Prkg1 (protein kinase cGMP-dependent 1) - Rat Genome Database

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Gene: Prkg1 (protein kinase cGMP-dependent 1) Ictidomys tridecemlineatus
Analyze
Symbol: Prkg1
Name: protein kinase cGMP-dependent 1
RGD ID: 12440473
Description: ENCODES a protein that exhibits identical protein binding (ortholog); mitogen-activated protein kinase p38 binding (ortholog); INVOLVED IN cell growth involved in cardiac muscle cell development (ortholog); cerebellum development (ortholog); cGMP-mediated signaling (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ASSOCIATED WITH allergic rhinitis (ortholog); amphetamine abuse (ortholog); connective tissue disease (ortholog); FOUND IN acrosomal vesicle (ortholog); nucleoplasm (ortholog); sarcolemma (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cGMP-dependent protein kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721375,309,475 - 76,469,932 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936787332,342 - 1,491,285 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936787330,390 - 1,491,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Prkg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721375,309,475 - 76,469,932 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936787332,342 - 1,491,285 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936787330,390 - 1,491,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381050,990,888 - 52,298,350 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1050,990,888 - 52,298,423 (+)EnsemblGRCh38hg38GRCh38
GRCh371052,750,648 - 54,058,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361052,420,951 - 53,725,280 (+)NCBINCBI36Build 36hg18NCBI36
Build 341052,504,298 - 53,725,280NCBI
Celera1046,013,603 - 47,318,321 (+)NCBICelera
Cytogenetic Map10q11.23-q21.1NCBI
HuRef1046,729,527 - 48,036,312 (+)NCBIHuRef
CHM1_11053,032,644 - 54,339,928 (+)NCBICHM1_1
T2T-CHM13v2.01051,839,480 - 53,144,930 (+)NCBIT2T-CHM13v2.0
Prkg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,541,887 - 31,742,675 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,541,889 - 31,742,433 (-)EnsemblGRCm39 Ensembl
GRCm381930,564,487 - 31,765,268 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,564,489 - 31,765,033 (-)EnsemblGRCm38mm10GRCm38
MGSCv371930,642,041 - 31,839,523 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,633,548 - 31,831,030 (-)NCBIMGSCv36mm8
Celera1931,351,778 - 32,553,439 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.17NCBI
Prkg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,818,950 - 239,052,184 (-)NCBIGRCr8
mRatBN7.21228,409,605 - 229,638,794 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1228,408,947 - 229,639,080 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,778,127 - 238,005,258 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,707,829 - 244,934,964 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,538,254 - 237,776,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,982,039 - 250,300,952 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01256,221,067 - 257,537,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,420,597 - 235,765,375 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,515,049 - 235,845,833 (-)NCBI
Celera1225,545,145 - 226,760,176 (-)NCBICelera
Cytogenetic Map1q52NCBI
Prkg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554256,176,432 - 7,331,446 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554256,176,335 - 7,335,867 (+)NCBIChiLan1.0ChiLan1.0
PRKG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2863,299,984 - 64,595,221 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11063,306,357 - 64,600,543 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01047,642,312 - 48,935,188 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11049,778,821 - 51,069,314 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1049,779,211 - 51,064,882 (+)Ensemblpanpan1.1panPan2
PRKG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12635,732,974 - 36,932,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2635,737,242 - 36,932,729 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2635,620,229 - 36,818,502 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02637,271,288 - 38,465,630 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2637,275,477 - 38,465,591 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12635,169,158 - 36,367,548 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02634,756,074 - 35,955,695 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02635,996,645 - 37,196,072 (-)NCBIUU_Cfam_GSD_1.0
PRKG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,558,533 - 98,793,010 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,558,531 - 98,793,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214106,256,149 - 107,028,245 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.214107,499,623 - 107,663,552 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1978,858,269 - 80,188,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604839,812,502 - 40,750,048 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479111,338,510 - 12,654,812 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479111,334,146 - 12,656,480 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000007357   ⟹   ENSSTOP00000006573
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936787332,342 - 1,491,285 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000040938   ⟹   ENSSTOP00000024466
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049367871,468,986 - 1,491,285 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000041088   ⟹   ENSSTOP00000029581
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936787332,342 - 1,413,731 (-)Ensembl
RefSeq Acc Id: XM_005340332   ⟹   XP_005340389
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721375,309,475 - 76,392,751 (-)NCBI
SpeTri2.0NW_004936787330,803 - 1,414,768 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021720211   ⟹   XP_021575886
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721375,310,547 - 76,469,932 (-)NCBI
SpeTri2.0NW_004936787330,390 - 1,491,994 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040273013   ⟹   XP_040128947
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721375,309,475 - 75,348,002 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005340389   ⟸   XM_005340332
- Peptide Label: isoform X1
- UniProtKB: A0A287D7T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021575886   ⟸   XM_021720211
- Peptide Label: isoform X2
- UniProtKB: I3M9K0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040128947   ⟸   XM_040273013
- Peptide Label: isoform X3
RefSeq Acc Id: ENSSTOP00000024466   ⟸   ENSSTOT00000040938
RefSeq Acc Id: ENSSTOP00000006573   ⟸   ENSSTOT00000007357
RefSeq Acc Id: ENSSTOP00000029581   ⟸   ENSSTOT00000041088
Protein Domains
AGC-kinase C-terminal   cGMP-dependent protein kinase N-terminal coiled-   Cyclic nucleotide-binding   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000007346 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000007357.3 UniProtKB/TrEMBL
  ENSSTOT00000040938.1 UniProtKB/TrEMBL
  ENSSTOT00000041088.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  cGMP_dep_kinase UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PKcGMP_CC UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  STKc_cGK UniProtKB/TrEMBL
NCBI Gene Prkg1 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE UniProtKB/TrEMBL
  PROTEIN KINASE CGMP-DEPENDENT 1 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  PKcGMP_CC UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PIRSF cGMP-dep_kinase UniProtKB/TrEMBL
PRINTS CGMPKINASE UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  CNMP_BINDING_1 UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
  S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A287CT48_ICTTR UniProtKB/TrEMBL
  A0A287D7T9 ENTREZGENE, UniProtKB/TrEMBL
  I3M9K0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-24 Prkg1  protein kinase cGMP-dependent 1    protein kinase, cGMP-dependent, type I  Symbol and/or name change 5135510 APPROVED