Lepr (leptin receptor) - Rat Genome Database

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Gene: Lepr (leptin receptor) Ictidomys tridecemlineatus
Analyze
Symbol: Lepr
Name: leptin receptor
RGD ID: 12691089
Description: ENCODES a protein that exhibits identical protein binding (ortholog); peptide hormone binding (ortholog); protein-hormone receptor activity (ortholog); INVOLVED IN angiogenesis (ortholog); cellular response to acetate (ortholog); cellular response to butyrate (ortholog); PARTICIPATES IN altered energy homeostasis pathway; altered leptin system pathway; energy homeostasis pathway; ASSOCIATED WITH Albuminuria (ortholog); Animal Disease Models (ortholog); arteriosclerosis (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leptin receptor, transcript variant X1; leptin receptor, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505878,634,973 - 78,718,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365915,774,326 - 5,836,444 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365915,771,371 - 5,846,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Albuminuria  (ISO)
Animal Disease Models  (ISO)
arteriosclerosis  (ISO)
bone disease  (ISO)
Breast Neoplasms  (ISO)
cardiomyopathy  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Delayed Puberty  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
Diastolic Dysfunction  (ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO)
Dyslipidemias  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial hyperlipidemia  (ISO)
Female Infertility  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
Gliosis  (ISO)
glucose intolerance  (ISO)
granulosa cell tumor  (ISO)
hepatocellular carcinoma  (ISO)
hepatocellular clear cell carcinoma  (ISO)
Hepatomegaly  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperphagia  (ISO)
hypertension  (ISO)
hypogonadism  (ISO)
infertility  (ISO)
inherited metabolic disorder  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Knee Osteoarthritis  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leptin Receptor Deficiency  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
morbid obesity  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
nephritis  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
osteoporosis  (ISO)
Overweight  (ISO)
pancreas disease  (ISO)
pancreatitis  (ISO)
pituitary gland disease  (ISO)
Pneumococcal Pneumonia  (ISO)
pre-eclampsia  (ISO)
Precocious Puberty  (ISO)
primary biliary cholangitis  (ISO)
primary immunodeficiency disease  (ISO)
primary ovarian insufficiency  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal fibrosis  (ISO)
Respiratory Tract Infections  (ISO)
Right Ventricular Hypertrophy  (ISO)
short bowel syndrome  (ISO)
sleep apnea  (ISO)
Spinal Fractures  (ISO)
steatotic liver disease  (ISO)
type 2 diabetes mellitus  (ISO)
Varicose Ulcer  (ISO)
Ventricular Dysfunction, Left  (ISO)
Weight Gain  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:25640202   PMID:30032202  


Genomics

Comparative Map Data
Lepr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505878,634,973 - 78,718,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365915,774,326 - 5,836,444 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365915,771,371 - 5,846,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38165,420,652 - 65,641,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl165,420,652 - 65,641,559 (+)EnsemblGRCh38hg38GRCh38
GRCh37165,886,335 - 66,107,242 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,658,906 - 65,875,410 (+)NCBINCBI36Build 36hg18NCBI36
Build 34165,598,338 - 65,814,843NCBI
Celera164,176,916 - 64,393,787 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef163,995,123 - 64,212,195 (+)NCBIHuRef
CHM1_1166,002,606 - 66,219,234 (+)NCBICHM1_1
T2T-CHM13v2.0165,298,629 - 65,519,352 (+)NCBIT2T-CHM13v2.0
Lepr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394101,574,393 - 101,676,375 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4101,574,601 - 101,672,549 (+)EnsemblGRCm39 Ensembl
GRCm384101,717,137 - 101,815,352 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4101,717,404 - 101,815,352 (+)EnsemblGRCm38mm10GRCm38
MGSCv374101,390,012 - 101,487,959 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364101,215,371 - 101,313,237 (+)NCBIMGSCv36mm8
Celera4100,061,452 - 100,155,523 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.96NCBI
Lepr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85121,409,735 - 121,593,201 (+)NCBIGRCr8
mRatBN7.25116,294,409 - 116,477,904 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5116,289,823 - 116,475,908 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5118,847,763 - 119,019,098 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05120,573,106 - 120,744,441 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05120,624,429 - 120,795,760 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05120,503,475 - 120,682,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5120,564,645 - 120,682,221 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05124,380,327 - 124,525,200 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05124,555,678 - 124,556,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45122,320,075 - 122,503,449NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5114,817,255 - 114,982,861 (+)NCBICelera
RH 3.4 Map5 RGD
Cytogenetic Map5q33NCBI
Lepr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542325,111,266 - 25,185,407 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542325,108,897 - 25,185,315 (-)NCBIChiLan1.0ChiLan1.0
LEPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21161,226,191 - 161,441,177 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11160,386,446 - 160,592,001 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0164,772,612 - 64,881,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1166,651,994 - 66,764,768 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl166,693,926 - 66,764,768 (+)Ensemblpanpan1.1panPan2
LEPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1544,684,118 - 44,775,626 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl544,688,109 - 44,775,636 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha544,745,719 - 44,810,649 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0544,870,825 - 44,963,640 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl544,875,468 - 44,963,183 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1544,840,852 - 44,906,048 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0544,786,008 - 44,851,055 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0545,029,763 - 45,094,688 (-)NCBIUU_Cfam_GSD_1.0
LEPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6146,801,954 - 146,895,995 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16146,802,297 - 146,896,152 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LEPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12067,454,205 - 67,567,524 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2067,454,334 - 67,524,229 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603349,988,602 - 50,125,048 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lepr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474229,223,392 - 29,337,049 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474229,221,742 - 29,313,273 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000028423   ⟹   ENSSTOP00000019709
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365915,774,326 - 5,836,396 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000031248   ⟹   ENSSTOP00000031297
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365915,778,784 - 5,836,444 (-)Ensembl
RefSeq Acc Id: XM_040288789   ⟹   XP_040144723
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505878,634,975 - 78,718,201 (+)NCBI
RefSeq Acc Id: XM_040288790   ⟹   XP_040144724
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505878,634,975 - 78,718,201 (+)NCBI
RefSeq Acc Id: XM_040288791   ⟹   XP_040144725
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505878,634,973 - 78,718,201 (+)NCBI
RefSeq Acc Id: XM_040288792   ⟹   XP_040144726
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505878,673,470 - 78,718,201 (+)NCBI
RefSeq Acc Id: XM_040288793   ⟹   XP_040144727
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505878,634,980 - 78,714,302 (+)NCBI
RefSeq Acc Id: XM_040288794   ⟹   XP_040144728
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505878,634,980 - 78,712,063 (+)NCBI
RefSeq Acc Id: XM_040288795   ⟹   XP_040144729
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505878,634,982 - 78,712,063 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_040144725   ⟸   XM_040288791
- Peptide Label: isoform X2
- UniProtKB: I3N5R3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040144723   ⟸   XM_040288789
- Peptide Label: isoform X1
- UniProtKB: I3N5R3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040144724   ⟸   XM_040288790
- Peptide Label: isoform X1
- UniProtKB: I3N5R3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040144727   ⟸   XM_040288793
- Peptide Label: isoform X4
- UniProtKB: A0A287DCJ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040144728   ⟸   XM_040288794
- Peptide Label: isoform X5
- UniProtKB: A0A287DCJ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040144729   ⟸   XM_040288795
- Peptide Label: isoform X6
- UniProtKB: A0A287DCJ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040144726   ⟸   XM_040288792
- Peptide Label: isoform X3
- UniProtKB: I3N5R3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000019709   ⟸   ENSSTOT00000028423
RefSeq Acc Id: ENSSTOP00000031297   ⟸   ENSSTOT00000031248
Protein Domains
Fibronectin type-III   Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000022005 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000028423.2 UniProtKB/TrEMBL
  ENSSTOT00000031248.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Hematopoietin_rcpt_Gp130_CS UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  IgC2-like_lig-bd UniProtKB/TrEMBL
  LEP-R_IGD UniProtKB/TrEMBL
NCBI Gene Lepr ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  MYOTACTIN FORM B UniProtKB/TrEMBL
Pfam Lep_receptor_Ig UniProtKB/TrEMBL
  ObR_Ig UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  HEMATOPO_REC_L_F2 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
UniProt A0A287DCJ9 ENTREZGENE, UniProtKB/TrEMBL
  I3N5R3 ENTREZGENE, UniProtKB/TrEMBL