RGD Reference Report - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition - Rat Genome Database

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Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

Authors: Chen, X  Cheng, D  Guan, J  Xia, X  Fan, L  Su, Q 
Citation: Chen X, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Jul;34(3):555-8.
RGD ID: 4848274
Pubmed: PMID:12910720   (View Abstract at PubMed)

OBJECTIVE: To evaluate the role of cysteinyl leukotriene(CysLT) in the pathogenesis of hypoxic pulmonary hypertension and the preventive effects of montelukast, a CysLT receptor antagonist, on hypoxic pulmonary hypertension. METHODS: Thirty male Wistar rats were randomly divided into three groups: control group, hypoxic group and montelukast preventive group. The animal model of pulmonary hypertension was established by exposing the rats to normabaric hypoxic conditions for 3 weeks. The thickness of pulmonary arterioles was measured by a computerized image analyzer. The level of LTC4 in plasma was measured by EIA. RESULTS: In the hypoxic group, the index of right ventricular hypertrophy[RV/(LV + S)] and the index of wall thickness of pulmonary arteriole (WT% and WA%) increased significantly when compared against those in the control group [RV/(LV + S): 30.85% +/- 1.44% vs 20.75% +/- 1.97%; WT%: 23.54% +/- 4.43% vs 13.17% +/- 3.67%; WA%: 72.76% +/- 9.28% vs 50.41% +/- 6.37%, P < 0.01, respectively]. Meanwhile, the plasma level of LTC4 in hypoxic rats was higher than that in control rats [(2395.40 +/- 193.86) pg/ml vs (1006.50 +/- 193.17) pg/ml, P < 0.01]. In the preventive group, the RV/(LV + S) (24.09% +/- 1.09%), WT% (15.44% +/- 4.72%) and WA% (51.98% +/- 12.18%) decreased remarkably as compared with those of the hypoxic group(P < 0.01). The plasma level of LTC4 in the preventive group (2706.25 +/- 350.49 pg/ml) was not significantly different from that in the hypoxic group(P > 0.05). CONCLUSION: Chronic hypoxia stimulates synthesis and release of LTC4. CysLT may play an important role in the pathogenesis of hypoxic pulmonary hypertension and montelukast can prevent hypoxi pulmonary hypertension.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CYSLTR1Humanpulmonary hypertension  ISOCysltr1 (Rattus norvegicus)associated with AnoxiaRGD 
Cysltr1Ratpulmonary hypertension  IMP associated with AnoxiaRGD 
Cysltr1Mousepulmonary hypertension  ISOCysltr1 (Rattus norvegicus)associated with AnoxiaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cysltr1  (cysteinyl leukotriene receptor 1)

Genes (Mus musculus)
Cysltr1  (cysteinyl leukotriene receptor 1)

Genes (Homo sapiens)
CYSLTR1  (cysteinyl leukotriene receptor 1)


Additional Information