		JBrowse link
Primary Pulmonary Hypertension, 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca3 ATP binding cassette subfamily A member 3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:15976379 PMID:17597647 PMID:18246475 PMID:18317237 PMID:18603241 More... NCBI chrNW_004936694:1,735,206...1,778,100
Ensembl chrNW_004936694:1,736,207...1,778,116 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25117148 PMID:25741868 NCBI chrNW_004936528:1,608,782...1,682,873
Ensembl chrNW_004936528:1,608,757...1,682,975 		JBrowse link
G Abi2 abl interactor 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936631:30,109...101,748
Ensembl chrNW_004936631:30,199...98,511 		JBrowse link
G Acvrl1 activin A receptor like type 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:9245985 PMID:11484689 PMID:12700602 PMID:14684682 PMID:15024723 More... NCBI chrNW_004936512:9,364,551...9,379,131
Ensembl chrNW_004936512:9,364,149...9,379,431 		JBrowse link
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:940,696...1,015,771
Ensembl chrNW_004936726:939,341...1,015,799 		JBrowse link
G Aox1 aldehyde oxidase 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936825:263,725...332,424
Ensembl chrNW_004936825:263,081...332,622 		JBrowse link
G Atp13a3 ATPase 13A3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 PMID:28492532 PMID:30679663 PMID:31727138 PMID:34493544 More... NCBI chrNW_004936711:325,978...400,374
Ensembl chrNW_004936711:354,020...397,145 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:24121792 PMID:25741868 PMID:26467025 PMID:28492532 PMID:31727138 NCBI chrNW_004936804:52,435...115,289
Ensembl chrNW_004936804:48,947...115,412 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 | ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia OMIM
ClinVar		 PMID:3291115 PMID:9536098 PMID:10903931 PMID:10973254 PMID:11015450 More... NCBI chrNW_004936726:1,543,263...1,711,422
Ensembl chrNW_004936726:1,543,245...1,704,541 		JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:149,391...166,075 JBrowse link
G C2cd6 C2 calcium dependent domain containing 6 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:734,269...867,709 JBrowse link
G Carf calcium responsive transcription factor ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,958,561...2,010,972
Ensembl chrNW_004936726:1,922,060...2,010,981 		JBrowse link
G Casp10 caspase 10 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:460,556...489,550
Ensembl chrNW_004936726:460,518...485,624 		JBrowse link
G Casp8 caspase 8 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:554,627...596,334
Ensembl chrNW_004936726:554,758...595,922 		JBrowse link
G Cd28 CD28 molecule ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936631:335,411...363,407
Ensembl chrNW_004936631:335,411...363,407 		JBrowse link
G Cdk15 cyclin dependent kinase 15 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,037,614...1,129,961
Ensembl chrNW_004936726:1,037,636...1,130,571 		JBrowse link
G Cflar CASP8 and FADD like apoptosis regulator ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:381,888...425,565
Ensembl chrNW_004936726:381,835...423,311 		JBrowse link
G Clk1 CDC like kinase 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:170,763...178,897
Ensembl chrNW_004936726:170,458...179,545 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936631:484,356...489,643
Ensembl chrNW_004936631:484,356...489,643 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 PMID:28492532 PMID:32581362 NCBI chrNW_004936471:3,423,792...3,527,089
Ensembl chrNW_004936471:3,423,813...3,526,913 		JBrowse link
G Eng endoglin ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:10625079 PMID:15517393 PMID:15521985 PMID:15879500 PMID:16690726 More... NCBI chrNW_004936487:15,467,165...15,499,180
Ensembl chrNW_004936487:15,467,835...15,477,488 		JBrowse link
G Fam117b family with sequence similarity 117 member B ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,753,318...1,846,977
Ensembl chrNW_004936726:1,753,652...1,843,405 		JBrowse link
G Flacc1 flagellum associated containing coiled-coil domains 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:600,213...631,513
Ensembl chrNW_004936726:600,420...625,853 		JBrowse link
G Fzd7 frizzled class receptor 7 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,256,684...1,275,324
Ensembl chrNW_004936726:1,256,678...1,275,467 		JBrowse link
G Gdf2 growth differentiation factor 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 PMID:26801773 PMID:28492532 PMID:31661308 PMID:31727138 NCBI chrNW_004936554:7,307,461...7,322,048
Ensembl chrNW_004936554:7,316,435...7,322,060 		JBrowse link
G Gjb2 gap junction protein beta 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:17666888 PMID:25741868 PMID:30755392 NCBI chrNW_004936720:1,528,205...1,530,296
Ensembl chrNW_004936720:1,528,249...1,528,929 		JBrowse link
G Hycc2 hyccin PI4KA lipid kinase complex subunit 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:261,530...338,105
Ensembl chrNW_004936726:268,873...338,048 		JBrowse link
G Hydin HYDIN axonemal central pair apparatus protein ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 NCBI chrNW_004936475:22,523,962...22,836,355 JBrowse link
G Ica1l islet cell autoantigen 1 like ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,853,178...1,922,684
Ensembl chrNW_004936726:1,853,868...1,902,788 		JBrowse link
G Icos inducible T cell costimulator ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936631:562,650...572,263
Ensembl chrNW_004936631:551,394...570,804 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:23883380 PMID:32581362 NCBI chrNW_004936493:5,767,779...5,772,043
Ensembl chrNW_004936493:5,770,103...5,772,326 		JBrowse link
G Kctd18 potassium channel tetramerization domain containing 18 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936825:396,359...415,478
Ensembl chrNW_004936825:398,875...413,993 		JBrowse link
G LOC101964504 cytochrome P450 20A1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:2,234,611...2,295,527
Ensembl chrNW_004936726:2,235,361...2,298,775 		JBrowse link
G Mpp4 MAGUK p55 scaffold protein 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:893,411...938,876
Ensembl chrNW_004936726:892,550...938,969 		JBrowse link
G Nbeal1 neurobeachin like 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:2,045,202...2,224,477
Ensembl chrNW_004936726:2,045,191...2,224,251 		JBrowse link
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:338,384...349,943
Ensembl chrNW_004936726:338,423...349,943 		JBrowse link
G Nif3l1 NGG1 interacting factor 3 like 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:194,873...212,487
Ensembl chrNW_004936726:195,010...232,429 		JBrowse link
G Nop58 NOP58 ribonucleoprotein ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:23579436 PMID:32581362 NCBI chrNW_004936726:1,457,038...1,487,374
Ensembl chrNW_004936726:1,457,002...1,486,530 		JBrowse link
G Notch1 notch receptor 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:15472075 PMID:16614245 PMID:18593716 PMID:19245433 PMID:19635999 More... NCBI chrNW_004936669:1,292,016...1,334,061
Ensembl chrNW_004936669:1,292,088...1,332,428 		JBrowse link
G Notch3 notch receptor 3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:22006983 PMID:22153900 PMID:22159056 PMID:24086431 PMID:25741868 More... NCBI chrNW_004936596:5,265,984...5,301,430
Ensembl chrNW_004936596:5,265,999...5,300,429 		JBrowse link
G Orc2 origin recognition complex subunit 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:215,483...259,867
Ensembl chrNW_004936726:211,859...255,754 		JBrowse link
G Pah phenylalanine hydroxylase ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:1301187 PMID:1682234 PMID:1769645 PMID:2044609 PMID:2574153 More... NCBI chrNW_004936492:11,342,566...11,412,323
Ensembl chrNW_004936492:11,342,518...11,412,209 		JBrowse link
G Phf6 PHD finger protein 6 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 NCBI chrNW_004936691:716,723...767,960
Ensembl chrNW_004936691:716,697...768,016 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:6144131 PMID:16144131 PMID:16283678 PMID:18602922 PMID:19283792 More... NCBI chrNW_004936750:439,396...468,747 JBrowse link
G Ppil3 peptidylprolyl isomerase like 3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:181,128...194,823
Ensembl chrNW_004936726:181,140...194,821 		JBrowse link
G Raph1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936631:100,072...196,557
Ensembl chrNW_004936631:108,310...196,563 		JBrowse link
G Sgo2 shugoshin 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936825:350,390...373,005
Ensembl chrNW_004936825:341,283...373,012 		JBrowse link
G Smad1 SMAD family member 1 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:21898662 NCBI chrNW_004936535:3,582,512...3,626,312
Ensembl chrNW_004936535:3,582,489...3,657,063 		JBrowse link
G Smad4 SMAD family member 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:21898662 PMID:24728327 PMID:25502805 PMID:25559809 PMID:25741868 More... NCBI chrNW_004936497:12,242,869...12,278,012
Ensembl chrNW_004936497:12,249,140...12,278,123 		JBrowse link
G Smad9 SMAD family member 9 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar NCBI chrNW_004936472:30,980,850...31,050,138
Ensembl chrNW_004936472:30,980,928...31,049,618 		JBrowse link
G Sox17 SRY-box transcription factor 17 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar NCBI chrNW_004936496:1,248,582...1,251,406
Ensembl chrNW_004936496:1,248,577...1,251,430 		JBrowse link
G Spats2l spermatogenesis associated serine rich 2 like ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936825:423,986...591,062
Ensembl chrNW_004936825:423,984...591,495 		JBrowse link
G Stradb STE20 related adaptor beta ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:709,037...728,696
Ensembl chrNW_004936726:709,038...731,338 		JBrowse link
G Sumo1 small ubiquitin like modifier 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,402,977...1,413,974
Ensembl chrNW_004936726:1,399,050...1,429,205 		JBrowse link
G Tbx4 T-box transcription factor 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary hypertension, primary, 1 ClinVar PMID:9536098 PMID:15106123 PMID:16199547 PMID:17576681 PMID:23592887 More... NCBI chrNW_004936490:2,823,531...2,853,282
Ensembl chrNW_004936490:2,827,416...2,852,917 		JBrowse link
G Tmem237 transmembrane protein 237 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:872,368...892,185
Ensembl chrNW_004936726:869,238...891,283 		JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 NCBI chrNW_004936529:6,788,713...6,841,824
Ensembl chrNW_004936529:6,788,187...6,841,888 		JBrowse link
G Trak2 trafficking kinesin protein 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:649,413...708,816
Ensembl chrNW_004936726:649,418...708,820 		JBrowse link
G Wdr12 WD repeat domain 12 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,931,221...1,958,457
Ensembl chrNW_004936726:1,931,183...1,958,215 		JBrowse link
Primary Pulmonary Hypertension, 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad9 SMAD family member 9 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 2 OMIM
ClinVar		 PMID:9536098 PMID:16199547 PMID:17576681 PMID:19211612 PMID:19419974 More... NCBI chrNW_004936472:30,980,850...31,050,138
Ensembl chrNW_004936472:30,980,928...31,049,618 		JBrowse link
Primary Pulmonary Hypertension, 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1b bone morphogenetic protein receptor type 1B ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 3 ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004936687:2,346,601...2,595,283
Ensembl chrNW_004936687:2,503,777...2,597,522 		JBrowse link
G Cav1 caveolin 1 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 3 OMIM
ClinVar		 PMID:22474227 PMID:25741868 PMID:28492532 PMID:29231014 PMID:31727138 NCBI chrNW_004936589:2,504,235...2,536,778
Ensembl chrNW_004936589:2,504,224...2,537,170 		JBrowse link
Primary Pulmonary Hypertension, 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnk3 potassium two pore domain channel subfamily K member 3 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, 4 OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:23883380 PMID:24033266 PMID:25741868 More... NCBI chrNW_004936493:5,767,779...5,772,043
Ensembl chrNW_004936493:5,770,103...5,772,326 		JBrowse link
Primary Pulmonary Hypertension, 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a3 ATPase 13A3 ISO ClinVar Annotator: match by term: Pulmonary hypertension, primary, autosomal recessive OMIM
ClinVar		 PMID:25741868 PMID:28492532 PMID:30679663 PMID:31727138 PMID:34493544 More... NCBI chrNW_004936711:325,978...400,374
Ensembl chrNW_004936711:354,020...397,145 		JBrowse link
Pulmonary Arterial Hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca3 ATP binding cassette subfamily A member 3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:15976379 PMID:17597647 PMID:18246475 PMID:18317237 PMID:18603241 More... NCBI chrNW_004936694:1,735,206...1,778,100
Ensembl chrNW_004936694:1,736,207...1,778,116 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25117148 PMID:25741868 NCBI chrNW_004936528:1,608,782...1,682,873
Ensembl chrNW_004936528:1,608,757...1,682,975 		JBrowse link
G Abi2 abl interactor 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936631:30,109...101,748
Ensembl chrNW_004936631:30,199...98,511 		JBrowse link
G Acvrl1 activin A receptor like type 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:11484689 PMID:15024723 PMID:15517393 PMID:15687131 PMID:16429404 More... NCBI chrNW_004936512:9,364,551...9,379,131
Ensembl chrNW_004936512:9,364,149...9,379,431 		JBrowse link
G Ahr aryl hydrocarbon receptor severity ISO CTD Direct Evidence: marker/mechanism
protein:increased activity:serum (human)		 CTD
RGD		 PMID:33836606 RGD:401940192 NCBI chrNW_004936546:3,737,908...3,783,492
Ensembl chrNW_004936546:3,737,851...3,783,588 		JBrowse link
G Ahsp alpha hemoglobin stabilizing protein ISO mRNA:altered expression: (human) RGD PMID:35710932 RGD:329961295 NCBI chrNW_004936543:8,317,344...8,325,273 JBrowse link
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:940,696...1,015,771
Ensembl chrNW_004936726:939,341...1,015,799 		JBrowse link
G Aox1 aldehyde oxidase 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936825:263,725...332,424
Ensembl chrNW_004936825:263,081...332,622 		JBrowse link
G Apln apelin treatment ISO RGD PMID:23867624 RGD:329848996 NCBI chrNW_004936479:1,889,930...1,899,811
Ensembl chrNW_004936479:1,890,229...1,899,730 		JBrowse link
G Atp13a3 ATPase 13A3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 PMID:28492532 PMID:30679663 PMID:31727138 PMID:34493544 More... NCBI chrNW_004936711:325,978...400,374
Ensembl chrNW_004936711:354,020...397,145 		JBrowse link
G Axin2 axin 2 exacerbates ISO RGD PMID:28694128 RGD:151356920 NCBI chrNW_004936541:7,155,963...7,242,466
Ensembl chrNW_004936541:7,211,985...7,242,470 		JBrowse link
G Bmp7 bone morphogenetic protein 7 ISO protein:increased expression:lung, pulmonary artery (rat) RGD PMID:31542483 RGD:155888480 NCBI chrNW_004936530:71,965...143,940
Ensembl chrNW_004936530:71,920...143,940 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease ClinVar PMID:24121792 PMID:25741868 PMID:26467025 PMID:28492532 PMID:30029678 More... NCBI chrNW_004936804:52,435...115,289
Ensembl chrNW_004936804:48,947...115,412 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease ClinVar PMID:25741868 PMID:30029678 NCBI chrNW_004936687:2,346,601...2,595,283
Ensembl chrNW_004936687:2,503,777...2,597,522 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 treatment ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease RGD
ClinVar		 PMID:3291115 PMID:10903931 PMID:10973254 PMID:11015450 PMID:11115378 More... RGD:329848996 NCBI chrNW_004936726:1,543,263...1,711,422
Ensembl chrNW_004936726:1,543,245...1,704,541 		JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:149,391...166,075 JBrowse link
G C2cd6 C2 calcium dependent domain containing 6 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:734,269...867,709 JBrowse link
G Carf calcium responsive transcription factor ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,958,561...2,010,972
Ensembl chrNW_004936726:1,922,060...2,010,981 		JBrowse link
G Casp10 caspase 10 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:460,556...489,550
Ensembl chrNW_004936726:460,518...485,624 		JBrowse link
G Casp8 caspase 8 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:554,627...596,334
Ensembl chrNW_004936726:554,758...595,922 		JBrowse link
G Cav1 caveolin 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease ClinVar PMID:25741868 PMID:30029678 NCBI chrNW_004936589:2,504,235...2,536,778
Ensembl chrNW_004936589:2,504,224...2,537,170 		JBrowse link
G Cd28 CD28 molecule ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936631:335,411...363,407
Ensembl chrNW_004936631:335,411...363,407 		JBrowse link
G Cdh2 cadherin 2 ISO mRNA:increased expression:lung RGD PMID:25593290 RGD:38500244 NCBI chrNW_004936550:6,885,484...7,067,001
Ensembl chrNW_004936550:6,886,706...6,945,056 		JBrowse link
G Cdk15 cyclin dependent kinase 15 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,037,614...1,129,961
Ensembl chrNW_004936726:1,037,636...1,130,571 		JBrowse link
G Cflar CASP8 and FADD like apoptosis regulator ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:381,888...425,565
Ensembl chrNW_004936726:381,835...423,311 		JBrowse link
G Clk1 CDC like kinase 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:170,763...178,897
Ensembl chrNW_004936726:170,458...179,545 		JBrowse link
G Cp ceruloplasmin ISO associated with systemic scleroderma;protein:increased expression:serum RGD PMID:32630589 RGD:401827129 NCBI chrNW_004936519:6,431,156...6,473,183
Ensembl chrNW_004936519:6,431,144...6,481,858 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment ISO RGD PMID:33760143 RGD:401960860 NCBI chrNW_004936631:3,721,307...3,785,346
Ensembl chrNW_004936631:3,721,313...3,780,892 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936631:484,356...489,643
Ensembl chrNW_004936631:484,356...489,643 		JBrowse link
G Ctnnd1 catenin delta 1 ISO protein:decreased expression:lung RGD PMID:25593290 RGD:38500244 NCBI chrNW_004936581:4,750,845...4,802,262
Ensembl chrNW_004936581:4,750,947...4,802,289 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 exacerbates ISO compared to wild type RGD PMID:31402164 RGD:151347602 NCBI chrNW_004936608:262,653...397,753
Ensembl chrNW_004936608:262,445...397,762 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 PMID:28492532 PMID:32581362 NCBI chrNW_004936471:3,423,792...3,527,089
Ensembl chrNW_004936471:3,423,813...3,526,913 		JBrowse link
G Eng endoglin ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease ClinVar PMID:10625079 PMID:15517393 PMID:15521985 PMID:15879500 PMID:16705692 More... NCBI chrNW_004936487:15,467,165...15,499,180
Ensembl chrNW_004936487:15,467,835...15,477,488 		JBrowse link
G Fam117b family with sequence similarity 117 member B ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,753,318...1,846,977
Ensembl chrNW_004936726:1,753,652...1,843,405 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase ISO RGD PMID:30107138 RGD:329349307 NCBI chrNW_004936473:397,140...1,424,805
Ensembl chrNW_004936473:676,237...1,424,506 		JBrowse link
G Flacc1 flagellum associated containing coiled-coil domains 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:600,213...631,513
Ensembl chrNW_004936726:600,420...625,853 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase ISO protein:decreased expression:lung RGD PMID:34310344 RGD:329845886 NCBI chrNW_004936475:6,321,725...6,689,410
Ensembl chrNW_004936475:6,321,711...6,689,588 		JBrowse link
G Fzd7 frizzled class receptor 7 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,256,684...1,275,324
Ensembl chrNW_004936726:1,256,678...1,275,467 		JBrowse link
G Gdf2 growth differentiation factor 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 PMID:26801773 PMID:28492532 PMID:31661308 PMID:31727138 NCBI chrNW_004936554:7,307,461...7,322,048
Ensembl chrNW_004936554:7,316,435...7,322,060 		JBrowse link
G Gjb2 gap junction protein beta 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:17666888 PMID:25741868 PMID:30755392 NCBI chrNW_004936720:1,528,205...1,530,296
Ensembl chrNW_004936720:1,528,249...1,528,929 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO associated with systemic scleroderma;protein:decreased expression:serum RGD PMID:32630589 RGD:401827129 NCBI chrNW_004936647:3,904,787...3,914,223
Ensembl chrNW_004936647:3,906,113...3,913,498 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO protein:increased expression:endothelium, smooth muscle, pulmonary artery RGD PMID:28473438 RGD:329955562 NCBI chrNW_004936890:154,252...157,044
Ensembl chrNW_004936890:155,233...156,408 		JBrowse link
G Hycc2 hyccin PI4KA lipid kinase complex subunit 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:261,530...338,105
Ensembl chrNW_004936726:268,873...338,048 		JBrowse link
G Hydin HYDIN axonemal central pair apparatus protein ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 NCBI chrNW_004936475:22,523,962...22,836,355 JBrowse link
G Ica1l islet cell autoantigen 1 like ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,853,178...1,922,684
Ensembl chrNW_004936726:1,853,868...1,902,788 		JBrowse link
G Icos inducible T cell costimulator ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936631:562,650...572,263
Ensembl chrNW_004936631:551,394...570,804 		JBrowse link
G Ifng interferon gamma treatment ISO RGD PMID:23867624 RGD:329848996 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Igf1r insulin like growth factor 1 receptor treatment ISO RGD PMID:30240970 RGD:156430315 NCBI chrNW_004936483:4,563,995...4,860,231
Ensembl chrNW_004936483:4,564,512...4,852,925 		JBrowse link
G Il2 interleukin 2 treatment ISO RGD PMID:23867624 RGD:329848996 NCBI chrNW_004936662:1,594,953...1,599,625
Ensembl chrNW_004936662:1,594,953...1,599,625 		JBrowse link
G Impa1 inositol monophosphatase 1 ISO RGD PMID:30604625 RGD:126781711 NCBI chrNW_004936656:2,598,454...2,616,643
Ensembl chrNW_004936656:2,598,413...2,618,396 		JBrowse link
G Itga5 integrin subunit alpha 5 ISO mRNA:increased expression:lung RGD PMID:25593290 RGD:38500244 NCBI chrNW_004936512:11,588,818...11,612,580
Ensembl chrNW_004936512:11,588,645...11,612,669 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936493:5,767,779...5,772,043
Ensembl chrNW_004936493:5,770,103...5,772,326 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ameliorates ISO RGD PMID:28679649 RGD:329955564 NCBI chrNW_004936706:940,585...952,484 JBrowse link
G Kctd18 potassium channel tetramerization domain containing 18 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936825:396,359...415,478
Ensembl chrNW_004936825:398,875...413,993 		JBrowse link
G LOC101964504 cytochrome P450 20A1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:2,234,611...2,295,527
Ensembl chrNW_004936726:2,235,361...2,298,775 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 treatment ISO RGD PMID:35582418 RGD:155804297 NCBI chrNW_004936510:1,772,971...1,836,075
Ensembl chrNW_004936510:1,772,971...1,837,765 		JBrowse link
G Mpp4 MAGUK p55 scaffold protein 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:893,411...938,876
Ensembl chrNW_004936726:892,550...938,969 		JBrowse link
G Nbeal1 neurobeachin like 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:2,045,202...2,224,477
Ensembl chrNW_004936726:2,045,191...2,224,251 		JBrowse link
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:338,384...349,943
Ensembl chrNW_004936726:338,423...349,943 		JBrowse link
G Nif3l1 NGG1 interacting factor 3 like 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:194,873...212,487
Ensembl chrNW_004936726:195,010...232,429 		JBrowse link
G Nnmt nicotinamide N-methyltransferase ISO protein:increased activity,altered activity:lung, liver (rat) RGD PMID:27581040 RGD:401793717 NCBI chrNW_004936612:333,421...351,202
Ensembl chrNW_004936612:333,421...351,202 		JBrowse link
G Nop58 NOP58 ribonucleoprotein ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,457,038...1,487,374
Ensembl chrNW_004936726:1,457,002...1,486,530 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO RGD PMID:23867624 RGD:329848996 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534 		JBrowse link
G Notch1 notch receptor 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:15472075 PMID:16614245 PMID:18593716 PMID:19245433 PMID:19635999 More... NCBI chrNW_004936669:1,292,016...1,334,061
Ensembl chrNW_004936669:1,292,088...1,332,428 		JBrowse link
G Notch3 notch receptor 3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:22006983 PMID:22153900 PMID:22159056 PMID:24086431 PMID:25741868 More... NCBI chrNW_004936596:5,265,984...5,301,430
Ensembl chrNW_004936596:5,265,999...5,300,429 		JBrowse link
G Orc2 origin recognition complex subunit 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:215,483...259,867
Ensembl chrNW_004936726:211,859...255,754 		JBrowse link
G Park7 Parkinsonism associated deglycase exacerbates ISO RGD PMID:29069575 RGD:151347449 NCBI chrNW_004936623:2,422,780...2,436,817
Ensembl chrNW_004936623:2,422,833...2,436,817 		JBrowse link
G Pdcd4 programmed cell death 4 treatment ISO RGD PMID:30240970 RGD:156430315 NCBI chrNW_004936486:1,684,167...1,705,387
Ensembl chrNW_004936486:1,684,135...1,705,715 		JBrowse link
G Phf6 PHD finger protein 6 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 NCBI chrNW_004936691:716,723...767,960
Ensembl chrNW_004936691:716,697...768,016 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:6144131 PMID:16144131 PMID:16283678 PMID:18602922 PMID:19283792 More... NCBI chrNW_004936750:439,396...468,747 JBrowse link
G Ppil3 peptidylprolyl isomerase like 3 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:181,128...194,823
Ensembl chrNW_004936726:181,140...194,821 		JBrowse link
G Ptgis prostaglandin I2 synthase treatment
susceptibility		 ISO human gene in a rat model
DNA:repeat, SNPs:promoter, intron: , 185C>T, 325C>A ( , rs5582, rs116939356) (human)		 RGD PMID:11034952 PMID:17635855 PMID:18612919 PMID:23841984 PMID:24605778 RGD:401901195 RGD:401901264 RGD:401959335 RGD:401959406 RGD:401959742 NCBI chrNW_004936514:4,775,884...4,814,574
Ensembl chrNW_004936514:4,791,031...4,812,027 		JBrowse link
G Ptprd protein tyrosine phosphatase receptor type D ISO mRNA:decreased expression:blood, pulmonary artery (human) RGD PMID:35848503 RGD:401976433 NCBI chrNW_004936539:2,564,815...3,369,975
Ensembl chrNW_004936539:2,564,793...2,945,293 		JBrowse link
G Raph1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936631:100,072...196,557
Ensembl chrNW_004936631:108,310...196,563 		JBrowse link
G Selenop selenoprotein P ISO associated with systemic scleroderma;protein:decreased expression:serum RGD PMID:32630589 RGD:401827129 NCBI chrNW_004936518:155,905...166,932 JBrowse link
G Sgo2 shugoshin 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936825:350,390...373,005
Ensembl chrNW_004936825:341,283...373,012 		JBrowse link
G Smad4 SMAD family member 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25559809 PMID:25741868 PMID:26467025 PMID:28492532 PMID:29684080 NCBI chrNW_004936497:12,242,869...12,278,012
Ensembl chrNW_004936497:12,249,140...12,278,123 		JBrowse link
G Smad9 SMAD family member 9 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease ClinVar PMID:25741868 PMID:28492532 PMID:30029678 NCBI chrNW_004936472:30,980,850...31,050,138
Ensembl chrNW_004936472:30,980,928...31,049,618 		JBrowse link
G Sod2 superoxide dismutase 2 ISO protein:decreased expression:pulmonary artery
protein:decreased expression:small pulmonary artery		 RGD PMID:20529999 RGD:27095884 NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781 		JBrowse link
G Sox17 SRY-box transcription factor 17 susceptibility
onset		 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension
DNA:SNPs:enhancers: (rs10103692, rs13266183) (human)
DNA:frameshift mutations, missense mutations, SNP:CDS, intron:multiple (human)		 ClinVar
RGD		 PMID:29650961 PMID:30527955 RGD:329853735 RGD:329955464 NCBI chrNW_004936496:1,248,582...1,251,406
Ensembl chrNW_004936496:1,248,577...1,251,430 		JBrowse link
G Spats2l spermatogenesis associated serine rich 2 like ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936825:423,986...591,062
Ensembl chrNW_004936825:423,984...591,495 		JBrowse link
G Stradb STE20 related adaptor beta ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:709,037...728,696
Ensembl chrNW_004936726:709,038...731,338 		JBrowse link
G Sumo1 small ubiquitin like modifier 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,402,977...1,413,974
Ensembl chrNW_004936726:1,399,050...1,429,205 		JBrowse link
G Tbx4 T-box transcription factor 4 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension | ClinVar Annotator: match by term: Pulmonary arterial hypertension associated with congenital heart disease ClinVar PMID:15106123 PMID:16199547 PMID:23592887 PMID:25741868 PMID:28492532 More... NCBI chrNW_004936490:2,823,531...2,853,282
Ensembl chrNW_004936490:2,827,416...2,852,917 		JBrowse link
G Tgfbr1 transforming growth factor beta receptor 1 ISO mRNA:increased expression:lung RGD PMID:25593290 RGD:38500244 NCBI chrNW_004936524:7,656,523...7,680,043
Ensembl chrNW_004936524:7,655,847...7,681,097 		JBrowse link
G Tmem237 transmembrane protein 237 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:872,368...892,185
Ensembl chrNW_004936726:869,238...891,283 		JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:25741868 NCBI chrNW_004936529:6,788,713...6,841,824
Ensembl chrNW_004936529:6,788,187...6,841,888 		JBrowse link
G Trak2 trafficking kinesin protein 2 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:649,413...708,816
Ensembl chrNW_004936726:649,418...708,820 		JBrowse link
G Trpc4 transient receptor potential cation channel subfamily C member 4 ameliorates ISO RGD PMID:24113457 RGD:150429956 NCBI chrNW_004936472:31,710,873...31,909,106
Ensembl chrNW_004936472:31,711,040...31,843,876 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO mRNA, protein:increased expression: pulmonary artery,lung: RGD PMID:25593290 RGD:38500244 NCBI chrNW_004936546:5,331,220...5,332,669
Ensembl chrNW_004936546:5,331,863...5,332,555 		JBrowse link
G Vim vimentin ISO protein:increased phosphorylation:lung RGD PMID:25593290 RGD:38500244 NCBI chrNW_004936520:10,051,692...10,059,324
Ensembl chrNW_004936520:10,052,012...10,059,182 		JBrowse link
G Wdr12 WD repeat domain 12 ISO ClinVar Annotator: match by term: Pulmonary arterial hypertension ClinVar PMID:32581362 NCBI chrNW_004936726:1,931,221...1,958,457
Ensembl chrNW_004936726:1,931,183...1,958,215 		JBrowse link
Pulmonary Arterial Hypertension, Hereditary Hemorrhagic Telangiectasia-Related term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 ISO ClinVar Annotator: match by term: PULMONARY ARTERIAL HYPERTENSION, HEREDITARY HEMORRHAGIC TELANGIECTASIA-RELATED ClinVar PMID:8640225 PMID:9245985 PMID:10187774 PMID:10767348 PMID:11170071 More... NCBI chrNW_004936512:9,364,551...9,379,131
Ensembl chrNW_004936512:9,364,149...9,379,431 		JBrowse link
G Eng endoglin ISO ClinVar Annotator: match by term: PULMONARY ARTERIAL HYPERTENSION, HEREDITARY HEMORRHAGIC TELANGIECTASIA-RELATED ClinVar PMID:14684682 PMID:15024723 PMID:15115879 PMID:15687131 PMID:15879500 More... NCBI chrNW_004936487:15,467,165...15,499,180
Ensembl chrNW_004936487:15,467,835...15,477,488 		JBrowse link
Pulmonary Edema of Mountaineers term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnm1l dynamin 1 like ISO mRNA:increased expression:lung (rat) RGD PMID:23517027 RGD:12738217 NCBI chrNW_004936607:3,576,357...3,632,423
Ensembl chrNW_004936607:3,576,392...3,632,554 		JBrowse link
G Fis1 fission, mitochondrial 1 ISO mRNA:increased expression:lung (rat) RGD PMID:23517027 RGD:12738217 NCBI chrNW_004936543:1,112,746...1,116,521
Ensembl chrNW_004936543:1,112,742...1,116,518 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25373139 NCBI chrNW_004936576:2,353,874...2,411,747
Ensembl chrNW_004936576:2,353,761...2,411,425 		JBrowse link
G Hmox1 heme oxygenase 1 ISO protein:increased expression:lung RGD PMID:21296072 RGD:10755745 NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311 		JBrowse link
G Mfn2 mitofusin 2 ISO mRNA:decreased expression:lung (rat) RGD PMID:23517027 RGD:12738217 NCBI chrNW_004936474:767,754...795,258
Ensembl chrNW_004936474:767,671...796,556 		JBrowse link
Pulmonary Hypertension, Chronic Thromboembolic, without Deep Vein Thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101963197 HLA class II histocompatibility antigen, DP beta 1 chain susceptibility ISO DNA:polymorphisms:cds:HLA-DPB1*0202 (human) RGD PMID:19165231 RGD:5143999 NCBI chrNW_004936476:25,730,800...25,741,089
Ensembl chrNW_004936476:25,730,596...25,741,145 		JBrowse link
Pulmonary Hypertension, Hypoxia-Induced term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor treatment ISO RGD PMID:33836606 RGD:401940192 NCBI chrNW_004936546:3,737,908...3,783,492
Ensembl chrNW_004936546:3,737,851...3,783,588 		JBrowse link
G Egfr epidermal growth factor receptor treatment ISO RGD PMID:31264901 RGD:38599217 NCBI chrNW_004936678:365,005...560,546
Ensembl chrNW_004936678:365,834...436,528 		JBrowse link
G Egln1 egl-9 family hypoxia inducible factor 1 ISO RGD PMID:16761101 RGD:11252085 NCBI chrNW_004936484:19,343,770...19,386,087 JBrowse link
G Egln3 egl-9 family hypoxia inducible factor 3 ISO RGD PMID:16761101 RGD:11252085 NCBI chrNW_004936494:8,240,272...8,267,487
Ensembl chrNW_004936494:8,238,858...8,267,606 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment ISO RGD PMID:25063801 RGD:10449119 NCBI chrNW_004936809:1,269,900...1,285,853
Ensembl chrNW_004936809:1,269,914...1,285,889 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 ISO mRNA:decreased expression:lung (rat) RGD PMID:19823174 RGD:4145499 NCBI chrNW_004936636:617,376...640,424
Ensembl chrNW_004936636:617,356...640,932 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase ISO mRNA, protein:increased expression:lung RGD PMID:24657469 RGD:11667099 NCBI chrNW_004936516:5,551,192...5,578,796
Ensembl chrNW_004936516:5,550,203...5,578,832 		JBrowse link
G LOC101969148 cytochrome P450 1A1 ISO mRNA:increased expression:lung (rat) RGD PMID:33836606 RGD:401940192 NCBI chrNW_004936471:33,682,730...33,688,332
Ensembl chrNW_004936471:33,682,730...33,688,332 		JBrowse link
G Mfn2 mitofusin 2 ISO mRNA, protein:decreased expression:lung (rat) RGD PMID:26485208 RGD:12910856 NCBI chrNW_004936474:767,754...795,258
Ensembl chrNW_004936474:767,671...796,556 		JBrowse link
G Nog noggin ISO mRNA,protein:decreased expression:lung: RGD PMID:25740156 RGD:12801489 NCBI chrNW_004936490:6,262,651...6,264,069
Ensembl chrNW_004936490:6,262,785...6,263,483 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO mRNA,protein:increased expression:pulmonary artery RGD PMID:9950873 RGD:11533933 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534 		JBrowse link
G Pcna proliferating cell nuclear antigen ISO protein:increased expression:lung (rat) RGD PMID:26485208 RGD:12910856 NCBI chrNW_004936485:13,766,221...13,771,215 JBrowse link
G Ptgis prostaglandin I2 synthase treatment ISO RGD PMID:12062720 RGD:401959327 NCBI chrNW_004936514:4,775,884...4,814,574
Ensembl chrNW_004936514:4,791,031...4,812,027 		JBrowse link
G Ptprd protein tyrosine phosphatase receptor type D ISO mRNA, protein:decreased expression:pulmonary artery (rat) RGD PMID:35848503 RGD:401976433 NCBI chrNW_004936539:2,564,815...3,369,975
Ensembl chrNW_004936539:2,564,793...2,945,293 		JBrowse link
G Slc39a12 solute carrier family 39 member 12 severity ISO RGD PMID:26258299 RGD:10401832 NCBI chrNW_004936520:9,380,723...9,444,146
Ensembl chrNW_004936520:9,380,650...9,444,152 		JBrowse link
G Sox17 SRY-box transcription factor 17 exacerbates ISO protein:decreased expression:pulmonary artery endothelium (mouse) RGD PMID:36205124 PMID:36913491 PMID:36919784 PMID:37066790 RGD:329853316 RGD:329853317 RGD:329853734 RGD:329853737 NCBI chrNW_004936496:1,248,582...1,251,406
Ensembl chrNW_004936496:1,248,577...1,251,430 		JBrowse link
pulmonary venoocclusive disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 ISO protein:increased expression:lung RGD PMID:32209028 RGD:38549370 NCBI chrNW_004936492:2,114,478...2,115,969
Ensembl chrNW_004936492:2,110,634...2,115,996 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chrNW_004936726:1,543,263...1,711,422
Ensembl chrNW_004936726:1,543,245...1,704,541 		JBrowse link
G Ddit3 DNA damage inducible transcript 3 ISO protein:increased expression:lung, endothelial cell RGD PMID:32209028 RGD:38549370 NCBI chrNW_004936646:1,665,019...1,669,212 JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2 alpha kinase 2 ISO protein:increased expression:lung RGD PMID:32209028 RGD:38549370 NCBI chrNW_004936663:1,127,047...1,157,263
Ensembl chrNW_004936663:1,126,977...1,157,137 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO protein:increased expression:lung RGD PMID:32209028 RGD:38549370 NCBI chrNW_004936712:413,602...454,443
Ensembl chrNW_004936712:414,446...454,449 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 disease_progression ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:lung		 CTD
RGD		 PMID:24292273 PMID:32209028 RGD:38549370 NCBI chrNW_004936471:3,423,792...3,527,089
Ensembl chrNW_004936471:3,423,813...3,526,913 		JBrowse link
G Erg ETS transcription factor ERG ISO protein:decreased expression:lung RGD PMID:32209028 RGD:38549370 NCBI chrNW_004936500:4,459,298...4,623,290
Ensembl chrNW_004936500:4,459,275...4,624,432 		JBrowse link
G Hmox1 heme oxygenase 1 ISO protein:increased expression:lung
protein:increased expression:lung, endothelial cell		 RGD PMID:32209028 RGD:38549370 NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 ISO RGD PMID:32209028 RGD:38549370 NCBI chrNW_004936493:5,767,779...5,772,043
Ensembl chrNW_004936493:5,770,103...5,772,326 		JBrowse link
pulmonary venoocclusive disease 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr2 bone morphogenetic protein receptor type 2 ISO ClinVar Annotator: match by term: BMPR2-related condition | ClinVar Annotator: match by term: Pulmonary venoocclusive disease 1 OMIM
ClinVar		 PMID:3291115 PMID:10903931 PMID:11115378 PMID:11502704 PMID:12045205 More... NCBI chrNW_004936726:1,543,263...1,711,422
Ensembl chrNW_004936726:1,543,245...1,704,541 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO ClinVar Annotator: match by term: Pulmonary venoocclusive disease 1 ClinVar PMID:24033266 NCBI chrNW_004936471:3,423,792...3,527,089
Ensembl chrNW_004936471:3,423,813...3,526,913 		JBrowse link
pulmonary venoocclusive disease 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr2 bone morphogenetic protein receptor type 2 ISO ClinVar Annotator: match by term: Familial pulmonary capillary hemangiomatosis ClinVar PMID:18626305 PMID:24292273 NCBI chrNW_004936726:1,543,263...1,711,422
Ensembl chrNW_004936726:1,543,245...1,704,541 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO ClinVar Annotator: match by term: EIF2AK4-related condition | ClinVar Annotator: match by term: Familial pulmonary capillary hemangiomatosis OMIM
ClinVar		 PMID:12215525 PMID:24033266 PMID:24135949 PMID:24292273 PMID:24310610 More... NCBI chrNW_004936471:3,423,792...3,527,089
Ensembl chrNW_004936471:3,423,813...3,526,913 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14498
    disease of anatomical entity 14147
      respiratory system disease 3171
        lower respiratory tract disease 2032
          lung disease 1995
            pulmonary hypertension 359
              Dursun Syndrome 0
              Familial Cirrhosis with Pulmonary Hypertension 0
              HUPRA Syndrome 2
              Pulmonary Arterial Hypertension + 92
              Pulmonary Edema of Mountaineers 5
              Pulmonary Hypertension, Chronic Thromboembolic, without Deep Vein Thrombosis 1
              Pulmonary Hypertension, Hypoxia-Induced 16
              Rowley-Rosenberg Syndrome 0
              Vater-Like Defects with Pulmonary Hypertension, Laryngeal Webs, and Growth Deficiency 0
              persistent fetal circulation syndrome 38
              primary pulmonary hypertension + 108
              pulmonary venoocclusive disease + 9
Path 2
Term Annotations click to browse term
  disease 14498
    disease of anatomical entity 14147
      cardiovascular system disease 4139
        vascular disease 2903
          artery disease 1926
            hypertension 953
              pulmonary hypertension 359
                Dursun Syndrome 0
                Familial Cirrhosis with Pulmonary Hypertension 0
                HUPRA Syndrome 2
                Pulmonary Arterial Hypertension + 92
                Pulmonary Edema of Mountaineers 5
                Pulmonary Hypertension, Chronic Thromboembolic, without Deep Vein Thrombosis 1
                Pulmonary Hypertension, Hypoxia-Induced 16
                Rowley-Rosenberg Syndrome 0
                Vater-Like Defects with Pulmonary Hypertension, Laryngeal Webs, and Growth Deficiency 0
                persistent fetal circulation syndrome 38
                primary pulmonary hypertension + 108
                pulmonary venoocclusive disease + 9
paths to the root